Toxins 2010, 2(4), 780-792; doi:10.3390/toxins2040780
Article

Ochratoxin A and β2-Microglobulin in BEN Patients and Controls

1email, 2,* email, 1email and 1email
Received: 17 March 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
(This article belongs to the Special Issue Ochratoxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
Keywords: BEN; ochratoxin A; β2-microglobulin
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MDPI and ACS Style

Yordanova, P.; Wilfried, K.; Tsolova, S.; Dimitrov, P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins 2010, 2, 780-792.

AMA Style

Yordanova P, Wilfried K, Tsolova S, Dimitrov P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins. 2010; 2(4):780-792.

Chicago/Turabian Style

Yordanova, Pavlina; Wilfried, Karmaus; Tsolova, Svetla; Dimitrov, Plamen. 2010. "Ochratoxin A and β2-Microglobulin in BEN Patients and Controls." Toxins 2, no. 4: 780-792.

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