Search Results (4,923)

This work is axiomatic and structural in nature and is not intended as a phenomenological physical theory, but as a framework clarifying minimal informational primitives from which geometric and dynamical descriptions may emerge. We present a background-independent framework in which physical geometry, interaction-like forces, and spacetime arise as effective descriptions of constrained relational information rather than as fundamental entities. The only primitive structure is a network of degrees of freedom linked by admissible informational relations, each subject to quantifiable constraints on accessibility or flow. The motivation is to identify whether a single minimal relational primitive can account jointly for the emergence of geometry, forces, and spacetime, without presupposing a manifold, fields, or fundamental interactions. The framework is formalized using weighted relational graphs in which constraint weights encode limitations on information flow between degrees of freedom. Effective geometry is defined operationally through minimal constraint cost along relational paths, yielding an emergent metric without assuming spatial embedding. Relational evolution is modeled via a minimal configuration-space dynamics defined by local rewrite moves, and a statistical description is introduced through an informational action that governs coarse-grained response rather than serving as a fundamental dynamical law. Curvature-like observables are defined using transport-based comparisons of local accessibility structure. Within this setting, metric structure emerges from constrained relational accessibility, while curvature-like behavior arises from heterogeneity in constraint structure. Effective forces appear as entropic or informational action gradients with respect to coarse-grained control parameters that modulate relational constraints, and are interpreted as emergent responses rather than primitive interactions. A finite worked example explicitly demonstrates the emergence of nontrivial distance, curvature proxies, and an effective force via geodesic switching under constraint variation, without assuming fundamental spacetime, fields, or particles. The results support an interpretation in which geometry, forces, and spacetime are representational features of constrained information flow rather than fundamental elements of physical law. The framework clarifies conceptual distinctions and points of compatibility with existing approaches to emergent spacetime, and it outlines qualitative expectations for regimes in which smooth geometric descriptions are expected to break down. The work delineates the scope and limits of geometric description without proposing a complete phenomenological theory. Full article

This work provides an in vitro assessment of the antibacterial efficacy of ethanolic extracts derived from four medicinal plants historically utilized in the Aseer region (Foeniculum vulgare, Solanum incanum, Forsskaolea tenacissima, and Abutilon pannosum) against cultured oral bacterial isolates obtained from healthy volunteers. Oral samples from a subset of 50 healthy female participants were included in this analysis, yielding independent cultured bacterial isolates. Isolates were identified using morphological and biochemical characterization combined with partial 16S rRNA gene sequencing and included representatives of common oral-associated genera. Antibacterial activity was assessed using agar disk diffusion and broth microdilution assays. Abutilon pannosum and Solanum incanum had lower values of MIC (range of 16–128 µg/mL), whereas Forsskaolea tenacissima had higher values of MIC (maximum to >512 µg/mL) with the tested isolates. Qualitative microscopic observations and crystal violet biofilm staining showed extract-associated varying cellular morphology, aggregation patterns and surface coverage under sub-inhibitory conditions. Representative isolate scanning electron microscopy (SEM) qualitatively validated descriptive cell surface morphology and organization changes. The research presents preliminary in vitro results of inconsistent antibacterial and antibiofilm effects of crude ethanolic extracts of four plants in the Aseer region on a small (n = 13) group of cultured oral bacteria isolates in healthy volunteers, which requires fractionation and further testing. Full article

Nucleation remains one of the least understood steps during protein crystallization, although it strongly impacts product quality attributes, including total crystal numbers, final crystal size distributions, and thus downstream processing. In this work, the nucleation behavior of Lactobacillus brevis alcohol dehydrogenase (LbADH) wild type (WT) and five mutants (Q207D, Q126H, K32A, D54F, and T102E) is investigated in a stirred 7 mL crystallizer monitored by in situ multi-angle dynamic light scattering (MADLS). Nucleation was studied with highly pure homotetrameric LbADHs by establishing a crystallization, lyophilization, and re-solubilization protocol combined with size exclusion chromatography (SEC) and size exclusion high-performance liquid chromatography (SE-HPLC), yielding tetramer purities above 94% and removing low molecular weight impurities. During stirred batch crystallizations initiated by the addition of polyethyleneglycol 550 monomethyl ether (PEG 550 MME), SEC and SE-HPLC revealed decreasing tetramer peak areas but essentially constant peak apex positions, indicating that no long-lasting oligomeric intermediates accumulate at detectable levels. Time-resolved MADLS measurements using a custom-made flow-through cuvette in a bypass to the stirred crystallizer uncovered transient cluster populations. All protein variants exhibited an initial tetramer peak, followed by the formation of larger aggregates and a rapid rise in signal above a hydrodynamic diameter of 1000 nm, coinciding with the onset of macroscopic turbidity. A simple mesoscale nucleation model was formulated, yielding end-of-nucleation times, crystallized fractions, critical soluble concentrations, and apparent nucleation rate constants. The crystal contact mutations modulate both the timing and magnitude of the nucleation burst (rapid build-up of nuclei/cluster populations). The mutant Q207D showed strongly attenuated nucleation compared to the WT, whereas the other mutants (K32A, D54F, and particularly T102E) display markedly accelerated nucleation at nearly invariant critical concentrations. The combined workflow demonstrates how in situ MADLS, together with a tailored kinetic description, can provide mechanistic insight into protein nucleation in stirred batch crystallizers. Full article

Betaines are natural nitrogen-containing compounds widely distributed in plant-derived foods and animal tissues, where they function primarily as osmolytes, chaperons, and methyl donors. As such, they have attracted increasing interest as dietary components and metabolic biomarkers in human nutrition. This study provides a comparative characterization of glycine betaine (GlyBet) and proline betaine (ProBet) by combining targeted LC–MS quantification in a representative selection of plant-based foods with complementary in silico analyses and integration of dietary intake estimates derived from published nutritional and metabolomic studies, together with human metabolomic data. A validated HPLC–ESI–MS method was applied to quantify GlyBet and ProBet across cereals, pseudocereals, vegetables, and fruits. GlyBet was found to be predominantly abundant in leafy vegetables and in several cereal and pseudocereal flours, whereas ProBet was highly enriched in citrus fruits, particularly bergamot, chinotto, and bitter orange. In silico ADMET predictions were used to provide a qualitative and comparative description of the pharmacokinetic and safety-related properties of the two betaines, indicating broadly similar hydrophilic profiles with modest differences in solubility, clearance, and predicted skin sensitization. Similarity-based target prediction analyses, used in an exploratory framework, suggest distinct contextual tendencies for the two betaines. GlyBet is primarily associated with pathways related to one-carbon metabolism and cellular stress responses, whereas ProBet shows a closer contextual association with signaling-related processes. By integrating experimental data, computational analyses, and human metabolomic information, this work supports the interpretation of betaines as biomarkers of dietary intake and systemic metabolic status. Full article

In this research, the alignment and mapping between Modular Object-Oriented Dynamic Learning Environment (Moodle) learning resources and course topics are described using text similarity methods. The goal of this work is to improve the accuracy of automated alignment between Moodle course learning resources and course topics by analyzing text similarity method performance and examining factors that affect how closely they match expert evaluation. During this research, an expert first mapped the e-course learning resources to course topics, after which multiple text similarity techniques were applied to match resource titles and descriptions to those topics. The findings show that the Large Language Model (LLM)-based solution achieves the lowest mean absolute error (MAE), the lowest mean squared error (MSE), and the strongest agreement with expert evaluation. Traditional keyword-based methods, such as Jaccard similarity and Term Frequency–Inverse Document Frequency (TF-IDF), demonstrate moderate performance, while the Sentence Bidirectional Encoder Representations from Transformers (SBERT)-based model shows the weakest alignment with expert evaluation. Full article

Background/Objectives: The aim of this study was to determine the relationship between self-efficacy and caregiving competence in family caregivers of patients with chronic kidney disease receiving renal replacement therapy. Methods: This was a quantitative, observational, descriptive, and correlational study, in which a sample of 275 caregivers was obtained through non-probabilistic convenience sampling. Information on the participants was collected using a sociodemographic characterization form, the Revised Caregiver Self-Efficacy Scale, and the Caregiver Competence for Care instrument, short version. Results: Most of the caregivers, with a median age of 50, were women, homemakers, cohabiting in a common-law relationship, with complete or incomplete high school education, in socioeconomic stratum 1, from urban areas, affiliated with the subsidized healthcare system, Catholic, wives of the person they care for, and receiving family support. A high linear correlation (Spearman’s Rho = 0.771) was found, which was statistically significant (p < 0.01): the greater the self-efficacy (confidence of the caregiver in performing their work), the greater the competence in caregiving. Conclusions: A positive and significant correlation between self-efficacy and caregiving competence was identified among the participating caregivers. Likewise, variables such as age, length of time as a caregiver, and number of hours per day devoted to caregiving were associated with higher levels of caregiving competence. Full article

Background/Objectives: This study aims to assess the prevalence and predictors of burnout among urology professionals in Pakistan using a validated tool and to explore underlying causes through qualitative input. Methods: A cross-sectional survey was conducted among urology trainees, fellows, and consultants across Pakistan. Burnout was measured using the Maslach Burnout Inventory–Human Services Survey (MBI-HSS). Burnout was defined using a criterion of high emotional exhaustion or high depersonalization. Descriptive statistics and chi-square tests were used to assess associations. Thematic analysis was applied to open-ended responses. Results: A total of 183 responses were received. When using the high emotional exhaustion (EE) or depersonalization (DP) criterion, 62% was classified as experiencing burnout. Significant predictors included excessive working hours (more than 80 h per week), frequent night calls, avoidance-based coping, workplace favouritism, and discrimination. No association was found with gender, age, or designation. Thematic responses highlighted five common causes of burnout. Conclusions: Burnout is prevalent among urology professionals in Pakistan and is largely driven by modifiable factors. Interventions must target institutional support, work–life balance, and healthier coping mechanisms. Full article

Background: Missed nursing care, defined as essential patient care that is omitted or delayed, is a growing source of concern due to its effects on healthcare quality and patient safety. Our aims in this study were twofold: first, we examined the extent and types of missed nursing care, and second, we analyzed the relationship between the care missed by hospital nurses and the staffing and resource adequacy in an academic medical center. Methods: A descriptive cross-sectional study was conducted during the period between November 2022 and July 2023. Data were collected using a self-administered questionnaire that comprised items on socio-demographic and work-related characteristics, items on staffing and resource availability, and items from the ‘MISSCARE’ Survey. Results: The most frequently missed nursing care involved pressure-relieving interventions (Mean = 2.39) and ambulation/mobilization (Mean = 2.27), while medication administration (Mean = 1.60) and glucose monitoring (Mean = 1.56) were missed the least. Labor resource inadequacy (β = 0.315, p < 0.001) and communication and teamwork deficits (β = 0.285, p < 0.001) were positively associated with missed nursing care, whereas staffing and resource adequacy showed an inverse association (β = −0.164, p = 0.006). The model explained 49.8% of the variance in missed nursing care (R² = 0.498). Conclusions: These findings highlight that missed nursing care is a system-level issue primarily associated with staffing and resource constraints rather than individual characteristics. Improving staffing adequacy, resource availability, and interprofessional collaboration may reduce care omissions and enhance patient safety in Saudi Arabian academic medical centers. Full article

This work presents the development and validation of a 1D finite-volume model for the simulation of planar solid oxide cells (SOCs), developed for integration in more complex systems and process simulations. The model allows to investigate the temperature, composition, and current density profiles along the channel. In this work, the Fick’s equations typically used to calculate the concentration overpotential due to H₂ and H₂O diffusion in the electrode are improved compared to 1D SOC models available in the literature. In particular, the approximate analytical solution of the dusty gas model (DGM) equations allows for a better definition of H₂ and H₂O mixture diffusion coefficients, which are relevant, for instance, in the case of solid oxide fuel cells (SOFCs) fed with reformate gas mixtures. Differently from other 1D models available in the literature, the model developed is validated using experimental SOFC polarization curves covering a wide range of operating conditions in terms of molar fraction of H₂ (21–93%) and H₂O (7–50%) in the fuel, temperature (550–750 °C), and fuel utilization factor (exceeding 90%), demonstrating that 1D SOC models retain a good description of the physical processes occurring within the cell. While this work focuses on a co-flow SOFC configuration, the model can simulate a counter-flow configuration and electrolysis operation without modifying the model equations. Full article

Reliable multivariable control is critical for industrial sectors where processes exhibit severe nonlinearities and interactions. A Continuous Stirred Tank Reactor (CSTR) is a rigorous benchmark for testing control strategies addressing these complexities. This work first establishes a linear MIMO mathematical framework to define the specific structure of such interactive systems. Analysis via phase planes and steady-state analysis reveals low controllability, bistability, and strong coupling, leading to the collapse of traditional decoupled control schemes. To address these issues via multivariable control, we propose a centralized MIMO RST control structure synthesized via a Matrix Fraction Description (MFD) and the extended Bézout equation. Simulations for performance evaluation and comparison highlight the following key findings: (1) the centralized RST maintains stability and tracking precision in regions where decentralized RST loops fail; (2) it exhibits performance comparable to the Augmented State Pole Placement with Integral Action (ASPPIA) method and outperforms the standard Model-Based Predictive Control (MPC) baseline, particularly during critical equilibrium point transitions; and (3) it offers a robust yet computationally simple design that provides superior flexibility for pole placement, accommodating future identification-based models and adaptive tuning. These results validate our algebraic synthesis as a robust, computationally efficient solution for managing highly interactive nonlinear dynamics. Full article

Biosecurity plays a central role in preventing disease transmission in dairy production systems and animal welfare. However, quantitative data on biosecurity implementation in smallholder and medium-scale dairy farms remains inconsistent, especially in developing countries. This study provides a structured assessment of on-farm biosecurity practices in northern Kosovo using a standardized, risk-based scoring approach. A cross-sectional survey was conducted on 55 dairy farms using the unmodified Biocheck.UGent™ dairy questionnaire. External and internal biosecurity scores were calculated through predefined, weighted algorithms and analyzed using non-parametric descriptive statistics. Farm-level results were subsequently compared with international reference values derived from the Biocheck.UGent™ global database. The median biosecurity scores for Kosovo farms were 47.8% for external biosecurity and 29.0% for internal biosecurity, indicating uneven implementation with pronounced weaknesses in measures designed to limit within-herd transmission. The lowest-scoring domains were purchase and reproduction and feed and water within external biosecurity, and working organization and equipment, calf management, and calving management within internal biosecurity. In contrast, visitors and farmworkers, control of vermin and other animals among external measures, and adult cattle management among internal measures, showed relatively higher scores, although all remained below international reference levels. When compared with the global overall biosecurity reference median of 76.7% derived from the Biocheck.UGent™ database, the biosecurity performance of the surveyed dairy farms in Kosovo was substantially lower. This gap does not indicate a complete absence of biosecurity measures but rather an uneven application, with the most pronounced deficiency observed in routine practices that govern within-herd disease transmission. The use of a risk-based scoring system allowed these weaknesses to be identified in a structured manner and placed the Kosovo results within an international benchmarking framework. In this context, the approach functions as a practical diagnostic tool, enabling farmers and veterinarians to prioritize feasible, epidemiological-relevant improvements within small- and medium-scale dairy production settings. Full article

This article investigates how Job 1–3 may be read as a single narrative–dramatic unit shaped by a ritual process of mourning, with particular attention to the transition from the prose tale (Job 1–2) to the poetic imprecation (Job 3). The enquiry proceeds by means of a comparative analysis of the prologues of the Ugaritic epics Keret (KTU 1.14 I:1–II:5) and Aqhat (KTU 1.17 I:1–47), texts frequently invoked for contextualising Job within Ancient West Asia. In a first stage, close reading of these Ugaritic prologues identifies narrative techniques for signalling ritual practices—especially lament and incubatio—while remaining largely allusive rather than descriptive. In a second stage, the study turns to the canonical form of Job 1–3 and re-examines its scene arrangement, pacing, and speech-acts against that epic model, including the function of framing formulae and temporal markers. The analysis is intentionally confined to the present form of the text. The paper thus offers a controlled methodological work in comparative poetics and ritual analysis, asking how far Ugaritic epic conventions can illuminate continuity across genre and register at the opening of Job. Full article

Background/Objectives: This study aimed to compare the cleaning efficacy, biomechanical stress distribution under simulated occlusal loading after instrumentation, and irrigant dynamics of three NiTi rotary systems, namely ProTaper Gold, TruNatomy, and SlimShaper, using a combined experimental, finite element analysis (FEA), and computational fluid dynamics (CFD) approach. Methods: Transparent 3D replicas of mandibular mesial roots filled with a gel-like pulp tissue were instrumented with the three systems (n = 13 per group). Standardized irrigation was performed with 4% NaOCl delivered through IrriFlex^® needles positioned 2 mm from the working length. Cleaning effectiveness was assessed through digital image analysis, FEA simulation of occlusal loading, and CFD evaluation of irrigation flow, wall shear stress, and dynamic pressure. Results: All systems left residual tissue, with no statistically significant differences in cleaning efficacy among them (p > 0.05). Descriptively, ProTaper Gold showed the lowest mean residual tissue (0.15 ± 0.25%), followed by SlimShaper (2.50 ± 3.81%) and TruNatomy (4.20 ± 5.12%). CFD revealed that ProTaper Gold generated the highest irrigant velocities and wall shear stresses, while SlimShaper showed the highest dynamic pressure. FEA indicated that ProTaper Gold produced the highest stress concentrations, especially in the pericervical dentin, whereas TruNatomy and SlimShaper preserved more dentin. Conclusions: Cleaning efficacy was comparable across systems. CFD/FEA from representative models illustrated patterns of irrigant dynamics and dentin preservation without supporting system superiority. Full article

This study presents Robo-ICARE (Robotics-Inclusive Child-Centered Approach for Robotics in Education), a Child–Robot Interaction (cHRI) framework for designing inclusive educational robotics in under-resourced and multigrade classroom contexts. The framework addresses gaps in existing educational robotics approaches by integrating user-centered design, affective expressiveness, pedagogical alignment and inclusivity, with particular attention to learner variability and contextual constraints. Robo-ICARE comprises six interrelated design dimensions—embodiment, interactivity, intelligence, pedagogical alignment, inclusivity, and user-centered process—intended to guide the design implementation, and evaluation of educational robots in authentic classroom environments. The framework is operationalized and empirically examined through a case study involving COODI, a low-cost and emotionally expressive educational robot co-designed with students and teachers in rural Chile. The study follows a primarily qualitative, exploratory design-based research approach, supported by descriptive quantitative measures. Empirical evaluation with 49 participants focuses on usability, user experience, engagement, and emotional acceptance, rather than on causal measurement of learning gains. The findings indicate that the proposed framework supports the design of emotionally engaging and context-sensitive educational robotics experiences that are feasible in low-resource settings. Overall, this work contributes a design-guiding, empirically grounded framework that bridges child–robot interaction theory and educational practice, offering a replicable approach for inclusive educational robotics in under-resourced classroom contexts. Full article

This paper presents a comprehensive technology-oriented review of aerospace development in Peru, integrating historical scientific infrastructure, suborbital experimentation, orbital satellite missions, and a systematic literature review of contemporary engineering research. Beyond a descriptive historical account, the study evaluates national aerospace capabilities from a system-engineering perspective, emphasizing technology readiness levels (TRL), subsystem integration, and validation environments. A regional comparison based on UNOOSA, CelesTrak, and nanosatellite databases contextualizes Peru’s orbital activity within South America. Furthermore, a systematic literature review using the PRISMA 2020 methodology was performed covering the period 2000–2025. The systematic literature review identifies nine major aerospace research lines, quantifies institutional participation through bibliometric analysis, and assigns TRLs using consistent criteria derived from reported experimental and operational evidence. The results reveal a fragmented yet progressively maturing ecosystem, characterized by strong analytical and laboratory-level capabilities (TRL 2–5) but limited system-level integration and flight-qualified developments (TRLs $N\ge 6$). These findings highlight structural gaps in program continuity, test infrastructure, and transition mechanisms from academic prototyping to operational aerospace systems. Overall, this work establishes a technology assessment baseline for an emerging space nation, providing evidence-based insights relevant to aerospace engineering, technology management, and capacity-building strategies in developing space ecosystems. Full article