Toxins 2010, 2(4), 649-664; doi:10.3390/toxins2040649
Article

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

Received: 25 February 2010; in revised form: 28 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Ochratoxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
Keywords: ochratoxin A; phenylalanine; carcinogenic effect; chicks; pathology
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MDPI and ACS Style

Stoev, S.D. Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins 2010, 2, 649-664.

AMA Style

Stoev SD. Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins. 2010; 2(4):649-664.

Chicago/Turabian Style

Stoev, Stoycho D. 2010. "Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks." Toxins 2, no. 4: 649-664.

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