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Ochratoxin A and β2-Microglobulin in BEN Patients and Controls
National Center of Public Health Protection, 1431 Sofia, Bulgaria
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA
* Author to whom correspondence should be addressed.
Received: 17 March 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
(This article belongs to the Special Issue Ochratoxins
Abstract: Ochratoxin A (OTA) is a mycotoxin naturally occurring in different foods. OTA is arguably a risk factor for Balkan endemic nephropathy (BEN). The aims of this study are to (1) test the OTA-BEN association in BEN-groups and controls and (2) determine whether urine β2-microglobulin, a marker of impaired ability of the kidneys to re-absorb, is related to OTA. BEN patients had significantly higher OTA serum levels. Within the offspring, OTA was significantly related to higher β2-microglobulin excretion. OTA (2005/2006) was related to a higher incidence of BEN after 2008, providing further evidence that OTA is a risk factor for BEN.
Keywords: BEN; ochratoxin A; β2-microglobulin
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MDPI and ACS Style
Yordanova, P.; Wilfried, K.; Tsolova, S.; Dimitrov, P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins 2010, 2, 780-792.
Yordanova P, Wilfried K, Tsolova S, Dimitrov P. Ochratoxin A and β2-Microglobulin in BEN Patients and Controls. Toxins. 2010; 2(4):780-792.
Yordanova, Pavlina; Wilfried, Karmaus; Tsolova, Svetla; Dimitrov, Plamen. 2010. "Ochratoxin A and β2-Microglobulin in BEN Patients and Controls." Toxins 2, no. 4: 780-792.