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A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology
Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK
Department of Histopathology, Ealing Hospital, Southall, Middlesex, UB1 3HW, UK
Department of Oral Pathology, Kings College London, London, UK
Pathology Department, County Hospital Timisoara, Romania
Pathology Department, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark
Department of Rheumatology, Aarhus University Hospital, 8000 Aarhus. Denmark
Department of Urology, Ealing Hospital, Southall, Middlesex. UB1 3HW, UK
Department of Biology, University of Medicine and Pharmacy, Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 21 January 2010; in revised form: 22 February 2010 / Accepted: 24 February 2010 / Published: 9 March 2010
(This article belongs to the Special Issue Ochratoxins
Abstract: DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.
Keywords: DNA ploidy; Balkan endemic nephropathy; renal cell carcinoma; ochratoxin A; porcine nephropathy; metastasis; nuclear instability; transitional cell carcinoma; aneuploidisation
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Cite This Article
MDPI and ACS Style
Mantle, P.G.; Amerasinghe, C.; Brown, A.L.; Herman, D.; Horn, T.; Krogh, T.; Odell, E.W.; Rosenbaum, T.; Tatu, C.A. A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology. Toxins 2010, 2, 326-340.
Mantle PG, Amerasinghe C, Brown AL, Herman D, Horn T, Krogh T, Odell EW, Rosenbaum T, Tatu CA. A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology. Toxins. 2010; 2(3):326-340.
Mantle, Peter G.; Amerasinghe, Cyrille; Brown, Amy L.; Herman, Diana; Horn, Thomas; Krogh, Thoger; Odell, Edward W.; Rosenbaum, Tomas; Tatu, Calin A. 2010. "A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology." Toxins 2, no. 3: 326-340.