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Toxins 2010, 2(4), 780-792; doi:10.3390/toxins2040780
Article

Ochratoxin A and β2-Microglobulin in BEN Patients and Controls

1
,
2,* , 1
 and
1
1 National Center of Public Health Protection, 1431 Sofia, Bulgaria 2 Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA
* Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
(This article belongs to the Special Issue Ochratoxins)
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Abstract

Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
Keywords: BEN; ochratoxin A; β2-microglobulin BEN; ochratoxin A; β2-microglobulin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yordanova, P.; Wilfried, K.; Tsolova, S.; Dimitrov, P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins 2010, 2, 780-792.

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