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Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells

1
Division of Marine Bioscience, Korea Maritime & Ocean University, Busan 606-791, Korea
2
Department of Food and Nutrition, Silla University, Busan 617-736, Korea
3
Research and Development Division, Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712-260, Korea
4
Food and Safety Research Center, National Fisheries Research & Development Institute, Busan 619-705, Korea
5
Ocean Science & Technology School, Korea Maritime & Ocean University, Busan 606-791, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Molecules 2015, 20(8), 14474-14486; https://doi.org/10.3390/molecules200814474
Received: 11 June 2015 / Revised: 14 July 2015 / Accepted: 30 July 2015 / Published: 10 August 2015
(This article belongs to the Section Medicinal Chemistry)
The inhibitory effect of three chromones 13 and two coumarins 45 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E2 (PGE2) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). View Full-Text
Keywords: Corydalis heterocarpa; heterocarpin; furochromone; anti-inflammatory effect Corydalis heterocarpa; heterocarpin; furochromone; anti-inflammatory effect
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MDPI and ACS Style

Kim, Y.A.; Kong, C.-S.; Park, H.H.; Lee, E.; Jang, M.-S.; Nam, K.-H.; Seo, Y. Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells. Molecules 2015, 20, 14474-14486.

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