Next Article in Journal
Two New Compounds Isolated from Liriope muscari
Previous Article in Journal
Optimization of Enzymatic Process for Vanillin Extraction Using Response Surface Methodology
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(8), 8762-8772; https://doi.org/10.3390/molecules17088762

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives

1
Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India
2
Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, AP, India
3
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1-1, Jen-Ai Road, Taipei 100, Taiwan
4
Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 June 2012 / Revised: 16 July 2012 / Accepted: 18 July 2012 / Published: 25 July 2012
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [270 KB, uploaded 18 June 2014]   |  

Abstract

A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells. View Full-Text
Keywords: triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top