Evolving Role of Endoscopy in Adult and Pediatric Gastrointestinal Disorders

Topic Information

Dear Colleagues,

Endoscopy has undergone significant advancements, transforming the diagnosis and management of gastrointestinal (GI) disorders in both adults and children. This Topic explores the evolving role of endoscopic techniques, emphasizing their increasing precision, safety, and therapeutic potential. In adults, endoscopic procedures have shifted from primarily diagnostic tools to minimally invasive therapeutic interventions, such as endoscopic submucosal dissection (ESD) and endoscopic ultrasound (EUS)-guided therapies. These techniques allow for early cancer detection, polyp resection, and the management of complex biliary and pancreatic diseases. Additionally, advancements in artificial intelligence (AI) enhance lesion detection and classification, improving clinical outcomes. Pediatric gastroenterology has also witnessed significant progress, with endoscopy becoming safer and more effective for conditions such as inflammatory bowel disease (IBD), eosinophilic esophagitis, and congenital anomalies. Capsule endoscopy and single-balloon enteroscopy provide less invasive options for small bowel evaluation in children. The future of endoscopy is marked by robot-assisted procedures, AI-driven diagnostics, and the expansion of minimally invasive therapies, further reducing the need for surgery. As technology evolves, the integration of precision medicine and endoscopy will continue to redefine the management of GI disorders across all age groups, offering improved patient care and long-term outcomes.

Dr. Valerio Balassone
Dr. Dominique Schluckebier
Dr. Matteo Tacelli
Prof. Dr. Luigi Dall'Oglio
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Cancers cancers	4.8	9.0	2009	19.1 Days	CHF 2900	Submit
Children children	2.6	4.5	2014	17.5 Days	CHF 2400	Submit
Diagnostics diagnostics	3.8	6.9	2011	21.6 Days	CHF 2600	Submit
Gastrointestinal Disorders gastrointestdisord	1.9	2.1	2019	22.2 Days	CHF 1400	Submit
Journal of Clinical Medicine jcm	3.3	5.2	2012	18.5 Days	CHF 2600	Submit

Preprints.org is a multidisciplinary platform offering a preprint service designed to facilitate the early sharing of your research. It supports and empowers your research journey from the very beginning.

MDPI Topics is collaborating with Preprints.org and has established a direct connection between MDPI journals and the platform. Authors are encouraged to take advantage of this opportunity by posting their preprints at Preprints.org prior to publication:

1. Share your research immediately: disseminate your ideas prior to publication and establish priority for your work.
2. Safeguard your intellectual contribution: Protect your ideas with a time-stamped preprint that serves as proof of your research timeline.
3. Boost visibility and impact: Increase the reach and influence of your research by making it accessible to a global audience.
4. Gain early feedback: Receive valuable input and insights from peers before submitting to a journal.
5. Ensure broad indexing: Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (2 papers)

Order results

Content type Publication Date

Result details

Normal Extended Compact

Journals

All Cancers Diagnostics Gastrointestinal Disorders JCM Children

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

Error

Oops... you haven't selected anything for export.

Ok

clear

9 pages, 261 KB  

Open AccessArticle

A Real-Life Evaluation of the Best Bowel Preparation Regimen Identified in the PrepRICE Trial for Capsule Endoscopies

by Catarina Costa, Maria Manuela Estevinho, Pedro Mesquita, Rita Ferreira, Pedro Vilela Teixeira, João Santos, Ana Ponte and Rolando Pinho

Gastrointest. Disord. 2026, 8(2), 17; https://doi.org/10.3390/gidisord8020017 - 14 Apr 2026

Viewed by 705

Abstract

Background: The optimal bowel preparation regimen for a small bowel capsule endoscopy (SBCE) remains uncertain. The PrepRICE clinical trial showed that the administration of purgatives after the capsule reached the duodenum improved the mucosal visualization and diagnostic yield. However, it was limited [...] Read more.

Background: The optimal bowel preparation regimen for a small bowel capsule endoscopy (SBCE) remains uncertain. The PrepRICE clinical trial showed that the administration of purgatives after the capsule reached the duodenum improved the mucosal visualization and diagnostic yield. However, it was limited to patients with suspected mid-gastrointestinal bleeding who met strict inclusion criteria. This work aims to report real-life results after the implementation of the new protocol and to compare them with those of the PrepRICE trial. Methods: A prospective analysis was performed on all consecutive patients who underwent an SBCE between December of 2024 and December of 2025. The quality of the small bowel visualization (QSBV), gastric transit time (GTT), small bowel transit time (SBTT), adequate visualization rate, and complete examination rate were assessed. The QSBV was evaluated according to the Brotz quantitative scale. Results: A total of 188 patients were included (52.1% male; median age 56 years [IQR 30]). The median Brotz scale scores were 9 (IQR 1), 9 (IQR 1), 8 (IQR 2), and 8 (IQR 1) in the first, second, and third terciles and overall, respectively (compared to 9, 9, 9, 9 in PrepRICE, p < 0.001). No significant differences were found in the complete examination rate (96.8% vs. 99%, p = 0.43), adequate visualization rate (91.3% vs. 92.0%, p = 0.68), GTT and SBTT. Conclusions: The real-life results were good and similar to those of the original study, with a high rate of complete examination and adequate visualization, with slightly weaker QSBV compared to that reported in the periprocedural group in the PrepRICE study yet still superior to the preprocedural groups. Full article

(This article belongs to the Topic Evolving Role of Endoscopy in Adult and Pediatric Gastrointestinal Disorders)

9 pages, 889 KB  

Open AccessArticle

Pancreatitis Preceding the Diagnosis of IBD in Children: A Retrospective Observational Study

by Lorenzo D’Antonio, Valerio Balassone, Federico Alghisi, Chiara Imondi, Francesca Rea, Erminia Romeo, Giulia Angelino, Sabrina Cardile, Daniela Knafelz, Fiammetta Bracci, Paola De Angelis and Simona Faraci

Children 2025, 12(9), 1138; https://doi.org/10.3390/children12091138 - 28 Aug 2025

Viewed by 1588

Abstract

Background: Pancreatic involvement in inflammatory bowel diseases (IBD) is relatively common and includes a range of conditions, such as acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP), and pancreatic exocrine insufficiency (PEI). However, pancreatitis as a precursor to IBD is not [...] Read more.

Background: Pancreatic involvement in inflammatory bowel diseases (IBD) is relatively common and includes a range of conditions, such as acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP), and pancreatic exocrine insufficiency (PEI). However, pancreatitis as a precursor to IBD is not well understood and is rarely reported. Objectives: This study investigates the occurrence, etiology, severity, and recurrence patterns of acute pancreatitis (AP) prior to IBD diagnosis in pediatric patients, with the aim of improving early recognition and diagnostic approaches. Methods: This retrospective observational study was conducted between January 2019 and December 2023 at a tertiary pediatric center, including patients who developed pancreatitis prior to an IBD diagnosis. Demographic information, clinical presentation, laboratory findings, imaging results, fecal calprotectin levels, radiological tests, blood tests, and endoscopic findings were collected. Results: Among 312 pediatric IBD patients (99 with Crohn’s disease (CD), 162 with ulcerative colitis (UC), 7 unclassified, and 44 with very early-onset IBD [VEO-IBD]), 11 (3.5%) had pancreatitis preceding the IBD diagnosis. All the patients showed elevated fecal calprotectin levels, and endoscopy confirmed IBD (four with CD, seven with UC). The median time from the onset of pancreatitis to the IBD diagnosis was 77 weeks (range 0–366 weeks). Conclusions: This study supports the hypothesis that pancreatitis may precede the diagnosis of IBD in some cases, acting as an early extraintestinal manifestation, as previously reported in adults. IBD should be considered in the differential diagnosis of pediatric pancreatitis, particularly in idiopathic cases. Fecal calprotectin testing should be included in the diagnostic workup for pediatric pancreatitis at both initial presentation and during follow-up. Further research is needed to better understand the mechanisms underlying this extraintestinal manifestation. Full article

(This article belongs to the Topic Evolving Role of Endoscopy in Adult and Pediatric Gastrointestinal Disorders)

►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

 

Error

Oops... you haven't selected anything for export.

Ok

clear

Displaying articles 1-2