Next Article in Journal
Toll-Like Receptors in Atherosclerosis
Next Article in Special Issue
Lipidosterolic Extract of Serenoa Repens Modulates the Expression of Inflammation Related-Genes in Benign Prostatic Hyperplasia Epithelial and Stromal Cells
Previous Article in Journal / Special Issue
Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(7), 13979-14007; doi:10.3390/ijms140713979

Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication

Laboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, & Radiation Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Received: 17 May 2013 / Revised: 28 June 2013 / Accepted: 1 July 2013 / Published: 4 July 2013
(This article belongs to the Special Issue Molecular Research in Urology)
View Full-Text   |   Download PDF [1518 KB, uploaded 19 June 2014]   |  

Abstract

Activation of Hedgehog (Hh) signaling is implicated in the development and progression of several tumor types, including prostate cancer, which is still the most common non-skin malignancy and the third leading cause of cancer-related mortality in men in industrialized countries worldwide. Several studies have indicated that the Hh pathway plays a crucial role in the development as well as in the progression of this disease to more aggressive and even therapy-resistant disease states. Moreover, preclinical data have shown that inhibition of Hh signaling has the potential to reduce prostate cancer invasiveness and metastatic potential. Clinical trials investigating the benefit of Hh inhibitors in patients with prostate cancer have recently been initiated. However, acquired drug resistance has already been observed in other tumor types after long-term Hh inhibition. Therefore, combining Hh inhibitors with ionizing radiation, chemotherapy or other molecular targeted agents could represent an alternative therapeutic strategy. In this review, we will highlight the role of Hh signaling in the development and progression of prostate cancer and summarize the different therapeutic applications of Hedgehog inhibition. View Full-Text
Keywords: hedgehog pathway; prostate cancer; combination treatment; radiotherapy; chemotherapy; molecular targeted agents hedgehog pathway; prostate cancer; combination treatment; radiotherapy; chemotherapy; molecular targeted agents
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gonnissen, A.; Isebaert, S.; Haustermans, K. Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication. Int. J. Mol. Sci. 2013, 14, 13979-14007.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top