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Advances in Filament Engineering for Biomaterials
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Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Belfast BT15 1AP, UK
Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK
Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
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Advances in Filament Engineering for Biomaterials

Abstract submission deadline
closed (30 April 2024)
Manuscript submission deadline
closed (30 June 2024)
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Topic Information

Dear Colleagues,

We are pleased to invite researchers from the fields of biomaterials, additive manufacturing, and tissue engineering to submit their latest research findings to our journal. This Special Issue focuses on the latest advances in filament engineering, nanomaterials, composites, biomimicry, and material properties, with a particular emphasis on their applications in drug delivery, wound healing, and tissue engineering. We encourage submissions that explore novel approaches to understanding cell–material interactions, as well as investigations into the potential of filament engineering to enhance the performance of biomaterials. The issue aims to provide a comprehensive overview of the current state of the art in the field, and we invite original research, reviews, and perspectives that will contribute to our understanding of these exciting and rapidly evolving fields. Do not miss this opportunity to share your latest findings with the wider research community and help to shape the future of biomaterials and filament research.

Dr. Ming-Wei Chang
Prof. Dr. Zeeshan Ahmad
Prof. Dr. Hui-Min David Wang
Topic Editors

Keywords

  • biomaterials
  • additive manufacturing
  • filament engineering
  • nanomaterials
  • material properties
  • composites
  • cell–material interactions
  • biomimicry
  • tissue engineering
  • drug delivery

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Bioengineering
bioengineering 		3.8 4.0 2014 16.4 Days CHF 2700
Journal of Manufacturing and Materials Processing
jmmp 		3.3 5.1 2017 16.5 Days CHF 1800
Materials
materials 		3.1 5.8 2008 13.9 Days CHF 2600
Micromachines
micromachines 		3.0 5.2 2010 16.2 Days CHF 2100
Polymers
polymers 		4.7 8.0 2009 14.5 Days CHF 2700

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Published Papers (1 paper)

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14 pages, 2770 KiB  
Article
Computational and Experimental Characterization of Aligned Collagen across Varied Crosslinking Degrees
by Shengmao Lin, Nashaita Y. Patrawalla, Yingnan Zhai, Pengfei Dong, Vipuil Kishore and Linxia Gu
Micromachines 2024, 15(7), 851; https://doi.org/10.3390/mi15070851 - 29 Jun 2024
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Abstract
Collagen-based scaffolds have been widely used in tissue engineering. The alignment of collagen fibers and the degree of crosslinking in engineering tissue scaffolds significantly affect cell activity and scaffold stability. Changes in microarchitecture and crosslinking degree also impact the mechanical properties of collagen [...] Read more.
Collagen-based scaffolds have been widely used in tissue engineering. The alignment of collagen fibers and the degree of crosslinking in engineering tissue scaffolds significantly affect cell activity and scaffold stability. Changes in microarchitecture and crosslinking degree also impact the mechanical properties of collagen scaffolds. A clear understanding of the effects of collagen alignment and crosslinking degrees can help properly control these critical parameters for fabricating collagen scaffolds with desired mechanical properties. In this study, combined uniaxial mechanical testing and finite element method (FEM) were used to quantify the effects of fiber alignment and crosslinking degree on the mechanical properties of collagen threads. We have fabricated electrochemically aligned collagen (ELAC) and compared it with randomly distributed collagen at varying crosslinking degrees, which depend on genipin concentrations of 0.1% or 2% for crosslinking durations of 1, 4, and 24 h. Our results indicate that aligned collagen fibers and higher crosslinking degree contribute to a larger Young’s modulus. Specifically, aligned fiber structure, compared to random collagen, significantly increases Young’s modulus by 112.7% at a 25% crosslinking degree (0.1% (4 h), i.e., 0.1% genipin concentration with a crosslinking duration of 4 h). Moreover, the ELAC Young’s modulus increased by 90.3% as the crosslinking degree doubled by changing the genipin concentration from 0.1% to 2% with the same 4 h crosslinking duration. Furthermore, verified computational models can predict mechanical properties based on specific crosslinking degrees and fiber alignments, which facilitate the controlled fabrication of collagen threads. This combined experimental and computational approach provides a systematic understanding of the interplay among fiber alignment, crosslinking parameters, and mechanical performance of collagen scaffolds. This work will enable the precise fabrication of collagen threads for desired tissue engineering performance, potentially advancing tissue engineering applications. Full article
(This article belongs to the Topic Advances in Filament Engineering for Biomaterials)
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