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First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

1
Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil
2
Department of Physiology and Pathology, Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil
3
Institute for Scientific and Technological Research of Amapá, Macapá, AP 68901-025, Brazil
4
Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro-UFRRJ, Campos dos Goytacazes, RJ 28013-602, Brazil
5
Postgraduate Program in Development and Technological Innovation in Drug-Center for Health Sciences, Federal University of Paraíba, João Pessoa, PB 58051-970, Brazil
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(9), 11086-11099; https://doi.org/10.3390/molecules180911086
Received: 21 June 2013 / Revised: 29 August 2013 / Accepted: 29 August 2013 / Published: 10 September 2013
(This article belongs to the Section Metabolites)
The phytochemical study of Cordia exaltata Lam. (Boraginaceae) led to the isolation, through chromatographic techniques, of nineteen secondary metabolites: 8,8'dimethyl-3,4,3',4'-dimethylenedioxy-7-oxo-2,7'cyclolignan (1), 8,8'-dimethyl-4,5-dimethoxy-3',4'-methylenodioxy-7-oxo-2,7'cyclolignan (2), sitosterol (3a), stigmasterol (3b), sitosterol-3-O-β-d-glucopyranoside (4a), stigmasterol-3-O-β-d-glucopyranoside (4b), phaeophytin A (5), 132-hydroxyphaeophytin A (6), 173-ethoxypheophorbide A (7), 132-hydroxy-173-ethoxypheophorbide A (8), m-methoxy-p-hydroxybenzaldehyde (9), (E)-7-(3,4-dihydroxyphenyl)-7-propenoic acid (10), 1-benzopyran-2-one (11), 7-hydroxy-1-benzopyran-2-one (12), 2,5-bis-(3',4'-methylenedioxiphenyl)-3,4-dimethyltetrahydrofuran (13), 3,4,5,3',5'-pentamethoxy-1'-allyl-8.O.4'-neolignan (14), 3,5,7,3',4'-pentahydroxyflavonol (15), 5,7-dihydroxy-4'-methoxyflavone (16), 5,8-dihydroxy-7,4’-dimethoxyflavone (17), kaempherol 3-O-β-d-glucosyl-6''-α-L-ramnopyranoside (18) and kaempherol 3,7-di-O-α-l-ramnopyranoside (19). Their structures were identified by 1H and 13C-NMR using one and two-dimensional techniques. In addition, the antimicrobial activity of compounds 1, 2, 13 and 14 against bacteria and fungi are reported here for the first time. View Full-Text
Keywords: phytochemical study; Cordia exaltata Lam.; Boraginaceae; antimicrobial activity phytochemical study; Cordia exaltata Lam.; Boraginaceae; antimicrobial activity
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Bezerra de Sá de Sousa Nogueira, T.; Bezerra de Sá de Sousa Nogueira, R.; Antas e Silva, D.; Tavares, J.F.; De Oliveira Lima, E.; De Oliveira Pereira, F.; De Souza Fernandes, M.M.M.; De Medeiros, F.A.; Do Socorro Ferreira Rodrigues Sarquis, R.D.S.F.R.; Filho, R.B.; Da Silva Maciel, J.K.; De Fátima Vanderlei de Souza, M. First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans. Molecules 2013, 18, 11086-11099.

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