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Open AccessArticle

Polycationic Glycosides

Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA
Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA
Author to whom correspondence should be addressed.
Molecules 2011, 16(2), 1508-1518;
Received: 23 December 2010 / Revised: 7 February 2011 / Accepted: 10 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Glycosides)
Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented. View Full-Text
Keywords: polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial
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MDPI and ACS Style

Engel, R.; Ghani, I.; Montenegro, D.; Thomas, M.; Klaritch-Vrana, B.; Castaño, A.; Friedman, L.; Leb, J.; Rothman, L.; Lee, H.; Capodiferro, C.; Ambinder, D.; Cere, E.; Awad, C.; Sheikh, F.; Rizzo, J.; Nisbett, L.-M.; Testani, E.; Melkonian, K. Polycationic Glycosides. Molecules 2011, 16, 1508-1518.

AMA Style

Engel R, Ghani I, Montenegro D, Thomas M, Klaritch-Vrana B, Castaño A, Friedman L, Leb J, Rothman L, Lee H, Capodiferro C, Ambinder D, Cere E, Awad C, Sheikh F, Rizzo J, Nisbett L-M, Testani E, Melkonian K. Polycationic Glycosides. Molecules. 2011; 16(2):1508-1518.

Chicago/Turabian Style

Engel, Robert; Ghani, Ishrat; Montenegro, Diego; Thomas, Marie; Klaritch-Vrana, Barbara; Castaño, Alejandra; Friedman, Laura; Leb, Jay; Rothman, Leah; Lee, Heidi; Capodiferro, Craig; Ambinder, Daniel; Cere, Eva; Awad, Christopher; Sheikh, Faiza; Rizzo, JaimeLee; Nisbett, Lisa-Marie; Testani, Erika; Melkonian, Karin. 2011. "Polycationic Glycosides" Molecules 16, no. 2: 1508-1518.

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