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Toxins 2010, 2(4), 552-571; doi:10.3390/toxins2040552
Article

Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study

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Received: 21 February 2010; in revised form: 19 March 2010 / Accepted: 30 March 2010 / Published: 31 March 2010
(This article belongs to the collection Ochratoxins)
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Abstract: The potent experimental renal carcinogenesis of ochratoxin A (OTA) in male rats makes the dietary contaminant a potential factor in human oncology. We explored whether the tumour promoter sodium barbitate could shorten the otherwise long latency between exposure to toxin and tumourigenesis. Young rats, of a hybrid in which mononuclear leukaemia was rare, were given feed contaminated (5 ppm) with OTA for 36 weeks to initiate renal tumourigenesis. Some individuals were thereafter given sodium barbitate (500 ppm in drinking water) for life. Pathological outcomes were studied at or near the end of natural life. Renal tumours in males given barbitate became evident after latency of one year, but only slightly before those without barbitate. In contrast, female mammary tumourigenesis was advanced by at least 6 months synchronously in all rats given the OTA-barbitate regimen compared to tumourigenesis in controls. Diagnosis of malignant mammary angiosarcoma in a female given the OTA-barbitate regimen is a new finding in the rat. The long latency of OTA-induced renal tumourigenesis was not notably susceptible to accelerated promotion by barbitate, contrasting with an apparently marked effect of barbitate on development of mammary tumours.
Keywords: DNA ploidy; latency; mononuclear leukaemia; renal tumour; mammary tumour; angiosarcoma DNA ploidy; latency; mononuclear leukaemia; renal tumour; mammary tumour; angiosarcoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mantle, P.G.; Dobrota, M.; Gillett, C.E.; Odell, E.W.; Pinder, S.E. Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study. Toxins 2010, 2, 552-571.

AMA Style

Mantle PG, Dobrota M, Gillett CE, Odell EW, Pinder SE. Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study. Toxins. 2010; 2(4):552-571.

Chicago/Turabian Style

Mantle, Peter G.; Dobrota, Miloslav; Gillett, Cheryl E.; Odell, Edward W.; Pinder, Sarah E. 2010. "Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study." Toxins 2, no. 4: 552-571.



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