Effects of Ozone on Cardiovascular Diseases

Dear Colleagues,

Ground-level ozone, one of the main air pollutants, is a serious issue and has received increased attention in recent decades. Different from other pollutants, ozone is not directly emitted into the air from specific sources; it is generated by nitrogen oxides (NOx) and volatile organic compounds (VOCs), in the presence of ultraviolet (UV) rays. This means that ozone is a secondary pollutant. The Global Burden of Disease Study 2021 indicates that the risk attributable to DALYs for ambient ozone pollution increased between 2000 and 2021, with the risk value reaching 8·8 (1·9 to 15·0) million in 2021. Ambient ozone mainly enters the human body through inhalation via the respiratory tract, with a smaller portion also being absorbed through the digestive tract and skin. Due to high oxidizing, ozone can cause immune–inflammatory responses that not only damage the respiratory system but also the circulatory system. Recently, more and more studies have shown that exposure to ambient ozone has adverse effects on cardiovascular diseases, including coronary heart disease, arrhythmia, ischemic stroke, and so on. Furthermore, due to the development of new technologies such as multi-omics, the possible mechanisms by which ambient ozone causes diseases are being explored.

For the present Special Issue, we would like to collect original studies, systematic reviews, and short communications on ambient ozone exposure and cardiovascular diseases, including but not limited to ecological studies, case-crossover studies, and cohort studies.

Dr. Jianbing Wang
Guest Editor

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