Skeletal Muscle Adaptations to Oxidative Stress

Topic Information

Dear Colleagues,

Intensive exercise may induce excessive stretching that cause ruptures of myofibril filaments, leading to a skeletal muscle loss of function through the failure of the excitation–contraction coupling system. These events generate an inflammatory response and a higher reactive oxygen species (ROS) production, thus compromising muscle function. ROS are continuously generated in the body and are usually promptly inactivated by cellular antioxidant defenses. In skeletal muscle, low concentrations of ROS modulate cell signaling processes and are required for normal force production. Conversely, higher ROS concentrations can lead to DNA, lipid, protein, and carbohydrate modifications, causing cellular function impairment and a reduced force production, thereby contributing to muscle fatigue. For these reasons, an assessment of the impact of exercise at both the molecular and the biochemical levels, as well as its effect on cellular signaling pathways, constitutes a crucial point of interest for the development of training protocols that are compatible with the health of individuals. This multidisciplinary topic, entitled “Skeletal Muscle Adaptations to Oxidative Stress”, invites researchers in this field to contribute by submitting original research or reviews, with an emphasis on describing new biomarkers or novel exercise-regulated signaling pathways, as well as new techniques and research approaches involved in the interplay between oxidative stress, physical activity, nutritional strategies, and skeletal muscle damage. The main focus of this topic is on human studies, but work with animal models will also be considered. Topics will include (but are not limited to) the following:

• Exercise protocols for health.
• Active life and sedentary lifestyle: the contribution of physical exercise.
• Aging and chronic diseases: exercise as medicine.
• Control of oxidative stress in exercise protocols.
• Physical activity and health of muscle tissue. 

Dr. Guglielmo Duranti
Prof. Dr. Zsolt Radak
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	6.6	12.4	2012	16.9 Days	CHF 2900	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	16.8 Days	CHF 2900	Submit
Journal of Functional Morphology and Kinesiology jfmk	2.5	3.7	2016	19.7 Days	CHF 1600	Submit
Life life	3.4	6.0	2011	17.8 Days	CHF 2600	Submit
Physiologia physiologia	2.3	-	2021	19.6 Days	CHF 1000	Submit

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