Deadline for manuscript submissions: closed (20 April 2013)
Special Issue Editor
Guest Editor Prof. Dr. Jack A. Schalken
Research Director Urology, Dept. of Urology, University Hospital Nijmegen, Box 9101, Nijmegen NL-6500 HB, The Netherlands
Website: http://www.narcis.nl/person/RecordID/PRS1239673/Language/en Interests: molecular and cellbiology of oncological diseases; cadherine mediated interactions and signal transductions; molecular diagnostics; urogenital oncology; veterinary oncology
Special Issue Information
The unmet needs in prostate cancer diagnosis and therapy are diverse; there is an urgent need for biomarkers that can be used for the early diagnosis of patients with clinically significant prostate cancer. Significant steps forward are made and are reviewed in this issue. Once metastasized, there is still no effective treatment, let stand alone a curative therapy. A better understanding of sustained androgen receptor signaling in CRPC has now led to more effective therapies. Apart from a better insight in the molecular aspects of prostate carcinogenesis and -progression, we need to understand the tumor cell biology. Identification of cancer initiating cells and therapies targeted to eradicate these population(s) are the way forward to combat this disease.
Prof. Dr. Jack A. Schalken Guest Editor
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