Topical Collection "Ochratoxins"

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A topical collection in Toxins (ISSN 2072-6651). This collection belongs to the section "Mycotoxins".

Editors

Collection Editor
Prof. Dr. Richard A. Manderville
Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
Website: http://www.chembio.uoguelph.ca/manderville/
E-Mail: rmanderv@uoguelph.ca
Phone: +1 519 824 4120
Fax: +1 519 766 1499
Interests: DNA damage by phenolic toxins including ochratoxin A; Modified DNA bases as fluorescent probes

Collection Editor
Prof. Dr. Annie Pfohl-Leszkowicz
National Agronomical High School of Toulouse (ENSAT), Unit of Toxicology & Food safety, 1 avenue de l’Agrobiopôle, BP 32607, 31326, Auzeville-Tolosane, France
E-Mail: leszkowicz@ensat.fr
Phone: +33 534 323 947
Fax: +33 534 323 947
Interests: mycotoxin; ochratoxin; fumonisin; zearalenone; biomarker; risk evaluation; environmental toxicology; polycyclic aromatic compounds; genotoxicity; DNA adduct; balkan endemic nephropathy; kidney cancer; biotransformation

Topical Collection Information

Dear Colleagues,

In the seminal paper published in Nature, 1965, van Der Merwe, Steyn, Fourie, Scott and Theron, reported the isolation of a new toxic metabolite, called ochratoxin A (now abbreviated OTA), from Aspergillus ochraceus. Structural analysis of the mycotoxin pointed to the presence of a chlorophenolic moiety containing a dihydroisocoumarin system amide-linked to L-phenylalanine with toxicity in ducklings of the same order as that of aflatoxin B1 from Aspergillus flavus. Subsequent experimental carcinogenicity studies in male rats and mice carried out in the 1980s and later (2000) in poultry demonstrated OTA to be a potent kidney carcinogen and highlighted the real possibility that OTA could be a human carcinogen. OTA causes kidney damage in farm animals and a number of studies also suggested a correlation between OTA exposure and a fatal human kidney disease called Balkan endemic nephropathy, in which patients exhibit a high incidence of urinary tract tumours. OTA is now regarded as the most toxic member of the ochratoxins, which have attracted considerable attention since they are one of the most abundant food-contaminating mycotoxins in the world and are classified as potentially carcinogenic to humans (Group 2B). Recently it has been also pinpointed that the toxic effects of OTA was increased by other mycotoxins. Ongoing interdisciplinary research on the ochratoxins have been concerned with detection in feed and human foodstuff, occurrence and estimation of dietary and inhalation intake, establishment of limits for human consumption based on risk assessment, understanding mechanisms of toxicity for the development of detoxification processes and determining the toxic effects of OTA in the presence of other mycotoxins. We hope that this collection of Toxins entitled “Ochratoxins” will provide the readership with a better understanding of the key issues being addressed at the present time.

Prof. Dr. Richard A. Manderville
Prof. Dr. Annie Pfohl-Leszkowicz
Editors

Manuscript Submission Information

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Keywords

• ochratoxins
• mycotoxin
• carcinogen
• Balkan endemic nephropathy
• DNA damage
• genotoxic
• intake
• biotransformation
• food
• risk assessment
• coexposure
• detoxification
• biomarkers
• inhalation

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Published Papers (42 papers)

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2014  ( 1 paper )


2013  ( 9 papers )


2012  ( 1 paper )


2010  ( 31 papers )


2014
by  and
Toxins 2014, 6(1), 371-379; doi:10.3390/toxins6010371
Received: 11 November 2013; in revised form: 10 January 2014 / Accepted: 14 January 2014 / Published: 20 January 2014
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2013
by , , , , ,  and
Toxins 2013, 5(12), 2671-2685; doi:10.3390/toxins5122671
Received: 29 October 2013; in revised form: 2 December 2013 / Accepted: 4 December 2013 / Published: 18 December 2013
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by , , , ,  and
Toxins 2013, 5(12), 2324-2340; doi:10.3390/toxins5122324
Received: 15 September 2013; in revised form: 21 November 2013 / Accepted: 22 November 2013 / Published: 28 November 2013
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by , ,  and
Toxins 2013, 5(11), 1988-2008; doi:10.3390/toxins5111988
Received: 25 August 2013; in revised form: 24 October 2013 / Accepted: 28 October 2013 / Published: 5 November 2013
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by ,  and
Toxins 2013, 5(11), 1965-1987; doi:10.3390/toxins5111965
Received: 24 August 2013; in revised form: 24 October 2013 / Accepted: 28 October 2013 / Published: 1 November 2013
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by , , ,  and
Toxins 2013, 5(10), 1827-1844; doi:10.3390/toxins5101827
Received: 30 July 2013; in revised form: 10 October 2013 / Accepted: 11 October 2013 / Published: 22 October 2013
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by , , , ,  and
Toxins 2013, 5(10), 1742-1766; doi:10.3390/toxins5101742
Received: 29 July 2013; in revised form: 25 September 2013 / Accepted: 27 September 2013 / Published: 11 October 2013
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by  and
Toxins 2013, 5(9), 1503-1530; doi:10.3390/toxins5091503
Received: 11 July 2013; in revised form: 24 August 2013 / Accepted: 26 August 2013 / Published: 4 September 2013
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by ,  and
Toxins 2013, 5(7), 1282-1298; doi:10.3390/toxins5071282
Received: 17 May 2013; in revised form: 19 June 2013 / Accepted: 8 July 2013 / Published: 19 July 2013
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by ,  and
Toxins 2013, 5(6), 1202-1218; doi:10.3390/toxins5061202
Received: 2 May 2013; in revised form: 13 June 2013 / Accepted: 13 June 2013 / Published: 21 June 2013
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2012
by , , , ,  and
Toxins 2012, 4(12), 1535-1551; doi:10.3390/toxins4121535
Received: 8 October 2012; in revised form: 27 November 2012 / Accepted: 6 December 2012 / Published: 14 December 2012
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2010
by ,  and
Toxins 2010, 2(11), 2593-2605; doi:10.3390/toxins2112593
Received: 9 September 2010; in revised form: 28 September 2010 / Accepted: 26 October 2010 / Published: 29 October 2010
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by
Toxins 2010, 2(10), 2333-2336; doi:10.3390/toxins2102333
Received: 2 September 2010; in revised form: 9 September 2010 / Accepted: 21 September 2010 / Published: 29 September 2010
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by ,  and
Toxins 2010, 2(10), 2337-2339; doi:10.3390/toxins2102337
Received: 17 September 2010; Accepted: 28 September 2010 / Published: 29 September 2010
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by ,  and
Toxins 2010, 2(9), 2230-2241; doi:10.3390/toxins2092230
Received: 2 August 2010; in revised form: 13 August 2010 / Accepted: 23 August 2010 / Published: 26 August 2010
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by , , ,  and
Toxins 2010, 2(8), 2098-2105; doi:10.3390/toxins2082098
Received: 15 July 2010; in revised form: 3 August 2010 / Accepted: 9 August 2010 / Published: 10 August 2010
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by , , , , ,  and
Toxins 2010, 2(8), 1984-1996; doi:10.3390/toxins2081984
Received: 17 June 2010; Accepted: 28 July 2010 / Published: 3 August 2010
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by ,  and
Toxins 2010, 2(7), 1796-1824; doi:10.3390/toxins2071796
Received: 4 June 2010; in revised form: 24 June 2010 / Accepted: 6 July 2010 / Published: 8 July 2010
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by , , ,  and
Toxins 2010, 2(7), 1718-1750; doi:10.3390/toxins2071718
Received: 6 May 2010; in revised form: 25 June 2010 / Accepted: 29 June 2010 / Published: 1 July 2010
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by ,  and
Toxins 2010, 2(6), 1582-1594; doi:10.3390/toxins2061582
Received: 26 March 2010; in revised form: 8 June 2010 / Accepted: 18 June 2010 / Published: 21 June 2010
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by  and
Toxins 2010, 2(6), 1536-1553; doi:10.3390/toxins2061536
Received: 2 June 2010; in revised form: 16 June 2010 / Accepted: 17 June 2010 / Published: 18 June 2010
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by  and
Toxins 2010, 2(6), 1414-1427; doi:10.3390/toxins2061414
Received: 13 May 2010; in revised form: 7 June 2010 / Accepted: 10 June 2010 / Published: 11 June 2010
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by , , , ,  and
Toxins 2010, 2(6), 1428-1444; doi:10.3390/toxins2061428
Received: 15 April 2010; in revised form: 26 May 2010 / Accepted: 8 June 2010 / Published: 11 June 2010
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by ,  and
Toxins 2010, 2(6), 1381-1398; doi:10.3390/toxins2061381
Received: 15 April 2010; in revised form: 11 May 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
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by ,  and
Toxins 2010, 2(6), 1225-1249; doi:10.3390/toxins2061225
Received: 7 May 2010; in revised form: 17 May 2010 / Accepted: 26 May 2010 / Published: 1 June 2010
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by , , , , , , , ,  and
Toxins 2010, 2(6), 1265-1278; doi:10.3390/toxins2061265
Received: 22 April 2010; in revised form: 14 May 2010 / Accepted: 31 May 2010 / Published: 1 June 2010
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by , , , ,  and
Toxins 2010, 2(6), 1279-1299; doi:10.3390/toxins2061279
Received: 6 May 2010; in revised form: 28 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
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by ,  and
Toxins 2010, 2(5), 1111-1120; doi:10.3390/toxins2051111
Received: 16 April 2010; in revised form: 4 May 2010 / Accepted: 11 May 2010 / Published: 14 May 2010
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by
Toxins 2010, 2(5), 1121-1133; doi:10.3390/toxins2051121
Received: 2 April 2010; in revised form: 16 April 2010 / Accepted: 13 May 2010 / Published: 14 May 2010
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by  and
Toxins 2010, 2(5), 1065-1077; doi:10.3390/toxins2051065
Received: 1 March 2010; in revised form: 15 March 2010 / Accepted: 12 May 2010 / Published: 13 May 2010
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by ,  and
Toxins 2010, 2(5), 1078-1099; doi:10.3390/toxins2051078
Received: 1 April 2010; in revised form: 22 April 2010 / Accepted: 12 May 2010 / Published: 13 May 2010
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by  and
Toxins 2010, 2(5), 1100-1110; doi:10.3390/toxins2051100
Received: 9 April 2010; in revised form: 27 April 2010 / Accepted: 11 May 2010 / Published: 13 May 2010
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by , ,  and
Toxins 2010, 2(5), 1054-1064; doi:10.3390/toxins2051054
Received: 25 March 2010; in revised form: 14 April 2010 / Accepted: 11 May 2010 / Published: 12 May 2010
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by , ,  and
Toxins 2010, 2(4), 809-839; doi:10.3390/toxins204809
Received: 9 March 2010; in revised form: 12 April 2010 / Accepted: 19 April 2010 / Published: 21 April 2010
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by , , , , ,  and
Toxins 2010, 2(4), 840-855; doi:10.3390/toxins2040840
Received: 3 March 2010; in revised form: 14 April 2010 / Accepted: 20 April 2010 / Published: 21 April 2010
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by ,  and
Toxins 2010, 2(4), 758-770; doi:10.3390/toxins2040758
Received: 26 February 2010; in revised form: 9 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
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by  and
Toxins 2010, 2(4), 771-779; doi:10.3390/toxins2040771
Received: 5 March 2010; in revised form: 7 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
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by , ,  and
Toxins 2010, 2(4), 780-792; doi:10.3390/toxins2040780
Received: 17 March 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
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by
Toxins 2010, 2(4), 649-664; doi:10.3390/toxins2040649
Received: 25 February 2010; in revised form: 28 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
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by , , ,  and
Toxins 2010, 2(4), 552-571; doi:10.3390/toxins2040552
Received: 21 February 2010; in revised form: 19 March 2010 / Accepted: 30 March 2010 / Published: 31 March 2010
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by  and
Toxins 2010, 2(4), 461-493; doi:10.3390/toxins2040461
Received: 24 January 2010; in revised form: 5 March 2010 / Accepted: 8 March 2010 / Published: 29 March 2010
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by , , , , , , ,  and
Toxins 2010, 2(3), 326-340; doi:10.3390/toxins2030326
Received: 21 January 2010; in revised form: 22 February 2010 / Accepted: 24 February 2010 / Published: 9 March 2010
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Last update: 26 November 2014

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