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Toxins 2010, 2(4), 780-792; doi:10.3390/toxins2040780

Ochratoxin A and β2-Microglobulin in BEN Patients and Controls

National Center of Public Health Protection, 1431 Sofia, Bulgaria
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA
Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
(This article belongs to the Special Issue Ochratoxins)
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Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
Keywords: BEN; ochratoxin A; β2-microglobulin BEN; ochratoxin A; β2-microglobulin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yordanova, P.; Wilfried, K.; Tsolova, S.; Dimitrov, P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins 2010, 2, 780-792.

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