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Toxins 2010, 2(4), 649-664; doi:10.3390/toxins2040649

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria
Received: 25 February 2010 / Revised: 28 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Ochratoxins)
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Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L-β-phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver.
Keywords: ochratoxin A; phenylalanine; carcinogenic effect; chicks; pathology ochratoxin A; phenylalanine; carcinogenic effect; chicks; pathology

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stoev, S.D. Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks. Toxins 2010, 2, 649-664.

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