Next Article in Journal
Evaluation of the Effect of Two Volatile Organic Compounds on Barley Pathogens
Previous Article in Journal
Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(9), 1126;

Aspirination of α-Aminoalcohol (Sarpogrelate M1)

Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 August 2016 / Revised: 23 August 2016 / Accepted: 24 August 2016 / Published: 25 August 2016
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [1128 KB, uploaded 25 August 2016]   |  


Aspirination of α-aminoalcohol (sarpogrelate M1) has been performed under various general esterification conditions. In most cases, the desired aspirinate ester was obtained at a low yield with unexpected byproducts, the formation of which was mostly derived from the chemical properties of the tertiary α-amino group. After systematic analysis of those methods, the aspirinated sarpogrelate M1 was prepared using a two-step approach combining salicylate ester formation and acetylation. View Full-Text
Keywords: aspirin; sarpogrelate; α-aminoalcohol; esterification aspirin; sarpogrelate; α-aminoalcohol; esterification

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Park, S.; Lee, J.; Shin, K.J.; Seo, J.H. Aspirination of α-Aminoalcohol (Sarpogrelate M1). Molecules 2016, 21, 1126.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top