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Molecules 2014, 19(12), 19665-19677;

Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 15 October 2014 / Revised: 20 November 2014 / Accepted: 21 November 2014 / Published: 27 November 2014
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst. View Full-Text
Keywords: bis(indolyl)methanes; tandem protocol; biocatalysis; promiscuity; α-chymotrypsin bis(indolyl)methanes; tandem protocol; biocatalysis; promiscuity; α-chymotrypsin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xie, Z.-B.; Sun, D.-Z.; Jiang, G.-F.; Le, Z.-G. Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin. Molecules 2014, 19, 19665-19677.

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