Next Article in Journal
Bioactive Molecules in Soil Ecosystems: Masters of the Underground
Next Article in Special Issue
D-pinitol Inhibits Prostate Cancer Metastasis through Inhibition of αVβ3 Integrin by Modulating FAK, c-Src and NF-κB Pathways
Previous Article in Journal
Two Distinct Channels Mediated by m2mAChR and α9nAChR Co-Exist in Type II Vestibular Hair Cells of Guinea Pig
Previous Article in Special Issue
Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2013, 14(5), 8832-8840; doi:10.3390/ijms14058832

LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population

1,†
,
2,3,†
,
1
,
2,3
,
2,3
,
2,3
,
2,3
,
1
,
2,3
,
2,3,4
,
2,3
and
1,*
1
Department of Urology, Xinhua Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200092, China
2
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
3
Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
4
Fudan-VARI Center for Genetic Epidemiology, Fudan University, Shanghai 200422, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 February 2013 / Revised: 21 March 2013 / Accepted: 8 April 2013 / Published: 24 April 2013
(This article belongs to the Special Issue Molecular Research in Urology)
View Full-Text   |   Download PDF [200 KB, uploaded 19 June 2014]

Abstract

A recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele “C” had increased risk for BPH (OR = 1.34, 95% CI: 1.09–1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06–2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results.
Keywords: benign prostatic hyperplasia (BPH); inflammation; LILRA3; single nucleotide polymorphism (SNP); Chinese benign prostatic hyperplasia (BPH); inflammation; LILRA3; single nucleotide polymorphism (SNP); Chinese
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jiao, Y.; Wang, L.; Gu, X.; Tao, S.; Tian, L.; Na, R.; Chen, Z.; Kang, J.; Zheng, S.L.; Xu, J.; Sun, J.; Qi, J. LILRA3 Is Associated with Benign Prostatic Hyperplasia Risk in a Chinese Population. Int. J. Mol. Sci. 2013, 14, 8832-8840.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top