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Keywords = heishuixiecaoline

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9 pages, 287 KiB  
Article
Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
by Qiuhong Wang, Changfu Wang, Yueming Zuo, Zhibin Wang, Bingyou Yang and Haixue Kuang
Molecules 2012, 17(12), 15013-15021; https://doi.org/10.3390/molecules171215013 - 18 Dec 2012
Cited by 36 | Viewed by 6576
Abstract
Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on [...] Read more.
Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 113 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids 14 and lignans 57 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD. Full article
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