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Keywords = heterocarpin

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13 pages, 1198 KiB  
Article
Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells
by You Ah Kim, Chang-Suk Kong, Hyo Hyun Park, Eunkyung Lee, Mi-Soon Jang, Ki-Ho Nam and Youngwan Seo
Molecules 2015, 20(8), 14474-14486; https://doi.org/10.3390/molecules200814474 - 10 Aug 2015
Cited by 20 | Viewed by 6150
Abstract
The inhibitory effect of three chromones 13 and two coumarins 45 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its [...] Read more.
The inhibitory effect of three chromones 13 and two coumarins 45 on the production of nitric oxide (NO) was evaluated in LPS-induced RAW 264.7 macrophage cells. Among the compounds tested heterocarpin (1), a furochromone, significantly inhibited its production in a dose-dependent manner. In addition, heterocarpin suppressed prostaglandin E2 (PGE2) production and expression of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Full article
(This article belongs to the Section Medicinal Chemistry)
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