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Toxins 2010, 2(6), 1381-1398; doi:10.3390/toxins2061381
Review

Molecular Mechanism of Ochratoxin A Transport in the Kidney

1,* , 1
 and 1,2
Received: 15 April 2010; in revised form: 11 May 2010 / Accepted: 9 June 2010 / Published: 9 June 2010
(This article belongs to the Special Issue Ochratoxins)
View Full-Text   |   Download PDF [326 KB, uploaded 9 June 2010]
Abstract: The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of multispecific organic anion transporters have been identified: organic anion transporters (OATs), organic anion-transporting polypeptides (OATPs), oligopeptide transporters (PEPTs), and ATP-binding cassette (ABC) transporters, such as MRP2 and BCRP. These renal transporters mediate the transmembrane transport of OTA and play a pivotal role in the development of OTA-induced nephrotoxicity.
Keywords: ochratoxin A; mycotoxin; organic anion transporter; kidney; nephrotoxicity ochratoxin A; mycotoxin; organic anion transporter; kidney; nephrotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Anzai, N.; Jutabha, P.; Endou, H. Molecular Mechanism of Ochratoxin A Transport in the Kidney. Toxins 2010, 2, 1381-1398.

AMA Style

Anzai N, Jutabha P, Endou H. Molecular Mechanism of Ochratoxin A Transport in the Kidney. Toxins. 2010; 2(6):1381-1398.

Chicago/Turabian Style

Anzai, Naohiko; Jutabha, Promsuk; Endou, Hitoshi. 2010. "Molecular Mechanism of Ochratoxin A Transport in the Kidney." Toxins 2, no. 6: 1381-1398.


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