Abstract: A recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele “C” had increased risk for BPH (OR = 1.34, 95% CI: 1.09–1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06–2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results.
Keywords: benign prostatic hyperplasia (BPH); inflammation; LILRA3; single nucleotide polymorphism (SNP); Chinese
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Jiao, Y.; Wang, L.; Gu, X.; Tao, S.; Tian, L.; Na, R.; Chen, Z.; Kang, J.; Zheng, S.L.; Xu, J.; Sun, J.; Qi, J. LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population. Int. J. Mol. Sci. 2013, 14, 8832-8840.
Jiao Y, Wang L, Gu X, Tao S, Tian L, Na R, Chen Z, Kang J, Zheng SL, Xu J, Sun J, Qi J. LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population. International Journal of Molecular Sciences. 2013; 14(5):8832-8840.
Jiao, Yang; Wang, Li; Gu, Xin; Tao, Sha; Tian, Lu; Na, Rong; Chen, Zhuo; Kang, Jian; Zheng, Siqun L.; Xu, Jianfeng; Sun, Jielin; Qi, Jun. 2013. "LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population." Int. J. Mol. Sci. 14, no. 5: 8832-8840.