Molecules 2012, 17(8), 8762-8772; https://doi.org/10.3390/molecules17088762
Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
Kumaraswamy Sorra 1,2,†, Chi-Fen Chang 3,†, Srinivas Pusuluri 1, Khagga Mukkanti 2, Min-Chiau Laiu 4, Bo-Ying Bao 5, Chia-Hao Su 4,*
and Ta-Hsien Chuang 5,*
1
Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India
2
Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, AP, India
3
Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, 1-1, Jen-Ai Road, Taipei 100, Taiwan
4
Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
â€
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 June 2012 / Revised: 16 July 2012 / Accepted: 18 July 2012 / Published: 25 July 2012
(This article belongs to the Section Medicinal Chemistry)
Abstract
A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells. View Full-TextKeywords:
triazolopyrrolobenzodiazepine; Lawesson’s reagent; cytotoxicity; Mahlavu celles; MRC-5 cells
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Sorra, K.; Chang, C.-F.; Pusuluri, S.; Mukkanti, K.; Laiu, M.-C.; Bao, B.-Y.; Su, C.-H.; Chuang, T.-H. Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives. Molecules 2012, 17, 8762-8772.
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