Search Results (220)

Background/Objectives: Romania remains a tuberculosis (TB) hotspot in the European Union, yet host-derived factors of poor outcomes are poorly characterised. We quantified circulating pro-inflammatory cytokines and examined their interplay with behavioural risk factors, the nutritional status, and the clinical course in adults hospitalised with pulmonary TB. We analysed 80 adults with microbiologically confirmed pulmonary TB and 40 respiratory symptom controls; four TB patients (5%) died during hospitalisation, all within 10 days of admission. Methods: A retrospective analytical case–control study was conducted at the Constanța regional TB referral centre (October 2020—October 2023). Patients with smear- or culture-confirmed TB were frequency-matched by sex, 10-year age band, and BMI class to culture-negative respiratory controls at a 2:1 ratio. The patients’ serum interferon-γ (IFN-γ), interleukin-1α (IL-1α), interleukin-1β (IL-1β), and tumour-necrosis-factor-α (TNF-α) were quantified within 24 h of admission; the neutrophil/lymphocyte ratio (NLR) was extracted from full blood counts. Independent predictors of in-hospital mortality were identified by multivariable logistic regression; factors associated with the length of stay (LOS) were modelled with quasi-Poisson regression. Results: The median TNF-α (24.1 pg mL⁻¹ vs. 16.2 pg mL⁻¹; p = 0.009) and IL-1β (5.34 pg mL⁻¹ vs. 3.67 pg mL⁻¹; p = 0.008) were significantly higher in the TB cases than in controls. TNF-α was strongly correlated with IL-1β (ρ = 0.80; p < 0.001), while NLR showed weak concordance with multiplex cytokine patterns. Among the patients with TB, four early deaths (5%) exhibited a tripling of TNF-α (71.4 pg mL⁻¹) and a doubling of NLR (7.8) compared with the survivors. Each 10 pg mL⁻¹ rise in TNF-α independently increased the odds of in-hospital death by 1.8-fold (95% CI 1.1–3.0; p = 0.02). The LOS (median 29 days) was unrelated to the smoking, alcohol, or comorbidity load, but varied across BMI strata: underweight, 27 days; normal weight, 30 days; overweight, 23 days (Kruskal–Wallis p = 0.03). In a multivariable analysis, under-nutrition (BMI < 18.5 kg m⁻²) prolonged the LOS by 19% (IRR 1.19; 95% CI 1.05–1.34; p = 0.004) independently of the disease severity. Conclusions: A hyper-TNF-α/IL-1β systemic signature correlates with early mortality in Romanian pulmonary TB, while under-nutrition is the dominant modifiable determinant of prolonged hospitalisation. Admission algorithms that pair rapid TNF-α testing with systematic nutritional assessment could enable targeted host-directed therapy trials and optimise bed utilisation in high-burden settings. Full article

Canine morbillivirus (CDV), the cause of canine distemper, is a pathogen affecting many hosts. While modified live virus (MLV) vaccines are crucial for controlling the disease in dogs, cases of vaccine-related infections have been found in both domestic and wild animals. Specifically, the America-1 and Rockborn-like vaccine genotypes are concerning due to their spread and ability to transmit between different species. This study conducted a review and analysis of molecular detections of these strains in various carnivores (domestic, captive, synanthropic, and wild species). This study used a conceptual model considering host ecology and the domestic–wild interface to evaluate plausible transmission connections over time using Linear Directional Mean (LDM) and Weighted Mean Centre (WMC) methods. Statistical analyses examined the relationship between how likely a strain is to spread and factors like host type and vaccination status. The findings showed that the America-1 genotype spread in a more organised way, with domestic dogs being the main source and recipient, bridging different environments. Synanthropic mesocarnivores also played this same role, with less intensity. America-1 was most concentrated in the North Atlantic and Western Europe. In contrast, the Rockborn-like strain showed a more unpredictable and restricted spread, residual circulation from past use rather than ongoing spread. Species involved in vaccine-related infections often share characteristics like generalist behaviour, social living, and a preference for areas where domestic animals and wildlife interact. We did not find a general link between a host vaccination status and the likelihood of the strain spreading. The study emphasised the ongoing risk of vaccine-derived strains moving from domestic and synanthropic animals to vulnerable wild species, supporting the need for improved vaccination approaches. Mapping these plausible transmission routes can serve as a basis for targeted surveillance, not only of vaccine-derived strains, but of any other circulating genotype. Full article

Extraterrestrial exploration presents unique challenges for robotic systems, as traditional rigid rovers face limitations in stowage volume, traction on unpredictable terrain, and susceptibility to damage. Soft robotics offers promising solutions through bio-inspired designs that can mimic natural locomotion mechanisms. Here, we present an optimised, spider-inspired soft jumping robot for extraterrestrial exploration that addresses key challenges in soft robotics: actuation efficiency, controllability, and deployment. Drawing inspiration from spider physiology—particularly their hydraulic extension mechanism—we develop a lightweight limb capable of multi-modal behaviour with significantly reduced energy requirements. Our 3D-printed soft actuator leverages pressure-driven collapse for efficient retraction and pressure-enhanced rapid extension, achieving a power-to-weight ratio of 249 W/kg. The integration of a non-backdriveable clutch mechanism enables the system to hold positions with zero energy expenditure—a critical feature for space applications. Experimental characterisation and a subsequent optimisation methodology across various materials, dimensions, and pressures reveal that the robot can achieve jumping heights of up to 1.86 times its body length. The collapsible nature of the soft limb enables efficient stowage during spacecraft transit, while the integrated pumping system facilitates self-deployment upon arrival. This work demonstrates how biologically inspired design principles can be effectively applied to develop versatile robotic systems optimised for the unique constraints of extraterrestrial exploration. Full article

Background and Objectives: The associations between body appreciation, weight status, and weight management practices are influenced by societal, cultural, and psychological factors. Studies indicated that a higher level of body appreciation is linked to lower engagement in unhealthy weight management practices. The transition from high school to university is a significant life event, often accompanied by substantial lifestyle changes that can affect students’ body image and weight-related behaviours. This study aimed to assess the associations between body appreciation, weight status, and weight management behaviours among first-year students at four universities of applied sciences in Lithuania. Materials and Methods: A cross-sectional online survey was conducted in 2022 among 709 first-year students (216 males and 493 females) at the four largest universities of applied sciences in Vilnius, Kaunas, Klaipėda, and Šiauliai. Body appreciation was assessed using the Body Appreciation Scale-2 (BAS-2), whilst BMI was calculated from self-reported height and weight. Students were asked about their weight management practices. Logistic regression analysis was applied to evaluate associations between weight management behaviours, body appreciation, and weight status. Results: Female students had a significantly lower median BMI (21.1 kg/m²) than males (23.3 kg/m²) but were more likely to perceive themselves as overweight (34.5% vs. 17.1%), worry about gaining weight (40.6% vs. 11.6%), and attempt weight loss (52.5% vs. 23.6%) (all p < 0.001). Higher BAS scores were associated with greater accuracy in weight perception, higher satisfaction with body weight, and fewer concerns about weight gain. Students with lower BAS scores were more likely to engage in harmful weight-control behaviours such as smoking (OR = 0.07; 95% CI: 0.02–0.25 for high vs. low BAS) and were more strongly influenced by media beauty standards and dissatisfaction with appearance. Conclusions: Body appreciation is linked to healthier weight perceptions and behaviours. Interventions that enhance body appreciation may help reduce body dissatisfaction and prevent unhealthy weight control practices, especially among female students. Full article

Background/Objectives: Food addiction (FA) and binge eating disorder share many overlapping features. Many individuals with binge eating disorder experience stigma; however, less is known about the stigma associated with food addiction. The current study examined the weight-based stigma and mental illness stigma associated with attributing disordered eating behaviours to an FA diagnosis or binge eating disorder diagnosis. Methods: Undergraduate students (N = 177) were randomly assigned to read one of three vignettes (FA, binge eating disorder, or control), all of which described a character experiencing the overlapping features of FA and binge eating disorder; the vignettes differed only regarding the diagnosis to which the eating behaviours were attributed. Participants then completed questionnaires assessing their attitudes towards mental illness and obesity followed by questionnaires assessing their own eating behaviours. Results: There were no significant between-group differences in mental illness stigma or weight-based stigma. Significant differences in stigma were found based on the perceived gender of the vignette character and participants’ own FA and binge eating disorder symptoms. Conclusions: Stigma may not differ based on the diagnosis ascribed to addictive-like eating behaviours. Women may be more stigmatized for addictive-like eating behaviours, and individuals who experience addictive-like eating may be more stigmatizing towards others with these behaviours. Full article

Developing control systems for high aspect ratio aircraft can be challenging due to the flexibility of the structure involved in the control loop design. A model-based approach can be straightforward to tune the control system parameters and, to this aim, a reliable aircraft flexible model is mandatory. This paper aims to present the approach pursued to design a control strategy considering the flexible aircraft simulator in the loop. Once the elastic model for the longitudinal dynamics has been set up, genetic algorithms are used to determine-together with a Linear Quadratic Regulator controller—a logic to improve the dynamic behaviour whilst encountering a gust. A relatively low order elastic model is developed for the dynamics in the longitudinal plane, including both rigid body and elastic degrees of freedom defined in a vehicle-fixed reference frame. The rigid body degrees of freedom and the associated states are the same as those of the rigid vehicle, whilst the additional states represent the elastic degrees of freedom. Modal characteristics are calculated from a finite element model of the aircraft using a commercial code, with the weight distribution added as lumped masses on grid points, while the aerodynamic rigid properties are described with a nonlinear database. Using the 2-D strip theory and neglecting the unsteady effects, the aeroelastic stability derivatives, i.e., elastic influence coefficients, are computed to superimpose the elastic effects on the rigid body degrees of freedom and vice versa. The flexible dynamics is compared to the rigid one in order to highlight the relevant changes in the aircraft modes. Following is herein proposed a control strategy combining genetic algorithms and Linear Quadratic Regulator controller to reduce the load factor, also considering the oscillation amplitude due to a deterministic gust encountered in a predefined flight condition. Full article

Background: Anorexia nervosa is an eating disorder characterised by distorted eating behaviour, physical and mental health problems, and the highest mortality rate among psychiatric disorders. Although anorexia nervosa appears to be associated with alterations in the spine, studies investigating the characteristics of spinal postures and mobility in individuals with anorexia nervosa are scarce to date. The present study aims to examine the relationship between anorexia nervosa and spinal posture and mobility by comparing people with anorexia nervosa to age-matched, normal-weight controls. Methods: Spinal posture and mobility were evaluated using a radiation-free back scan, the Idiag M360 (Idiag, Fehraltorf, Switzerland). Between-group differences were assessed using a two-way analysis of variance. Results: Adult females suffering from anorexia nervosa exhibited reduced lumbar [difference between groups (Δ) = 10.5°, 95% CI 4.6°–16.5°, p < 0.001] and thoracic (Δ = 8.8°, 95% CI 2.4°–15.2°, p = 0.007) curvatures compared to normal-weight controls. The only difference observed in spinal movements between the two groups was thoracic flexion, which was greater in individuals with anorexia nervosa (Δ = 8.4°, 95% CI 2.1°–14.4°, p = 0.009). Conclusions: These findings emphasise the need to consider spinal posture and thoracic mobility in the musculoskeletal assessment of anorexia nervosa. Interventions aimed at improving spinal postures may help to develop effective rehabilitative strategies for addressing spinal problems associated with anorexia nervosa and thus contributing to counteract the possible further worsening with advancing age. Full article

Alfalfa (Medicago sativa) is an important fodder crop with 16–25% protein and 20–30% fibre content. It requires pollinators for seed development through a process known as “tripping”. Honey bees are preferred for their easy management and mass rearing to enhance pollination. In a field experiment, we tested three treatments: two honey bee colonies (moderately supplemented), three honey bee colonies (highly supplemented), and a control with no honey bee colonies. The colonies European honey bee, A. mellifera, were used, starting at the flowering stage. We assessed the abundance, foraging, and tripping behaviour of pollinators, as well as the number of seeds per pod, pod weight, and seed weight. Honey bees were the most abundant in supplemented plots, followed by solitary bees, with increased honey bee visitation in the second year. Megachile cephalotes, M. hera, and A. mellifera were the most efficient pollinators regarding seeds per pod and seed weight. The plot with two honey bee colonies had a higher seed yield than the one with three colonies. Conservation of these pollinators and the introduction of managed A. mellifera colonies can lead to sustainable alfalfa seed production. Our findings suggest that honey bee supplementation, along with conservation efforts for solitary bees, can enhance pollination and seed yield in alfalfa. Full article

Background/Objectives: To inform person-centred clinical practice, it is important to know what features may predict or moderate treatment outcomes. Thus, we investigated pre-treatment clinical features and mid-therapy reduction in loss of control over eating (MTLOCE), including impacts on treatment outcomes of a new manualised psychotherapy, a healthy approach to weight management and food in eating disorders (HAPIFED). HAPIFED was developed as an integrated psychological and behavioural treatment for individuals with bulimia nervosa or binge eating disorder, which are co-morbid with a high body mass index (BMI). Methods: In total, 50 participants were randomised to HAPIFED and 48 were randomised to the control cognitive behaviour therapy-enhanced group. Assessments included mental health-related quality of life (MHRQoL), eating disorder symptom severity, binge-eating frequency, BMI, and loss of control over eating (LOCE) at baseline, mid-treatment, end-treatment, and 6 and 12 months end of follow-up (EndFU). These were measured with the SF-12, the EDE-Q, and the LOCES, respectively. Linear and negative binomial mixed models were used. Missing data were imputed multiple times, assuming intention of treatment for the analysis. Results: Pre-treatment eating disorder symptom severity, MHRQoL, and BMI positively predicted eating disorder symptom severity, MHRQoL, and BMI up to 6 and 12 months end of follow-up. Mid-treatment LOCE MTLOCE predicted improved MHRQoL (coefficient = 0.387, 95% CI 0.0824–0.6921, p = 0.004), reduced binge-eating frequency (IRR = 0.5637, 95% CI 0.3539–0.8977, p = 0.0191), and eating disorder symptom severity (coefficient= −0.65, 95% CI −1.0792–−0.2217, p = 0.0139). Neither purging nor illness duration were a significant predictor of any of the outcomes. The effect of HAPIFED was not moderated by baseline weight/BMI but was moderated negatively by MTLOCE for binge-eating frequency (coefficient = −0.636, SE = 0.28, p < 0.05, IRR = 0.529) and eating disorder symptom severity (coefficient = −0.268, SE = 0.13, p < 0.05, Cohen’s d = −0.102). Conclusions: Greater control over eating improved MHRQoL and decreased the frequency of binge-eating episodes and eating disorder symptom severity. These positive effects were moderated by being in the HAPIFED group, supporting previous findings of benefits to people’s mental health through participation in the HAPIFED trial. Full article

Introduction: Goal setting is an effective strategy in altering fitness and dietary behaviours. The goal attainment scale (GAS) is a patient-reported outcome measure that can be used to quantify goal achievement. The GAS has not been extensively assessed in lifestyle intervention trials. This study aimed to describe the goal setting process and assess the impact of a digital exercise and diet service and self-efficacy on goal attainment in people with chronic disease and at increased cardiometabolic risk. Methods: This study presents a single-centre, 26-week, randomised controlled trial (RCT) comparing standard care to digital health technologies (text messages, nutrition/exercise app, video consultations with dietitian and/or exercise physiologist). The comparator group was offered dietitian review (per standard care), and both groups received a wearable activity monitor. Individualised goal setting was facilitated prior to randomisation. Goal importance, performance measures, and self-efficacy were determined by participants. Goal outcome and ‘Change in GAS’ scores, reflecting the difference between baseline and follow-up performance, were calculated using validated formulae. Results: Goal setting was completed and reviewed by 66 participants, with a median age of 51 years and 56% being male. The most common goals related to weight loss (46%), fitness (29%), and diet (15%). Most participants (62%) reported improvements in their goals, with most improvements in dietary (71%), fitness (52%), and weight loss (39%) goals. There was no significant difference in goal outcomes between intervention and comparator groups (p = 0.99). There was, however, a significant correlation between nutrition self-efficacy and dietary goal achievement (p = 0.04). Conclusions: The novelty and feasibility of goal setting and attainment were demonstrated in this RCT of lifestyle interventions in people with chronic disease. Though the intervention did not significantly improve goal attainment, most participants reported improvements in their lifestyle goals. There were greater improvements in dietary goals than in fitness or weight loss goals. Participant-led goal setting with GAS and participant self-efficacy has potentially important applications in future lifestyle modification research and clinical implementation endeavours. Full article

This study investigates the influence of nanocellulose fibre (CF) derived from wood pulp on the hydration, mechanical, shrinkage, and pore properties of ordinary Portland cement (OPC) mortar. The CF was incorporated into mortar mixes at varying dosages (0.15–1.5% by weight of mortar) to evaluate its effect on physical, mechanical, and microstructure properties. X-ray diffraction (XRD), thermogravimetric analysis (TGA/DTG), and mercury intrusion porosimetry (MIP) were employed to assess the hydration phases and microstructural changes induced by the CF addition. Experimental results indicate that CF alters the hydration kinetics of cement mortar by influencing the formation of hydration products such as calcium silicate hydrate (C-S-H), portlandite (CH), and carbonate phases. The introduction of CF enhances crack resistance and shrinkage control, particularly at an optimal dosage of 0.45%, which exhibited reduced drying shrinkage and improved phase stability. While CF incorporation had minimal impact on compressive and flexural strength at lower dosages (≤0.45%), higher CF contents (>0.99%) caused pore structure modifications, leading to an increase in total porosity and a reduction in strength. The XRD analysis revealed that CF does not introduce new hydration phases but modifies the crystallinity of existing phases. The hydration behaviour, as indicated by TGA/DTG, showed an increase in bound water content at moderate CF dosages, suggesting enhanced internal curing and prolonged hydration. Overall, the findings demonstrate that CF is a viable sustainable additive for cementitious materials, offering advantages in shrinkage control, hydration enhancement, and durability improvement. The results suggest that an optimal CF dosage of 0.45% provides a balance between workability, mechanical properties, and durability, making it an effective additive for enhancing the performance of OPC mortars in sustainable construction applications. Full article

This study investigates the novel role of yarn-level fibre hybridisation in tailoring thermomechanical properties and thermal residual stress (TRS) fields in the resin at both micro- and meso-scales of 3D orthogonal-woven flax/E-glass hybrid composites. Unlike previous studies, which primarily focus on macro-scale composite behaviour, this work integrates a two-scale homogenisation scheme. It combines microscale representative volume element (RVE) models and mesoscale repeating unit cell (RUC) models to capture the effects of hybridisation from the fibre to lamina scale. The analysis specifically examines the cooling phase from a curing temperature of 100 °C down to 20 °C, where TRS develops due to thermal expansion mismatches. Microstructures are generated employing a random sequential expansion algorithm for RVE models, while weave architecture is generated using the open-source software TexGen 3.13.1 for RUC models. Results demonstrate that yarn-level hybridisation provides a powerful strategy to balance mechanical performance, thermal stability, and residual stress control, revealing its potential for optimising composite design. Stress analysis indicates that under in-plane tensile loading, stress levels in matrix-rich regions remain below 1 MPa, while binder yarns exhibit significant stress concentration, reaching up to 8.71 MPa under shear loading. The study quantifies how varying fibre hybridisation ratios influence stiffness, thermal expansion, and stress concentrations—bridging the gap between microstructural design and macroscopic composite performance. These findings highlight the potential of yarn-level fibre hybridisation in tailoring thermomechanical properties of yarns and laminae. The study also demonstrates its effectiveness in reducing TRS in composite laminae post-manufacturing. Additionally, hybridisation allows for adjusting density requirements, making it suitable for applications where weight and thermal properties are critical. Full article

Background: Dietary patterns play a crucial role in shaping eating behaviours and influencing health outcomes, such as body weight. Understanding how appetitive traits differ between plant-based and animal-based diets can provide insights into dietary strategies for weight management and improved health. Objectives: The aim of this study was to analyse the relationships between appetitive traits, as measured by the Adult Eating Behaviour Questionnaire (AEBQ), and dietary patterns in adults consuming plant-based or animal-based diets. It examined how these dietary patterns influence body mass index (BMI) and explored the differences in appetite-related traits between groups with different levels of plant and animal product consumption. Methods: A cross-sectional survey of 553 Polish adults was conducted using validated questionnaires, including the AEBQ and a food frequency questionnaire (FFQ). The participants were categorised into four dietary groups: high intake of both plant and animal products, low intake of both, plant-based diet, and animal-based diet. The data were analysed using SPSS version 14.0 software. Results: The participants on a plant-based diet had significantly lower BMIs and slower eating rates than those on an animal-based diet. Positive correlations were observed between ’food approach’ traits (e.g., food responsiveness, emotional overeating) and BMI, particularly in individuals with higher animal product consumption. Conversely, ’food avoidance’ traits (e.g., food fussiness, slowness in eating) were more prevalent among those on a plant-based diet. Conclusions: The results suggest that plant-based diets are associated with favourable appetitive traits and a lower BMI. These findings highlight the potential of plant-based diets to support weight control and improve eating behaviours. Further research is warranted to investigate the causal mechanisms underlying these associations. Full article

This study aimed to identify if sensor technology could be used to detect sickness-type signs (caused by a live vaccine) in laying hens compared to physiological and clinical sign scoring and behaviour observation. The experiment comprised 5 replicate batches (4 hens and 12 days per batch) using previously non-vaccinated hens (n = 20). Hens were moved on day 1 to a large experimental room with various designated zones (e.g., litter, perches, nest box), where they wore two sensors (FitBark, TrackLab). Saline was applied using ocular and nasal drops on day 3 as a control. A live vaccine (Infectious Laryngotracheitis, ILT, vaccine), applied using the same method on day 6, was used to induce mild respiratory and other responses. Physiological and clinical signs, and behaviour from videos were also recorded by a single observer. There were significant changes in body weight (p < 0.001), feed intake (p = 0.031), cloacal temperature (p < 0.001) and three out of five clinical signs (ocular discharge (p < 0.001), conjunctivitis (p < 0.001) and depression (p = 0.009)) over days. A significant decrease (p < 0.001) in activity level (FitBark) and distance travelled (both sensors) were identified over the study days, and activity and distance travelled were highly significantly associated (p < 0.001) with total clinical scores, with hens showing reduced activity and distance travelled with worsening total clinical scores. With behaviour observations from videos, the proportions of sitting, foraging and feeding behaviours (p = 0.044, 0.036 and 0.004, respectively), the proportion of total visit duration to the litter zone (p < 0.001) and perch (p = 0.037) with TrackLab and the proportions of visit counts of hens in the litter zone (p = 0.012) from video scanning changed significantly with days. This study suggests that the vaccine challenge caused associated changes in clinical/physiological signs and activity/distance travelled data from the sensors. Sensors may have a role in detecting changes in activity and movement in individual hens indicative of health or welfare problems. Full article

Pneumatic artificial muscles (PAMs) are flexible actuators that can be contracted or expanded by applying air pressure. They are used in robotics, prosthetics, and other applications requiring flexible and compliant actuation. PAMs are basically designed to mimic the function of biological muscles, providing a high force-to-weight ratio and smooth, lifelike movement. Inflation and deflation of these muscles can be controlled rapidly, allowing for fast actuation. In this work, a continuum mechanics-based model is developed to predict the output parameters of PAMs, like actuation force. Comparison of the model results with experimental data shows that the model efficiently predicts the mechanical behaviour of PAMs. Using the actuation force–air pressure–contraction relation provided by the proposed mechanical model, a dynamic model is derived for a multi-link PAM-actuated robot manipulator. An adaptive fixed-time fast terminal sliding mode control is proposed to track the desired joint position trajectories despite the model uncertainties and external disturbances with unknown magnitude bounds. Furthermore, the performance of the proposed controller is compared with an adaptive backstepping fast terminal sliding mode controller through numerical simulations. The simulations show faster convergence and more precise tracking for the proposed controller. Full article