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Keywords = Valeriana amurensis

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12 pages, 1818 KB  
Article
Neuroprotective Iridoids and Lignans from Valeriana amurensis
by Minhui Ye, Xiaoju Lin, Qiuhong Wang, Bingyou Yang and Changfu Wang
Molecules 2023, 28(15), 5793; https://doi.org/10.3390/molecules28155793 - 1 Aug 2023
Cited by 4 | Viewed by 2363
Abstract
Valeriana amurensis (V. amurensis) is widely distributed in Northeast China. In addition to medicines, it has also been used to prepare food, wine, tobacco, cosmetics, perfume, and functional foods. Other studies have investigated the neuroprotective effects of V. amurensis extract. As [...] Read more.
Valeriana amurensis (V. amurensis) is widely distributed in Northeast China. In addition to medicines, it has also been used to prepare food, wine, tobacco, cosmetics, perfume, and functional foods. Other studies have investigated the neuroprotective effects of V. amurensis extract. As the therapeutic basis, the active constituents should be further evaluated. In this paper, six new compounds (16) were isolated, including five iridoids (Xiecaoiridoidside A–E) and one bisepoxylignan (Xiecaolignanside A), as well as six known compounds (712). The neuroprotective effects of 112 were also investigated with amyloid β protein 142 (Aβ1-42)-induced injury to rat pheochromocytoma (PC12) cells. As a result, iridoids 1 and 2 and lignans 6, 8, and 9 could markedly maintain the cells’ viability by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) and lactate dehydrogenase (LDH) release assay. Full article
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13 pages, 1992 KB  
Article
An Effective Chromatography Process for Simultaneous Purification and Separation of Total Lignans and Flavonoids from Valeriana amurensis
by Manli Zhang, Bingyou Yang, Minhui Ye, Jianqing Chen, Yan Liu and Changfu Wang
Molecules 2022, 27(23), 8598; https://doi.org/10.3390/molecules27238598 - 6 Dec 2022
Cited by 7 | Viewed by 2892
Abstract
An effective chromatography process was developed and validated for simultaneous purification and separation of total lignans and flavonoids from Valeriana amurensis. The total lignans and flavonoids in Valeriana amurensis extract were prepurified with macroporous resin column chromatography, and the conditions were optimized [...] Read more.
An effective chromatography process was developed and validated for simultaneous purification and separation of total lignans and flavonoids from Valeriana amurensis. The total lignans and flavonoids in Valeriana amurensis extract were prepurified with macroporous resin column chromatography, and the conditions were optimized as follows: 40 mg/mL Valeriana amurensis extract (2.0 g) solution was loaded onto an AB-8 resin column with a diameter-to-height ratio of 1:7, followed by adsorption for 6 h; then, the column was eluted successively with 5 BV water and 10% and 50% ethanol at a flow rate 2 BV/h. The obtained 50% ethanol fraction was further repurified and separated by polyamide resin column chromatography to obtain the total lignans and flavonoids, respectively. The chromatography conditions were optimized as follows: a 50% ethanol fraction (1.0 g) was mixed with 1.0 g polyamide resin and loaded onto a polyamide resin (60–100 mesh) column with a diameter-to-height ratio of 1:3; then, the column was eluted successively with 6 BV water and 40% and 80% ethanol at a flow rate of 4 BV/h. The total lignans and flavonoids were obtained from water and 80% ethanol fraction, respectively. The content and recovery of standard compounds in total lignans and flavonoids were analyzed with HPLC-PDA, and the feasibility of the process was confirmed. Full article
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6 pages, 785 KB  
Proceeding Paper
Essential Oils and Volatiles as Nematodicides against the Cyst Nematodes Globodera and Heterodera 
by Jorge M. S. Faria and Cláudia Vicente
Biol. Life Sci. Forum 2021, 3(1), 1; https://doi.org/10.3390/IECAG2021-09689 - 1 May 2021
Cited by 5 | Viewed by 2019
Abstract
The cyst nematodes of the genera Heterodera (HET) and Globodera (GLO) are among the most damaging obligate plant parasitic nematodes (PPNs) that parasitize cereals, rice, potatoes and soybean. In the absence of resistant crops, soil fumigation of pesticides provides a good strategy for [...] Read more.
The cyst nematodes of the genera Heterodera (HET) and Globodera (GLO) are among the most damaging obligate plant parasitic nematodes (PPNs) that parasitize cereals, rice, potatoes and soybean. In the absence of resistant crops, soil fumigation of pesticides provides a good strategy for population control. However, synthetic nematicides can cause negative environmental and public health impacts and are feared to lead to the development of resistance and immunity. The use of essential oils (EOs) could be a viable environmentally friendly alternative, which has been poorly explored on cyst nematodes but has shown very good results on other PPNs. The present work reviews the existing bibliography on the biological activity of EOs against GLO and HET. EOs from Allium sativum, Eucalyptus globulus, and Salvia officinalis were the most active against GLO egg hatching. The EOs extracted from Hyssopus cuspidatus, Kaempferia galanga, Menthacanadensis, Ocimum basilicum, and Valeriana amurensis had the highest activity against HET J2 juveniles. Ethyl p-methoxycinnamate, a phenylpropanoid ester, was the EO volatile with the highest toxicity against HET, showing lower EC50 values than the nematodicide fosthiazate. The study of EOs against cyst nematodes is still preliminary in comparison to other PPNs. Future works must expand this line of research and explore greener practices in cyst nematode pest management. Full article
(This article belongs to the Proceedings of The 1st International Electronic Conference on Agronomy)
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9 pages, 287 KB  
Article
Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
by Qiuhong Wang, Changfu Wang, Yueming Zuo, Zhibin Wang, Bingyou Yang and Haixue Kuang
Molecules 2012, 17(12), 15013-15021; https://doi.org/10.3390/molecules171215013 - 18 Dec 2012
Cited by 40 | Viewed by 7117
Abstract
Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on [...] Read more.
Three new germacrane-type sesquiterpenoids, heishuixiecaoline A–C (compounds 13), were isolated along with ten known compounds 413 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer’s disease (AD). The structures of 13 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 113 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ25–25), respectively. As a result, germacrane-type sesquiterpenoids 14 and lignans 57 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD. Full article
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