4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles
1
Regional Centre of Advanced Technologies and Materials, Department of Inorganic Chemistry, Faculty of Science, Palacký University, 17. listopadu 12, Olomouc CZ 77146, Czech Republic
2
Regional Centre of Advanced Technologies and Materials, Department of Experimental Physics, Faculty of Science, Palacký University, 17. listopadu 12, Olomouc CZ 77146, Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(2), 1622-1634; https://doi.org/10.3390/molecules19021622
Received: 23 December 2013 / Revised: 17 January 2014 / Accepted: 23 January 2014 / Published: 28 January 2014
(This article belongs to the Section Medicinal Chemistry)
Abstract
This study describes a one-pot synthesis of superparamagnetic maghemite-based 4-aminobenzoic acid-coated spherical core-shell nanoparticles ([email protected]) as suitable nanocomposites potentially usable as magnetic carriers for drug delivery. The [email protected] system was subsequently functionalized by the activated species (1* and 2*) of highly in vitro cytotoxic cis-[PtCl2(3Claza)2] (1; 3Claza stands for 3-chloro-7-azaindole) or cis-[PtCl2(5Braza)2] (2; 5Braza stands for 5-bromo-7-azaindole), which were prepared by a silver(I) ion assisted dechlorination of the parent dichlorido complexes. The products 1*@[email protected] and 2*@[email protected], as well as an intermediate [email protected], were characterized by a combination of various techniques, such as Mössbauer, FTIR and EDS spectroscopy, thermal analysis, SEM and TEM. The results showed that the products consist of well-dispersed maghemite-based nanoparticles of 13 nm average size that represent an easily obtainable system for delivery of highly cytotoxic cisplatin-like complexes in oncological practice. View Full-TextKeywords:
maghemite; nanoparticles; magnetic; platinum complexes; 7-azaindole derivatives; drug delivery
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Štarha, P.; Stavárek, M.; Tuček, J.; Trávníček, Z. 4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles. Molecules 2014, 19, 1622-1634.
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