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Keywords = triazolopyrrolobenzodiazepine

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11 pages, 270 KiB  
Article
Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) Derivatives
by Kumaraswamy Sorra, Chi-Fen Chang, Srinivas Pusuluri, Khagga Mukkanti, Min-Chiau Laiu, Bo-Ying Bao, Chia-Hao Su and Ta-Hsien Chuang
Molecules 2012, 17(8), 8762-8772; https://doi.org/10.3390/molecules17088762 - 25 Jul 2012
Cited by 7 | Viewed by 4906
Abstract
A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the [...] Read more.
A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells. Full article
(This article belongs to the Section Medicinal Chemistry)
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