Targeting Oxidative Stress and Inflammation: Emerging Mechanisms and Therapeutics

A special issue of BioChem (ISSN 2673-6411).

Deadline for manuscript submissions: 31 March 2026 | Viewed by 4131

Special Issue Editors


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Guest Editor
Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693, Maarif, Casablanca 20100, Morocco
Interests: medicinal plants and natural products; free radicals and oxidative stress; animal models; inflammation and inflammatory diseases
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University, Settat 26000, Morocco
Interests: biochemistry and molecular biology; oxidative stress and antioxidants; metabolism; inflammation and inflammatory diseases

E-Mail Website
Guest Editor
Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat, Morocco
Interests: biological properties of medicinal plants and natural products; resistance to anticancer therapies; inflammation and inflammatory diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress and inflammation are intricately linked processes that play pivotal roles in the development and progression of a wide range of chronic diseases, including cardiovascular diseases, neurodegenerative disorders, cancer, diabetes, and autoimmune conditions. The equilibrium between oxidative stress and the body’s antioxidant defense systems, along with the precise regulation of inflammatory pathways, is essential for maintaining physiological homeostasis. The disruption of this delicate balance often results in tissue damage and contributes significantly to the pathogenesis of various diseases.

This Special Issue seeks to consolidate cutting-edge research and comprehensive reviews that delve into the molecular mechanisms bridging oxidative stress and inflammation. We are particularly interested in studies that elucidate their roles in disease pathogenesis and explore innovative therapeutic strategies aimed at mitigating these processes. Submissions are encouraged on topics including the following:

  • Mechanisms of oxidative stress and inflammation;
  • Oxidative stress and inflammation in disease pathogenesis;
  • Therapeutic strategies targeting oxidative stress and inflammation;
  • Role of natural products and phytochemicals;
  • Nanotechnology and drug delivery systems.

We invite researchers to contribute original research articles, comprehensive reviews, and short communications that advance our understanding of the role of oxidative stress and inflammation in cancer. Your work will be instrumental in shaping future research directions and improving therapeutic strategies for cancer patients.

We look forward to your contributions to this critical and rapidly evolving field.

Dr. Hicham Wahnou
Prof. Dr. Riad El Kebbaj
Prof. Dr. Youness Limami
Guest Editors

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Keywords

  • oxidative stress
  • inflammation
  • chronic diseases
  • antioxidants
  • biomarkers
  • therapeutics
  • natural products

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Published Papers (2 papers)

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Review

49 pages, 2570 KB  
Review
Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review
by Charles F. Manful, Eric Fordjour, Emmanuel Ikumoinein, Lord Abbey and Raymond Thomas
BioChem 2025, 5(4), 35; https://doi.org/10.3390/biochem5040035 - 6 Oct 2025
Viewed by 1083
Abstract
Oxidative stress and inflammation are deeply interconnected processes implicated in the onset and progression of numerous chronic diseases. Despite promising mechanistic insights, conventional antioxidant and anti-inflammatory therapies such as NSAIDs, corticosteroids, and dietary antioxidants have shown limited and inconsistent success in long-term clinical [...] Read more.
Oxidative stress and inflammation are deeply interconnected processes implicated in the onset and progression of numerous chronic diseases. Despite promising mechanistic insights, conventional antioxidant and anti-inflammatory therapies such as NSAIDs, corticosteroids, and dietary antioxidants have shown limited and inconsistent success in long-term clinical applications due to challenges with efficacy, safety, and bioavailability. This review explores the molecular interplay between redox imbalance and inflammatory signaling and highlights why conventional therapeutic translation has often been inconsistent. It further examines emerging strategies that aim to overcome these limitations, including mitochondrial-targeted antioxidants, Nrf2 activators, immunometabolic modulators, redox enzyme mimetics, and advanced delivery platforms such as nanoparticle-enabled delivery. Natural polyphenols, nutraceuticals, and regenerative approaches, including stem cell-derived exosomes, are also considered for their dual anti-inflammatory and antioxidant potential. By integrating recent preclinical and clinical evidence, this review underscores the need for multimodal, personalized interventions that target the redox-inflammatory axis more precisely. These advances offer renewed promise for addressing complex diseases rooted in chronic inflammation and oxidative stress. Full article
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21 pages, 2121 KB  
Review
Therapeutic Management of Ebola Virus: Targeting Oxidative Stress and Inflammatory Pathways
by Martin Ndayambaje, Hicham Wahnou, Abdallah Naya and Mounia Oudghiri
BioChem 2025, 5(1), 3; https://doi.org/10.3390/biochem5010003 - 11 Feb 2025
Viewed by 1889
Abstract
The Ebola virus (EBOV), a highly lethal pathogen causing hemorrhagic fever, poses a persistent public health threat, with devastating multi-organ complications and high transmission potential through bodily fluids. EBOV’s pathogenesis is marked by severe oxidative stress and immune dysregulation, where increased reactive oxygen [...] Read more.
The Ebola virus (EBOV), a highly lethal pathogen causing hemorrhagic fever, poses a persistent public health threat, with devastating multi-organ complications and high transmission potential through bodily fluids. EBOV’s pathogenesis is marked by severe oxidative stress and immune dysregulation, where increased reactive oxygen species (ROS) levels foster cellular damage, hinder immune defenses, and facilitate viral replication. Through immune evasion and suppression of cellular stress responses, EBOV affects both innate and adaptive immunity, activating pyroptosis, PANoptosis, necroptosis, and lymphocyte apoptosis, thereby amplifying inflammation and disease severity. Recent research suggests that bioactive molecules, including quercetin, curcumin, eugenol, and p-anisaldehyde, may offer therapeutic potential due to their antioxidant, anti-inflammatory, and immunomodulatory effects. This review also underscores the potential of conventional treatments, including amiodarone, favipiravir, remdesivir, azithromycin, chloroquine, and nitazoxanide, as therapeutic agents against EBOV, thanks to their antiviral and anti-inflammatory properties, although their efficacy varies across experimental models. These natural compounds could enhance immune resilience by scavenging ROS, modulating inflammation, and mitigating immune dysregulation, presenting promising adjunctive strategies to support conventional EBOV therapies. Full article
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