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Autophagy in Prostate Cancer and Androgen Suppression Therapy
Institute Pasteur Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics (DAHFMO), Section of Histology & Medical Embryology, Sapienza University of Rome, Rome 00161, Italy
Laboratory of Applied Dermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome 00167, Italy
These authors equally contributed to this work.
* Author to whom correspondence should be addressed.
Received: 17 April 2013; in revised form: 27 May 2013 / Accepted: 31 May 2013 / Published: 6 June 2013
Abstract: The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.
Keywords: autophagy; apoptosis; prostate cancer; androgen deprivation therapy
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MDPI and ACS Style
Ziparo, E.; Petrungaro, S.; Marini, E.S.; Starace, D.; Conti, S.; Facchiano, A.; Filippini, A.; Giampietri, C. Autophagy in Prostate Cancer and Androgen Suppression Therapy. Int. J. Mol. Sci. 2013, 14, 12090-12106.
Ziparo E, Petrungaro S, Marini ES, Starace D, Conti S, Facchiano A, Filippini A, Giampietri C. Autophagy in Prostate Cancer and Androgen Suppression Therapy. International Journal of Molecular Sciences. 2013; 14(6):12090-12106.
Ziparo, Elio; Petrungaro, Simonetta; Marini, Elettra S.; Starace, Donatella; Conti, Silvia; Facchiano, Antonio; Filippini, Antonio; Giampietri, Claudia. 2013. "Autophagy in Prostate Cancer and Androgen Suppression Therapy." Int. J. Mol. Sci. 14, no. 6: 12090-12106.