Int. J. Mol. Sci. 2013, 14(5), 10438-10464; doi:10.3390/ijms140510438
Review

Human Prostatic Acid Phosphatase: Structure, Function and Regulation

Received: 15 April 2013; in revised form: 8 May 2013 / Accepted: 8 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Molecular Research in Urology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.
Keywords: prostate cancer; prostatic acid phosphatase; protein tyrosine phosphatase; tumor suppressor; ErbB-2; epigenetic regulation; immunotherapy
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MDPI and ACS Style

Muniyan, S.; Chaturvedi, N.K.; Dwyer, J.G.; LaGrange, C.A.; Chaney, W.G.; Lin, M.-F. Human Prostatic Acid Phosphatase: Structure, Function and Regulation. Int. J. Mol. Sci. 2013, 14, 10438-10464.

AMA Style

Muniyan S, Chaturvedi NK, Dwyer JG, LaGrange CA, Chaney WG, Lin M-F. Human Prostatic Acid Phosphatase: Structure, Function and Regulation. International Journal of Molecular Sciences. 2013; 14(5):10438-10464.

Chicago/Turabian Style

Muniyan, Sakthivel; Chaturvedi, Nagendra K.; Dwyer, Jennifer G.; LaGrange, Chad A.; Chaney, William G.; Lin, Ming-Fong. 2013. "Human Prostatic Acid Phosphatase: Structure, Function and Regulation." Int. J. Mol. Sci. 14, no. 5: 10438-10464.

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