Phage Applications from Diagnostics to Treatment of Bacterial Infections in a One Health World

Dear Colleagues,

In recent years, the rise in antibiotic resistance has emerged as a critical global health threat, necessitating innovative approaches to combat infectious diseases. Phage therapy, the therapeutic use of bacteriophages to target and eradicate bacterial pathogens, presents a promising avenue in this battle. This Topic deals with the multifaceted realm of phage therapy within the framework of One Health—a holistic approach that recognizes the interconnectedness of human, animal, and environmental health. Through a comprehensive exploration of phage therapy’s role in a One Health world, this Topic aims to inspire innovative strategies for combating infectious diseases and safeguarding public health in an era of escalating antibiotic resistance. Exploring the intersection of microbiology, medicine, veterinary science, agriculture, and biotechnology, this Topic will collect articles showing the potential of phage therapy to revolutionize bacterial infection/colonization management across diverse ecosystems. From elucidating phage–host interactions to phage molecular characterizations and addressing regulatory challenges, the contributions are expected to investigate the key aspects of phage therapy research and application. In particular, this Topic will explore, but is not limited to, the following applications of phages: (i) therapy in human and veterinary medicine; (ii) hospital sanitization; (iii) treatment and prophylaxis in agriculture and aquaculture; (iv) wastewater plant treatment; and (v) food preservation.

Dr. Mariagrazia Di Luca
Dr. Goran Vukotic
Topic Editors