Molecules 2016, 21(1), 12; https://doi.org/10.3390/molecules21010012
Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
El Sayed H. El Ashry 1,†,*
, Yeldez El Kilany 1,2,†, Nariman M. Nahas 2,†, Assem Barakat 1,3,†, Nadia Al-Qurashi 2,†, Hazem A. Ghabbour 4,†and Hoong-Kun Fun 4,â€
, Yeldez El Kilany 1,2,†, Nariman M. Nahas 2,†, Assem Barakat 1,3,†, Nadia Al-Qurashi 2,†, Hazem A. Ghabbour 4,†and Hoong-Kun Fun 4,†1
Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt
2
Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia
3
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
4
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
â€
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 November 2015 / Revised: 30 November 2015 / Accepted: 1 December 2015 / Published: 22 December 2015
(This article belongs to the Section Organic Chemistry)
Abstract
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively. View Full-TextKeywords:
benzimidazole-thione; thiazino[3,2-a]benzimidazole; X-ray
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
El Ashry, E.S.H.; El Kilany, Y.; Nahas, N.M.; Barakat, A.; Al-Qurashi, N.; Ghabbour, H.A.; Fun, H.-K. Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions. Molecules 2016, 21, 12.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Molecules
EISSN 1420-3049
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert