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Open AccessArticle

Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells

1
Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China
2
Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2012, 17(12), 15013-15021; https://doi.org/10.3390/molecules171215013
Received: 12 November 2012 / Revised: 6 December 2012 / Accepted: 11 December 2012 / Published: 18 December 2012
Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 113 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids 14 and lignans 57 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD. View Full-Text
Keywords: Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell
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Wang, Q.; Wang, C.; Zuo, Y.; Wang, Z.; Yang, B.; Kuang, H. Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells. Molecules 2012, 17, 15013-15021.

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