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Molecules 2011, 16(5), 3701-3712;

Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland
Department of Conservative Dentistry and Endodontics Division of Dental Propedeutics, Medical University of Silesia in Katowice, Plac Akademicki 17, 41-902 Bytom, Poland
Author to whom correspondence should be addressed.
Received: 9 March 2011 / Revised: 27 April 2011 / Accepted: 29 April 2011 / Published: 3 May 2011
(This article belongs to the Collection Bioactive Compounds)
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Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ– or PMA– stimulated RAW264.7 macrophages. View Full-Text
Keywords: neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages neobavaisoflavone; anti-inflammatory activity; RAW264.7 macrophages

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Szliszka, E.; Skaba, D.; Czuba, Z.P.; Krol, W. Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages. Molecules 2011, 16, 3701-3712.

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