Next Article in Journal
Genetic Diversity of the Critically Endangered Thuja sutchuenensis Revealed by ISSR Markers and the Implications for Conservation
Next Article in Special Issue
Genetic and Molecular Differences in Prostate Carcinogenesis between African American and Caucasian American Men
Previous Article in Journal / Special Issue
Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy—Focus on Prostate Cancer
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(7), 14833-14859; doi:10.3390/ijms140714833

Posttranslational Modification of the Androgen Receptor in Prostate Cancer

1
Department of Urology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
2
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Received: 5 June 2013 / Revised: 1 July 2013 / Accepted: 3 July 2013 / Published: 16 July 2013
(This article belongs to the Special Issue Molecular Research in Urology)
View Full-Text   |   Download PDF [388 KB, uploaded 19 June 2014]   |  

Abstract

The androgen receptor (AR) is important in the development of the prostate by regulating transcription, cellular proliferation, and apoptosis. AR undergoes posttranslational modifications that alter its transcription activity, translocation to the nucleus and stability. The posttranslational modifications that regulate these events are of utmost importance to understand the functional role of AR and its activity. The majority of these modifications occur in the activation function-1 (AF1) region of the AR, which contains the transcriptional activation unit 1 (TAU1) and 5 (TAU5). Identification of the modifications that occur to these regions may increase our understanding of AR activation in prostate cancer and the role of AR in the progression from androgen-dependent to castration-resistant prostate cancer (CRPC). Most of the posttranslational modifications identified to date have been determined using the full-length AR in androgen dependent cells. Further investigations into the role of posttranslational modifications in androgen-independent activation of full-length AR and constitutively active splicing variants are warranted, findings from which may provide new therapeutic options for CRPC.
Keywords: androgen receptor; castration-resistant prostate cancer; posttranslational modifications androgen receptor; castration-resistant prostate cancer; posttranslational modifications
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Van der Steen, T.; Tindall, D.J.; Huang, H. Posttranslational Modification of the Androgen Receptor in Prostate Cancer. Int. J. Mol. Sci. 2013, 14, 14833-14859.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top