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Open AccessArticle

Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin

Department of Applied Chemistry, East China Institute of Technology, Nanchang 330013, China
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2014, 19(12), 19665-19677; https://doi.org/10.3390/molecules191219665
Received: 15 October 2014 / Revised: 20 November 2014 / Accepted: 21 November 2014 / Published: 27 November 2014
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
A mild and efficient method catalyzed by α-chymotrypsin was developed for the synthesis of bis(indolyl)methanes through a cascade process between indole and aromatic aldehydes. In the ethanol aqueous solution, a green medium, a wide range of aromatic aldehydes could react with indole to afford the desired products with moderate to good yields (from 68% to 95%) using a little α-chymotrypsin as catalyst. View Full-Text
Keywords: bis(indolyl)methanes; tandem protocol; biocatalysis; promiscuity; α-chymotrypsin bis(indolyl)methanes; tandem protocol; biocatalysis; promiscuity; α-chymotrypsin
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MDPI and ACS Style

Xie, Z.-B.; Sun, D.-Z.; Jiang, G.-F.; Le, Z.-G. Facile Synthesis of Bis(indolyl)methanes Catalyzed by α-Chymotrypsin. Molecules 2014, 19, 19665-19677.

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