Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
Abstract
:1. Introduction
2. β-Pyridopyrrolopyrimidine Alkaloids: Variolins, a New Family of Cyclin-Dependent Kinases (CDKs) Inhibitors
3. Indole Alkaloids: Meridianins, a New Scaffold for the Design of Novel CDK Inhibitors
4. Bis-Steroidal Pyrazines: Ritterazines and Cephalostatins, Potent Inducers of Apoptosis Acting via a Novel Antimitotic Mechanism
Ritterazine | (ED50 nM) | Cephalostatin | (ED50 nM) | Ritterazine | (ED50 nM) | Cephalostatin | (ED50 nM) |
---|---|---|---|---|---|---|---|
A | l4.2 | 1 | 10−4–10−6 | N | 522 | 14 | 4.4 |
B | 0.17 | 2 | 10−4–10−6 | O | 2383 | 15 | 26.2 |
C | 102.3 | 3 | 10−4–10−6 | P | 819 | 16 | <1.1 |
D | 17.5 | 4 | 10−4–10−6 | Q | 657 | 17 | 4.4 |
E | 3.8 | 5 | 42.5 | R | 2461 | 18 | 4.6 |
F | 0.81 | 6 | 2.3 | S | 539 | 19 | 7.9 |
G | 0.81 | 7 | 1–<0.1 | T | 522 | ||
H | 17.8 | 8 | 1–<0.1 | U | 2341 | ||
I | 15.3 | 9 | 1–<0.1 | V | 2341 | ||
J | 14.0 | 10 | 3.2 | W | 3631 | ||
K | 10.4 | 11 | 2.7 | X | 3404 | ||
L | 11.1 | 12 | 76.2 | Y | 4.0 | ||
M | 16.7 | 13 | 47.9 | Z | 2200 |
5. Dopa [2-Amino,3-(3',4'-dihydroxyphenyl) Propionic Acid] Derived Pyrrole Alkaloids: Lamellarins, Potent Inhibitors of Topoisomerase (TOPO) I with Multi-Drug Resistance (MDR) Modulating Activity
6. Tetrahydroisoquinoline Alkaloids: Ecteinascidins, a New Class of DNA Binding Agents
7. Pyridoacridine Alkaloids: DNA Intercalating Agents with Reactive Oxygen Species (ROS) Producing and TOPO-Inhibiting Activities
8. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Imperatore, C.; Aiello, A.; D'Aniello, F.; Senese, M.; Menna, M. Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development. Molecules 2014, 19, 20391-20423. https://doi.org/10.3390/molecules191220391
Imperatore C, Aiello A, D'Aniello F, Senese M, Menna M. Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development. Molecules. 2014; 19(12):20391-20423. https://doi.org/10.3390/molecules191220391
Chicago/Turabian StyleImperatore, Concetta, Anna Aiello, Filomena D'Aniello, Maria Senese, and Marialuisa Menna. 2014. "Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development" Molecules 19, no. 12: 20391-20423. https://doi.org/10.3390/molecules191220391