Next Article in Journal
Ameliorating the Effect of Astragaloside IV on Learning and Memory Deficit after Chronic Cerebral Hypoperfusion in Rats
Next Article in Special Issue
The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides
Previous Article in Journal
Antimicrobial and Seasonal Evaluation of the Carvacrol-Chemotype Oil from Lippia origanoides Kunth.
Previous Article in Special Issue
Insecticidal Activities of Bark, Leaf and Seed Extracts of Zanthoxylum heitzii against the African Malaria Vector Anopheles gambiae
Open AccessReview

Natural Products as Leads in Schistosome Drug Discovery

1
LabMol—Laboratory for Drug Design and Molecular Modeling, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia 74605-170, Brazil
2
GenoBio—Laboratory of Genomics and Biotechnology, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia 74605-050, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Molecules 2015, 20(2), 1872-1903; https://doi.org/10.3390/molecules20021872
Received: 12 December 2014 / Revised: 31 December 2014 / Accepted: 14 January 2015 / Published: 23 January 2015
Schistosomiasis is a neglected parasitic tropical disease that claims around 200,000 human lives every year. Praziquantel (PZQ), the only drug recommended by the World Health Organization for the treatment and control of human schistosomiasis, is now facing the threat of drug resistance, indicating the urgent need for new effective compounds to treat this disease. Therefore, globally, there is renewed interest in natural products (NPs) as a starting point for drug discovery and development for schistosomiasis. Recent advances in genomics, proteomics, bioinformatics, and cheminformatics have brought about unprecedented opportunities for the rapid and more cost-effective discovery of new bioactive compounds against neglected tropical diseases. This review highlights the main contributions that NP drug discovery and development have made in the treatment of schistosomiasis and it discusses how integration with virtual screening (VS) strategies may contribute to accelerating the development of new schistosomidal leads, especially through the identification of unexplored, biologically active chemical scaffolds and structural optimization of NPs with previously established activity. View Full-Text
Keywords: schistosomiasis; natural products; leads; chemical scaffolds; virtual screening schistosomiasis; natural products; leads; chemical scaffolds; virtual screening
Show Figures

Figure 1

MDPI and ACS Style

Neves, B.J.; Andrade, C.H.; Cravo, P.V.L. Natural Products as Leads in Schistosome Drug Discovery. Molecules 2015, 20, 1872-1903.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop