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Molecules 2012, 17(12), 14841-14845;

A General Synthesis of Bis-indolylpiperazine-2,5-diones

Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA
Department of Chemistry, Georgia Southern University, P.O. Box 8064, Statesboro, GA 30460, USA
Author to whom correspondence should be addressed.
Received: 15 November 2012 / Revised: 5 December 2012 / Accepted: 5 December 2012 / Published: 13 December 2012
(This article belongs to the Section Organic Chemistry)
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The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by 1H-NMR. View Full-Text
Keywords: indole; bromination; dragmacidin derivatives indole; bromination; dragmacidin derivatives

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Crooke, S.; Whitlock, C. A General Synthesis of Bis-indolylpiperazine-2,5-diones. Molecules 2012, 17, 14841-14845.

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