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Response to Comments of Peter G. Mantle
Departments of Cancer Biology, Urology, and Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC 27157, USA
Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
University of Toulouse, Laboratory Chemical Engineering, Department Bioprocess & Microbial System, UMR CNRS/INPT/UPS 5503, ENSA Toulouse, 1 avenue de l’Agrobiopôle, BP 32607, 31326, Auzeville-Tolosane, France
* Author to whom correspondence should be addressed.
Received: 17 September 2010 / Accepted: 28 September 2010 / Published: 29 September 2010
(This article belongs to the Special Issue Ochratoxins
Abstract: The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.
Keywords: ochratoxin; testicular cancer; DNA adduct
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Cite This Article
MDPI and ACS Style
Schwartz, G.G.; Manderville, R.A.; Pfohl-Leszkowicz, A. Response to Comments of Peter G. Mantle. Toxins 2010, 2, 2337-2339.
Schwartz GG, Manderville RA, Pfohl-Leszkowicz A. Response to Comments of Peter G. Mantle. Toxins. 2010; 2(10):2337-2339.
Schwartz, Gary G.; Manderville, Richard A.; Pfohl-Leszkowicz, Annie. 2010. "Response to Comments of Peter G. Mantle." Toxins 2, no. 10: 2337-2339.