Special Issue "Ochratoxins"

Quicklinks

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: closed (15 April 2010)

Special Issue Editors

Guest Editor
Prof. Dr. Richard A. Manderville
Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
Website: http://www.chembio.uoguelph.ca/manderville/
E-Mail: rmanderv@uoguelph.ca
Phone: +1 519 824 4120
Fax: +1 519 766 1499
Interests: DNA damage by phenolic toxins including ochratoxin A; Modified DNA bases as fluorescent probes

Guest Editor
Prof. Dr. Annie Pfohl-Leszkowicz
National Agronomical High School of Toulouse (ENSAT), Unit of Toxicology & Food safety, 1 avenue de l’Agrobiopôle, BP 32607, 31326, Auzeville-Tolosane, France
E-Mail: leszkowicz@ensat.fr
Phone: +33 534 323 947
Fax: +33 534 323 947
Interests: mycotoxin; ochratoxin; fumonisin; zearalenone; biomarker; risk evaluation; environmental toxicology; polycyclic aromatic compounds; genotoxicity; DNA adduct; balkan endemic nephropathy; kidney cancer; biotransformation

Special Issue Information

Dear Colleagues,

In the seminal paper published in Nature, 1965, van Der Merwe, Steyn, Fourie, Scott and Theron, reported the isolation of a new toxic metabolite, called ochratoxin A (now abbreviated OTA), from Aspergillus ochraceus. Structural analysis of the mycotoxin pointed to the presence of a chlorophenolic moiety containing a dihydroisocoumarin system amide-linked to L-phenylalanine with toxicity in ducklings of the same order as that of aflatoxin B1 from Aspergillus flavus. Subsequent experimental carcinogenicity studies in male rats and mice carried out in the 1980s demonstrated OTA to be a potent kidney carcinogen and highlighted the real possibility that OTA could be a human carcinogen. OTA causes kidney damage in farm animals and a number of studies also suggested a correlation between OTA exposure and a fatal human kidney disease called Balkan endemic nephropathy, in which patients exhibit a high incidence of urinary tract tumours. OTA is now regarded as the most toxic member of the ochratoxins, which have attracted considerable attention since they are one of the most abundant food-contaminating mycotoxins in the world and are classified as potentially carcinogenic to humans (Group 2B). Ongoing interdisciplinary research on the ochratoxins have been concerned with detection in feed and human foodstuff, occurrence and estimation of dietary intake, establishment of limits for human consumption based on risk assessment and understanding mechanisms of toxicity and carcinogenicity for the development of detoxification processes. We hope that this special issue of Toxins entitled “Ochratoxins” will provide the readership with a better understanding of the key issues being addressed at the present time.

Prof. Dr. Richard A. Manderville
Prof. Dr. Annie Pfohl-Leszkowicz
Guest Editor

Related Special Issues in other Journals

Ochratoxins 2011 in Toxins

Keywords

  • ochratoxins
  • mycotoxin
  • carcinogen
  • Balkan endemic nephropathy
  • DNA damage
  • genotoxic
  • intake
  • biotransformation
  • risk assessment

Published Papers (32 papers)

Toxins 2012, 4(12), 1535-1551; doi:10.3390/toxins4121535
Received: 8 October 2012; in revised form: 27 November 2012 / Accepted: 6 December 2012 / Published: 14 December 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (659 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(11), 2593-2605; doi:10.3390/toxins2112593
Received: 9 September 2010; in revised form: 28 September 2010 / Accepted: 26 October 2010 / Published: 29 October 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (142 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(10), 2337-2339; doi:10.3390/toxins2102337
Received: 17 September 2010; Accepted: 28 September 2010 / Published: 29 September 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (24 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(10), 2333-2336; doi:10.3390/toxins2102333
Received: 2 September 2010; in revised form: 9 September 2010 / Accepted: 21 September 2010 / Published: 29 September 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (144 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(9), 2230-2241; doi:10.3390/toxins2092230
Received: 2 August 2010; in revised form: 13 August 2010 / Accepted: 23 August 2010 / Published: 26 August 2010
Show/Hide Abstract | Cited by 14 | PDF Full-text (394 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(8), 2098-2105; doi:10.3390/toxins2082098
Received: 15 July 2010; in revised form: 3 August 2010 / Accepted: 9 August 2010 / Published: 10 August 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (189 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(8), 1984-1996; doi:10.3390/toxins2081984
Received: 17 June 2010; Accepted: 28 July 2010 / Published: 3 August 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (199 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(7), 1796-1824; doi:10.3390/toxins2071796
Received: 4 June 2010; in revised form: 24 June 2010 / Accepted: 6 July 2010 / Published: 8 July 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (429 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(7), 1718-1750; doi:10.3390/toxins2071718
Received: 6 May 2010; in revised form: 25 June 2010 / Accepted: 29 June 2010 / Published: 1 July 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (418 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1582-1594; doi:10.3390/toxins2061582
Received: 26 March 2010; in revised form: 8 June 2010 / Accepted: 18 June 2010 / Published: 21 June 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (239 KB) | XML Full-text
abstract graphic

Toxins 2010, 2(6), 1536-1553; doi:10.3390/toxins2061536
Received: 2 June 2010; in revised form: 16 June 2010 / Accepted: 17 June 2010 / Published: 18 June 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (188 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1428-1444; doi:10.3390/toxins2061428
Received: 15 April 2010; in revised form: 26 May 2010 / Accepted: 8 June 2010 / Published: 11 June 2010
Show/Hide Abstract | Cited by 18 | PDF Full-text (433 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(6), 1414-1427; doi:10.3390/toxins2061414
Received: 13 May 2010; in revised form: 7 June 2010 / Accepted: 10 June 2010 / Published: 11 June 2010
Show/Hide Abstract | Cited by 4 | PDF Full-text (166 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1381-1398; doi:10.3390/toxins2061381
Received: 15 April 2010; in revised form: 11 May 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
Show/Hide Abstract | Cited by 6 | PDF Full-text (326 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1279-1299; doi:10.3390/toxins2061279
Received: 6 May 2010; in revised form: 28 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (2349 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1265-1278; doi:10.3390/toxins2061265
Received: 22 April 2010; in revised form: 14 May 2010 / Accepted: 31 May 2010 / Published: 1 June 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (273 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(6), 1225-1249; doi:10.3390/toxins2061225
Received: 7 May 2010; in revised form: 17 May 2010 / Accepted: 26 May 2010 / Published: 1 June 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (290 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(5), 1121-1133; doi:10.3390/toxins2051121
Received: 2 April 2010; in revised form: 16 April 2010 / Accepted: 13 May 2010 / Published: 14 May 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (216 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(5), 1111-1120; doi:10.3390/toxins2051111
Received: 16 April 2010; in revised form: 4 May 2010 / Accepted: 11 May 2010 / Published: 14 May 2010
Show/Hide Abstract | Cited by 9 | PDF Full-text (159 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(5), 1100-1110; doi:10.3390/toxins2051100
Received: 9 April 2010; in revised form: 27 April 2010 / Accepted: 11 May 2010 / Published: 13 May 2010
Show/Hide Abstract | Cited by 8 | PDF Full-text (480 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(5), 1078-1099; doi:10.3390/toxins2051078
Received: 1 April 2010; in revised form: 22 April 2010 / Accepted: 12 May 2010 / Published: 13 May 2010
Show/Hide Abstract | Cited by 15 | PDF Full-text (461 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(5), 1065-1077; doi:10.3390/toxins2051065
Received: 1 March 2010; in revised form: 15 March 2010 / Accepted: 12 May 2010 / Published: 13 May 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (223 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(5), 1054-1064; doi:10.3390/toxins2051054
Received: 25 March 2010; in revised form: 14 April 2010 / Accepted: 11 May 2010 / Published: 12 May 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (339 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 840-855; doi:10.3390/toxins2040840
Received: 3 March 2010; in revised form: 14 April 2010 / Accepted: 20 April 2010 / Published: 21 April 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (373 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 809-839; doi:10.3390/toxins204809
Received: 9 March 2010; in revised form: 12 April 2010 / Accepted: 19 April 2010 / Published: 21 April 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (364 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 780-792; doi:10.3390/toxins2040780
Received: 17 March 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (166 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 771-779; doi:10.3390/toxins2040771
Received: 5 March 2010; in revised form: 7 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
Show/Hide Abstract | Cited by 13 | PDF Full-text (266 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 758-770; doi:10.3390/toxins2040758
Received: 26 February 2010; in revised form: 9 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (226 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(4), 649-664; doi:10.3390/toxins2040649
Received: 25 February 2010; in revised form: 28 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
Show/Hide Abstract | Cited by 12 | PDF Full-text (442 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(4), 552-571; doi:10.3390/toxins2040552
Received: 21 February 2010; in revised form: 19 March 2010 / Accepted: 30 March 2010 / Published: 31 March 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (1277 KB) | HTML Full-text | XML Full-text
abstract graphic

Toxins 2010, 2(4), 461-493; doi:10.3390/toxins2040461
Received: 24 January 2010; in revised form: 5 March 2010 / Accepted: 8 March 2010 / Published: 29 March 2010
Show/Hide Abstract | Cited by 32 | PDF Full-text (552 KB) | HTML Full-text | XML Full-text

Toxins 2010, 2(3), 326-340; doi:10.3390/toxins2030326
Received: 21 January 2010; in revised form: 22 February 2010 / Accepted: 24 February 2010 / Published: 9 March 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (2219 KB) | HTML Full-text | XML Full-text

Last update: 5 March 2014

Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert