Toxins 2010, 2(5), 1054-1064; doi:10.3390/toxins2051054
Article

Occurrence of Ochratoxin A in Southern Spanish Generous Wines under the Denomination of Origin “Jerez-Xérès-Sherry and ‘Manzanilla’ Sanlúcar de Barrameda”

Mª Teresa Murillo-Arbizu 1 email, Susana Amézqueta 2 email, Elena González-Peñas 2,* email and Adela López De Cerain 1 email
1 Department of Nutrition, Food Science, Physiology and Toxicology, School of Pharmacy, University of Navarra, 31008, Pamplona, Spain 2 Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, University of Navarra, 31008 Pamplona, Spain
* Author to whom correspondence should be addressed.
Received: 25 March 2010; in revised form: 14 April 2010 / Accepted: 11 May 2010 / Published: 12 May 2010
(This article belongs to the Special Issue Ochratoxins)
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Abstract: The mycotoxin ochratoxin A (OTA) has toxic effects in animals; the most relevant of them is nephrotoxicity. OTA has also been classified as a possible carcinogen for humans (group 2B) by the International Agency for Research on Cancer (IARC). Therefore, exposure to OTA through contaminated food can represent health impairment to humans. The maximum permitted level for this mycotoxin in wine is 2.0 mg/L. The presence of OTA in Spanish wines produced using the traditional methods under the Denomination of Origin “Jerez-Xérès-Sherry and manzanilla Sanlúcar de Barrameda” was evaluated by a High performance Liquid Chromatography method with fluorescence detection and immunoaffinity column purification. A recovery of 95.4% and a limit of detection and quantification of 0.009 mg/L and 0.02 mg/L respectively, were achieved. In manzanilla, fino, amontillado and oloroso wine, the mean OTA values were 0.042, 0.044, 0.144, and 0.319 mg/L, respectively. These levels are not different from other data given in the reference literature on white wines, although fino and manzanilla wines have very low OTA levels.
Keywords: mycotoxins; ochratoxin A; liquid chromatography; wine; Jerez; Xérès; Sherry; manzanilla

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MDPI and ACS Style

Murillo-Arbizu, M.T.; Amézqueta, S.; González-Peñas, E.; De Cerain, A.L. Occurrence of Ochratoxin A in Southern Spanish Generous Wines under the Denomination of Origin “Jerez-Xérès-Sherry and ‘Manzanilla’ Sanlúcar de Barrameda”. Toxins 2010, 2, 1054-1064.

AMA Style

Murillo-Arbizu MT, Amézqueta S, González-Peñas E, De Cerain AL. Occurrence of Ochratoxin A in Southern Spanish Generous Wines under the Denomination of Origin “Jerez-Xérès-Sherry and ‘Manzanilla’ Sanlúcar de Barrameda”. Toxins. 2010; 2(5):1054-1064.

Chicago/Turabian Style

Murillo-Arbizu, Mª Teresa; Amézqueta, Susana; González-Peñas, Elena; De Cerain, Adela López. 2010. "Occurrence of Ochratoxin A in Southern Spanish Generous Wines under the Denomination of Origin “Jerez-Xérès-Sherry and ‘Manzanilla’ Sanlúcar de Barrameda”." Toxins 2, no. 5: 1054-1064.

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