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Molecules 2014, 19(1), 641-650;

Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model

Department of Chemistry, Tamkang University, 151, Yingzhuan Road, Danshui Dist., New Taipei City 25137, Taiwan
Department of Anatomy, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
Department of Applied Chemistry, National Chia-Yi University, Chia-Yi 60004, Taiwan
Authors to whom correspondence should be addressed.
Received: 31 October 2013 / Revised: 4 December 2013 / Accepted: 17 December 2013 / Published: 7 January 2014
(This article belongs to the Section Medicinal Chemistry)
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The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1ad were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos. View Full-Text
Keywords: chalcone; embryogenesis; muscle; toxicity; zebrafish chalcone; embryogenesis; muscle; toxicity; zebrafish

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Lee, Y.-T.; Fong, T.-H.; Chen, H.-M.; Chang, C.-Y.; Wang, Y.-H.; Chern, C.-Y.; Chen, Y.-H. Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model. Molecules 2014, 19, 641-650.

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