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Open AccessArticle

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
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Author to whom correspondence should be addressed.
Molecules 2017, 22(2), 268; https://doi.org/10.3390/molecules22020268
Received: 13 December 2016 / Accepted: 7 February 2017 / Published: 10 February 2017
(This article belongs to the Section Organic Chemistry)
In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with hydrazonoyl halides. Also, hydrazonoyl halides were reacted with thiosemicarbazone and pyrazolylthioamide to give 1,3-thiazoles derivatives. Subsequently, 3-phenyl2-en-1-one was used to synthesize substituted pyridines and substituted nicotinic acid ester. The latter was converted to its azide compound which was reacted with aromatic amines and phenol to give substituted urea and phenylcarbamate containing 1,2,3-triazole moiety. The newly synthesized compounds were established by elemental analysis, spectral data and alternative synthesis whenever possible. View Full-Text
Keywords: 1,3,4-thiadiazoles; 1,2,3-triazoles; hydrazonoyl halides; pyridines; nicotinic ester 1,3,4-thiadiazoles; 1,2,3-triazoles; hydrazonoyl halides; pyridines; nicotinic ester
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MDPI and ACS Style

Abdelriheem, N.A.; Mohamed, A.M.M.; Abdelhamid, A.O. Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety. Molecules 2017, 22, 268.

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