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Open AccessArticle

Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

1
Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt
2
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia
3
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
4
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(1), 12; https://doi.org/10.3390/molecules21010012
Received: 9 November 2015 / Revised: 30 November 2015 / Accepted: 1 December 2015 / Published: 22 December 2015
(This article belongs to the Section Organic Chemistry)
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively. View Full-Text
Keywords: benzimidazole-thione; thiazino[3,2-a]benzimidazole; X-ray benzimidazole-thione; thiazino[3,2-a]benzimidazole; X-ray
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MDPI and ACS Style

El Ashry, E.S.H.; El Kilany, Y.; Nahas, N.M.; Barakat, A.; Al-Qurashi, N.; Ghabbour, H.A.; Fun, H.-K. Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions. Molecules 2016, 21, 12. https://doi.org/10.3390/molecules21010012

AMA Style

El Ashry ESH, El Kilany Y, Nahas NM, Barakat A, Al-Qurashi N, Ghabbour HA, Fun H-K. Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions. Molecules. 2016; 21(1):12. https://doi.org/10.3390/molecules21010012

Chicago/Turabian Style

El Ashry, El S.H.; El Kilany, Yeldez; Nahas, Nariman M.; Barakat, Assem; Al-Qurashi, Nadia; Ghabbour, Hazem A.; Fun, Hoong-Kun. 2016. "Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions" Molecules 21, no. 1: 12. https://doi.org/10.3390/molecules21010012

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