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Microfluidic Devices in Advanced Caenorhabditis elegans Research

Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600 036, India
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(8), 1006;
Received: 31 May 2016 / Revised: 19 July 2016 / Accepted: 27 July 2016 / Published: 2 August 2016
(This article belongs to the Special Issue Micro/Nano Fluidics and Bio-MEMS)
The study of model organisms is very important in view of their potential for application to human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis elegans. As a nematode, C. elegans have ~65% similarity with human disease genes and, therefore, studies on C. elegans can be translated to human, as well as, C. elegans can be used in the study of different types of parasitic worms that infect other living organisms. In the past decade, many efforts have been undertaken to establish interdisciplinary research collaborations between biologists, physicists and engineers in order to develop microfluidic devices to study the biology of C. elegans. Microfluidic devices with the power to manipulate and detect bio-samples, regents or biomolecules in micro-scale environments can well fulfill the requirement to handle worms under proper laboratory conditions, thereby significantly increasing research productivity and knowledge. The recent development of different kinds of microfluidic devices with ultra-high throughput platforms has enabled researchers to carry out worm population studies. Microfluidic devices primarily comprises of chambers, channels and valves, wherein worms can be cultured, immobilized, imaged, etc. Microfluidic devices have been adapted to study various worm behaviors, including that deepen our understanding of neuromuscular connectivity and functions. This review will provide a clear account of the vital involvement of microfluidic devices in worm biology. View Full-Text
Keywords: worm chips; microfluidics devices; C. elegans; worm immobilization; model organism; nematode worm worm chips; microfluidics devices; C. elegans; worm immobilization; model organism; nematode worm
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MDPI and ACS Style

Muthaiyan Shanmugam, M.; Subhra Santra, T. Microfluidic Devices in Advanced Caenorhabditis elegans Research. Molecules 2016, 21, 1006.

AMA Style

Muthaiyan Shanmugam M, Subhra Santra T. Microfluidic Devices in Advanced Caenorhabditis elegans Research. Molecules. 2016; 21(8):1006.

Chicago/Turabian Style

Muthaiyan Shanmugam, Muniesh, and Tuhin Subhra Santra. 2016. "Microfluidic Devices in Advanced Caenorhabditis elegans Research" Molecules 21, no. 8: 1006.

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