An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Comparison of the ROS-Scavenging Ability of Flavone and Aminoflavones 10, 11, and 12
2.3. Flavone and Diaminoflavones Protecting Zebrafish Cells from UV-Induced Apoptosis
3. Experimental
3.1. General
3.2. Synthetic Procedures for the Key Intermediates and Aminoflavones 10, 11, and 12
3.3. Evaluation
3.3.1. Methods for Fish Embryos Maintenance, Chemicals Treatment and Survival Rates Analysis
3.3.2. UVB Exposure, ROS Detection and Data Analysis
4. Conclusions
Acknowledgments
Conflict of Interest
References and Notes
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- Sample Availability: Samples of the compounds 4−12 are available from the authors.
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Shih, T.-L.; Hsiao, C.-A.; Lin, Z.-Y.; Chen, Y.-H. An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae. Molecules 2012, 17, 8206-8216. https://doi.org/10.3390/molecules17078206
Shih T-L, Hsiao C-A, Lin Z-Y, Chen Y-H. An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae. Molecules. 2012; 17(7):8206-8216. https://doi.org/10.3390/molecules17078206
Chicago/Turabian StyleShih, Tzenge-Lien, Chih-Ang Hsiao, Zi-Yu Lin, and Yau-Hung Chen. 2012. "An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae" Molecules 17, no. 7: 8206-8216. https://doi.org/10.3390/molecules17078206