New Nanomaterials for Biomedical Applications

Topic Information

Dear Colleagues,

In recent years, nanomaterials have gained much interest in the biomedical field, namely in drug delivery, tissue engineering, phototherapy, magnetic hyperthermia therapy, immunotherapy, and antimicrobial therapy, among others. There is now a broad field of research on developing new nanomaterials specifically designed for the previously mentioned bio-applications. Features such as particle morphology (size, thickness, shape) and physicochemical properties play a crucial role in their biological effect and can be tuned to achieve the desired therapeutic outcomes. Surface chemistry and modifications, loading with drugs, or targeting molecules are often performed to maximize treatment efficacy and selectivity. In recent years, new nanomaterials have been introduced, such as graphene-based materials and other two-dimensional nanomaterials, which promise to revolutionize the field of nanomedicine. Nanomaterials produced by self-assembly also present high versatility and almost an illimited range of combinations and structures that can be explored.

This Topic invites original papers and reviews on the recent progress in the following areas:

• Nanomaterials for biomedical applications, such as 2D nanomaterials; metallic-, polymeric-, and lipid-based nanoparticles; metallic-organic frameworks; and self-assembled nanoparticles.
• Surface modification of nanomaterials, such as adsorption or chemical functionalization, to allow for the adjustment of the surface chemistry or for the loading of drugs. This includes functionalization with targeting molecules, antibodies, and/or immunotherapy agents.
• Development of photo-responsive nanomaterials (for cancer phototherapy or antibacterial action) comprising an optimization of the properties and an understanding of the mechanisms that dictate their photothermal and/or photodynamic properties.
• Study of drug loading and release from the surfaces of nanomaterials, their optimization, and biological effects.
• New magnetic hyperthermia therapy agents (based on nanomaterials) with improved magnetic properties, stability in physiological media, biocompatibility, and therapeutic effects.
• Study of nanomaterial-mediated immunomodulation to achieve an immunostimulatory effect (e.g., cancer therapy) or an immunosuppressive effect (e.g., autoimmune diseases).
• Use of nanomaterials for tissue regeneration, cancer therapy, antibacterial effects, etc.—including the production of scaffolds and 3D-printed structures, among others—as well as for related applications as free-standing biomaterials (such as scaffolds, foams, films, etc.).

Articles combining different types of the above-mentioned therapies are highly welcome since this is still an unexplored subject in the field.

Dr. Artur M. Pinto
Dr. Fernão D. Magalhães
Dr. Jean Anne C. Incorvia
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Bioengineering bioengineering	3.8	4.0	2014	16.4 Days	CHF 2700
International Journal of Molecular Sciences ijms	4.9	8.1	2000	16.8 Days	CHF 2900
Nanomaterials nanomaterials	4.4	8.5	2010	14.1 Days	CHF 2400
Pharmaceutics pharmaceutics	4.9	7.9	2009	15.5 Days	CHF 2900
Scientia Pharmaceutica scipharm	2.3	4.6	1930	26.1 Days	CHF 1000

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Published Papers (3 papers)

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All Bioengineering IJMS Nanomaterials Pharmaceutics Sci. Pharm.

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37 pages, 11046 KiB  

Open AccessReview

Magnetic Nanoparticles and Drug Delivery Systems for Anti-Cancer Applications: A Review

by Willem Graham, McKayla Torbett-Dougherty, Akm Islam, Shokoufeh Soleimani, Tracy Ann Bruce-Tagoe and Jacqueline Ann Johnson

Nanomaterials 2025, 15(4), 285; https://doi.org/10.3390/nano15040285 - 13 Feb 2025

Viewed by 2288

Abstract

Cancer continues to be a prominent fatal health issue worldwide, driving the urgent need for more effective treatment strategies. The pressing demand has sparked significant interest in the development of advanced drug delivery systems for chemotherapeutics. The advent of nanotechnology offers a groundbreaking [...] Read more.

Cancer continues to be a prominent fatal health issue worldwide, driving the urgent need for more effective treatment strategies. The pressing demand has sparked significant interest in the development of advanced drug delivery systems for chemotherapeutics. The advent of nanotechnology offers a groundbreaking approach, presenting a promising pathway to revolutionize cancer treatment and improve patient outcomes. Nanomedicine-based drug delivery systems have demonstrated the capability of improving the pharmacokinetic properties and accumulation of chemotherapeutic agents in cancer sites while minimizing the adverse side effects. Despite these advantages, most NDDSs exhibit only limited improvement in cancer treatment during clinical trials. The recent development of magnetic nanoparticles (MNPs) for biomedical applications has revealed a potential opportunity to further enhance the performance of NDDSs. The magnetic properties of MNPs can be utilized to increase the targeting capabilities of NDDSs, improve the controlled release of chemotherapeutic agents, and weaken the chemoresistance of tumors with magnetic hyperthermia. In this review, we will explore recent advancements in research for NDDSs for oncology applications, how MNPs and their properties can augment the capabilities of NDDSs when complexed with them and emphasize the challenges and safety concerns of incorporating these systems into cancer treatment. Full article

(This article belongs to the Topic New Nanomaterials for Biomedical Applications)

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31 pages, 5629 KiB  

Open AccessReview

CAR T Cell Nanosymbionts: Revealing the Boundless Potential of a New Dyad

by Juan C. Baena, Lucy M. Pérez, Alejandro Toro-Pedroza, Toshio Kitawaki and Alexandre Loukanov

Int. J. Mol. Sci. 2024, 25(23), 13157; https://doi.org/10.3390/ijms252313157 - 7 Dec 2024

Viewed by 1656

Abstract

Cancer treatment has traditionally focused on eliminating tumor cells but faces challenges such as resistance and toxicity. A promising direction involves targeting the tumor microenvironment using CAR T cell immunotherapy, which has shown potential for treating relapsed and refractory cancers but is limited [...] Read more.

Cancer treatment has traditionally focused on eliminating tumor cells but faces challenges such as resistance and toxicity. A promising direction involves targeting the tumor microenvironment using CAR T cell immunotherapy, which has shown potential for treating relapsed and refractory cancers but is limited by high costs, resistance, and toxicity, especially in solid tumors. The integration of nanotechnology into ICAM cell therapy, a concept we have named “CAR T nanosymbiosis”, offers new opportunities to overcome these challenges. Nanomaterials can enhance CAR T cell delivery, manufacturing, activity modulation, and targeting of the tumor microenvironment, providing better control and precision. This approach aims to improve the efficacy of CAR T cells against solid tumors, reduce associated toxicities, and ultimately enhance patient outcomes. Several studies have shown promising results, and developing this therapy further is essential for increasing its accessibility and effectiveness. Our “addition by subtraction model” synthesizes these multifaceted elements into a unified strategy to advance cancer treatment paradigms. Full article

(This article belongs to the Topic New Nanomaterials for Biomedical Applications)

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24 pages, 18565 KiB  

Open AccessArticle

Injectable Photocrosslinked Hydrogel Dressing Encapsulating Quercetin-Loaded Zeolitic Imidazolate Framework-8 for Skin Wound Healing

by Zhao Chen, Man Zhe, Wenting Wu, Peiyun Yu, Yuzhen Xiao, Hao Liu, Ming Liu, Zhou Xiang and Fei Xing

Pharmaceutics 2024, 16(11), 1429; https://doi.org/10.3390/pharmaceutics16111429 - 10 Nov 2024

Viewed by 1622

Abstract

Background: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection. Methods: In this research, [...] Read more.

Background: Wound management is a critical component of clinical practice. Promoting timely healing of wounds is essential for patient recovery. Traditional treatments have limited efficacy due to prolonged healing times, excessive inflammatory responses, and susceptibility to infection. Methods: In this research, we created an injectable hydrogel wound dressing formulated from gelatin methacryloyl (GelMA) that encapsulates quercetin-loaded zeolitic imidazolate framework-8 (Qu@ZIF-8) nanoparticles. Next, its ability to promote skin wound healing was validated through in vitro experiments and animal studies. Results: Research conducted both in vitro and in vivo indicated that this hydrogel dressing effectively mitigates inflammation, inhibits bacterial growth, and promotes angiogenesis and collagen synthesis, thus facilitating a safe and efficient healing process for wounds. Conclusions: This cutting-edge scaffold system provides a novel strategy for wound repair and demonstrates significant potential for clinical applications. Full article

(This article belongs to the Topic New Nanomaterials for Biomedical Applications)

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