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Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks
Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria
Received: 25 February 2010; in revised form: 28 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Ochratoxins
Abstract: Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
Keywords: ochratoxin A; phenylalanine; carcinogenic effect; chicks; pathology
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MDPI and ACS Style
Stoev, S.D. Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins 2010, 2, 649-664.
Stoev SD. Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins. 2010; 2(4):649-664.
Stoev, Stoycho D. 2010. "Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks." Toxins 2, no. 4: 649-664.