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Molecules 2016, 21(1), 12;

Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 November 2015 / Revised: 30 November 2015 / Accepted: 1 December 2015 / Published: 22 December 2015
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [2638 KB, uploaded 22 December 2015]   |  


Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively. View Full-Text
Keywords: benzimidazole-thione; thiazino[3,2-a]benzimidazole; X-ray benzimidazole-thione; thiazino[3,2-a]benzimidazole; X-ray

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El Ashry, E.S.H.; El Kilany, Y.; Nahas, N.M.; Barakat, A.; Al-Qurashi, N.; Ghabbour, H.A.; Fun, H.-K. Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions. Molecules 2016, 21, 12.

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