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Open AccessArticle

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2
School of Nutrition, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan
3
Research Center for Natural Product and New Drug, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
5
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
6
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
7
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
8
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
9
Research and Development Center of Chinese Herbal Medicines and New Drugs, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
10
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80708, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(12), 20382-20390; https://doi.org/10.3390/molecules191220382
Received: 27 October 2014 / Revised: 25 November 2014 / Accepted: 27 November 2014 / Published: 5 December 2014
(This article belongs to the Section Natural Products Chemistry)
Four new sulfur-containing compounds, named clinamides A-C (13), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR. View Full-Text
Keywords: Clinacanthus nutans; sulfur-containing compound Clinacanthus nutans; sulfur-containing compound
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Tu, S.-F.; Liu, R.H.; Cheng, Y.-B.; Hsu, Y.-M.; Du, Y.-C.; El-Shazly, M.; Wu, Y.-C.; Chang, F.-R. Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts. Molecules 2014, 19, 20382-20390.

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