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Int. J. Mol. Sci. 2013, 14(6), 11816-11829; doi:10.3390/ijms140611816
Article

Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer — Are They Genetically Different?

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Received: 22 April 2013; in revised form: 20 May 2013 / Accepted: 27 May 2013 / Published: 3 June 2013
(This article belongs to the Special Issue Molecular Research in Urology)
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Abstract: Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.
Keywords: prostate cancer; multifocal; unifocal; copy number variation; heterogeneity; affymetrix prostate cancer; multifocal; unifocal; copy number variation; heterogeneity; affymetrix
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ibeawuchi, C.; Schmidt, H.; Voss, R.; Titze, U.; Abbas, M.; Neumann, J.; Eltze, E.; Hoogland, A.M.; Jenster, G.; Brandt, B.; Semjonow, A. Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer — Are They Genetically Different? Int. J. Mol. Sci. 2013, 14, 11816-11829.

AMA Style

Ibeawuchi C, Schmidt H, Voss R, Titze U, Abbas M, Neumann J, Eltze E, Hoogland AM, Jenster G, Brandt B, Semjonow A. Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer — Are They Genetically Different? International Journal of Molecular Sciences. 2013; 14(6):11816-11829.

Chicago/Turabian Style

Ibeawuchi, Chinyere; Schmidt, Hartmut; Voss, Reinhard; Titze, Ulf; Abbas, Mahmoud; Neumann, Joerg; Eltze, Elke; Hoogland, Agnes M.; Jenster, Guido; Brandt, Burkhard; Semjonow, Axel. 2013. "Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer — Are They Genetically Different?" Int. J. Mol. Sci. 14, no. 6: 11816-11829.


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