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Keywords = trapezoid cross-section

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28 pages, 1790 KB  
Article
Stabilization of Floating Offshore Wind Turbines with a Passive Stability-Enhancing Skirted Trapezoidal Platform
by Hanbyeol Kim, Hassan Saghi, Injae Jeon and Goangseup Zi
J. Mar. Sci. Eng. 2025, 13(9), 1658; https://doi.org/10.3390/jmse13091658 - 29 Aug 2025
Viewed by 658
Abstract
In this study, an innovative passive stability-enhancing barge platform geometry is presented to improve the operational efficiency of floating offshore wind turbines (FOWTs) by mitigating platform motion caused by wave action. Barge-type FOWTs, which primarily rely on surface support, have received less attention [...] Read more.
In this study, an innovative passive stability-enhancing barge platform geometry is presented to improve the operational efficiency of floating offshore wind turbines (FOWTs) by mitigating platform motion caused by wave action. Barge-type FOWTs, which primarily rely on surface support, have received less attention in terms of geometric optimization. The proposed design incorporates skirts and a trapezoidal cross-sectional shape for the barge platforms.To achieve effective stability given cost-effect considerations, geometrical optimization was performed while maintaining the same mass as the original design. Positioning the skirt with a height-to-diameter ratio of 0.8 reduces platform movements considerably, decreasing the heave by approximately 20% and the pitch by up to 70% relative to the original design. In addition, the analysis demonstrated that increasing the moonpool area to approximately 400 m2 (approximately 10% of the platform’s surface area) led to an additional reduction in the heave and pitch responses. A specific moonpool diameter saturation point value was identified to increase the stability of the floater. Finally, the platform configuration yielded consistently lower peak motions across different wave angles, demonstrating improved stability. Full article
(This article belongs to the Special Issue Advanced Studies in Marine Structures)
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27 pages, 5055 KB  
Article
Physical–Mathematical Modeling and Simulations for a Feasible Oscillating Water Column Plant
by Fabio Caldarola, Manuela Carini, Alessandro Costarella, Gioia De Raffele and Mario Maiolo
Mathematics 2025, 13(14), 2219; https://doi.org/10.3390/math13142219 - 8 Jul 2025
Viewed by 654
Abstract
The focus of this paper is placed on Oscillating Water Column (OWC) systems. The primary aim is to analyze, through both mathematical modeling and numerical simulations, a single module (chamber) of an OWC plant which, in addition to energy production, offers the dual [...] Read more.
The focus of this paper is placed on Oscillating Water Column (OWC) systems. The primary aim is to analyze, through both mathematical modeling and numerical simulations, a single module (chamber) of an OWC plant which, in addition to energy production, offers the dual advantage of large-scale integration into port infrastructures or coastal defense structures such as breakwaters, etc. The core challenge lies in optimizing the geometry of the OWC chamber and its associated ducts. A trapezoidal cross-section is adopted, with various front wall inclinations ranging from 90° to 45°. This geometric parameter significantly affects both the internal compression ratio and the hydrodynamic behavior of incoming and outgoing waves. Certain inclinations revealed increased turbulence and notable interference with waves reflected from the chamber bottom which determined an unexpected drop in efficiency. The optimal performance occurred at an inclination of approximately 55°, yielding an efficiency of around 12.8%, because it represents the most advantageous and balanced compromise between counter-trend phenomena. A detailed analysis is carried out on several key parameters for the different configurations (e.g., internal and external wave elevations, crest phase shifts, pressures, hydraulic loads, efficiency, etc.) to reach the most in-depth analysis possible of the complex phenomena that come into play. Lastly, the study also discusses the additional structural and functional benefits of inclined walls over traditional parallelepiped-shaped chambers, both from a structural and construction point of view, and for the possible use for coastal defense. Full article
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15 pages, 2833 KB  
Article
Solid and Hollow Pre-Tensioned, Pre-Stressed Concrete Orchard Posts—Computational and Experimental Comparative Analysis
by Jarosław Michałek and Jacek Dudkiewicz
Materials 2025, 18(11), 2525; https://doi.org/10.3390/ma18112525 - 27 May 2025
Viewed by 1989
Abstract
For several years now, fruit-growers have increasingly often used pre-tensioned, pre-stressed concrete posts for supporting branches of fruit trees and suspending protective nets in order to limit damage to fruits caused by hail, wind, snow, heavy rainfall, insects and birds. Pre-tensioned, pre-stressed concrete [...] Read more.
For several years now, fruit-growers have increasingly often used pre-tensioned, pre-stressed concrete posts for supporting branches of fruit trees and suspending protective nets in order to limit damage to fruits caused by hail, wind, snow, heavy rainfall, insects and birds. Pre-tensioned, pre-stressed concrete posts most often have a trapezoidal cross-section, which is ideally suitable for mass production in a self-supporting non-dismantlable steel mould on a pre-stressing bed. Posts with 70 mm × 75 mm, 80 mm × 85 mm and 90 mm × 95 mm cross-sections are typically produced, whereas 100 mm × 120 mm and 130 mm × 140 mm posts are manufactured to order. Furthermore, it is proposed to produce hollow posts. Such posts are lighter than solid posts, but they require a more complicated production technology. This paper presents selected parts of a comparative computational–experimental analysis of solid and hollow posts. In the Building Structures Laboratory in the Building Structures Department at the Civil Engineering Faculty of the Wrocław University of Science and Technology, experimental tests of pre-stressed concrete orchard posts of 70 mm × 75 mm and 90 mm × 95 mm with solid and hollow cross-sections were carried out on a full scale. The theoretical analysis and research has shown that the resistance to bending, cracking resistance and rigidity of hollow posts (with their cross-sectional outline unchanged) will not significantly differ from those of the currently produced solid posts. At same time, material savings will be achieved. Therefore, the main task is to master the continuous moulding of hollow posts from dense plastic concrete with the simultaneous pulling out of the cores, producing longitudinal hollows in the posts. Full article
(This article belongs to the Special Issue Study on Mechanical Properties of Concrete Structures and RC Beams)
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18 pages, 14806 KB  
Article
Cross-Section Shape and Asymmetric Support Technology of Steeply Inclined Thick Coal Seam Roadway
by Fan Li, Baisheng Zhang, Junqing Guo, Zetian Li, Yanwen Xie, Qi Xu and Dong Duan
Appl. Sci. 2025, 15(11), 5976; https://doi.org/10.3390/app15115976 - 26 May 2025
Viewed by 525
Abstract
The dip angle and thickness of coal seams are key geological determinants in mine system engineering. Roadways excavated in steeply inclined or thick coal seams typically exhibit significant deformation, with the combined geological configuration of steeply inclined thick seams thus presenting heightened support [...] Read more.
The dip angle and thickness of coal seams are key geological determinants in mine system engineering. Roadways excavated in steeply inclined or thick coal seams typically exhibit significant deformation, with the combined geological configuration of steeply inclined thick seams thus presenting heightened support demands. Therefore, taking the 1502 level roadway in the Dayuan Coal Industry—situated in a steeply inclined thick coal seam—as an engineering case, mechanical models of roadways with different cross-sectional shapes are established, and the deformation and failure mechanisms of surrounding rock under different coal seam dip angles are analyzed. Based on this analysis, an asymmetric support technology scheme is proposed, followed by surrounding rock deformation monitoring and a support effectiveness evaluation. Key findings include the following: (1) in steeply inclined thick coal seam roadways with different cross-sectional shapes, the stress distribution and plastic zone development of surrounding rock follow a descending sequence, inclined roof trapezoidal section > rectangular section > arched section. Among these, the arched section is identified as the optimal roadway cross-sectional shape for this engineering context. (2) The stress-concentration area in the arch roadway aligns with the inclined direction of the coal seam, forming asymmetric stress concentration patterns. Specifically, as the coal seam dip angle increases, stress increases at the arch shoulder of the upper sidewall and the wall foundation of the lower sidewall. Concurrently, such stress concentration induces shear failure in the surrounding rock, which serves as the primary mechanism causing asymmetric deformation and failure in steeply inclined thick coal seam roadways. (3) In the 1502 level roadway, the asymmetric support technology with dip-oriented reinforcement was implemented. Compared to the original support scheme, roof deformation and sidewall convergence decreased by 46.17% and 46.8%, respectively. The revealed failure mechanisms of steeply inclined thick coal seam roadways and the proposed asymmetric support technology provide technical and engineering references for roadway support in similar mining conditions. Full article
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15 pages, 3318 KB  
Article
Designing Long-Throated Flumes for Improved Water Management in Rice Cultivation: A New Automated Approach
by María Fátima Moreno-Pérez, Francisco Javier Pérez-Ardoy and José Roldán-Cañas
Water 2025, 17(8), 1137; https://doi.org/10.3390/w17081137 - 10 Apr 2025
Viewed by 602
Abstract
Rice is irrigated by flooding, maintaining constant water levels and achieving high water requirements. At the outlet of the plot is a drainage canal whose monitoring using a long-throated flume to determine the flow rate leaving the plot allows for the establishment of [...] Read more.
Rice is irrigated by flooding, maintaining constant water levels and achieving high water requirements. At the outlet of the plot is a drainage canal whose monitoring using a long-throated flume to determine the flow rate leaving the plot allows for the establishment of practices to reduce highwater consumption. Since the drainage channel has a trapezoidal cross-section and is built on land, the throat of the flume is also trapezoidal to ease the transition between the two sections and to reduce head losses. Herein, a new accurate procedure is developed that provides a quick and automated design of a long-throated flume. This method allows direct calculation of the dimensions of the narrowed section, side slope, and bottom width by choosing the modular limit, the sill height, and the length of the throat based on the characteristics of the channel where the flume is to be installed. The new process is applied to the design of a long-throated flume that allows us to measure the entire range of flow rates required. The design developed based on our methodology is evaluated using the WinFlume Version 2.1 software, and the results obtained demonstrate its strength and suitability. The modular limit values considered (between 0.5 and 0.8) ensure a significant reduction in head losses as water passes through. Full article
(This article belongs to the Special Issue Open Channel Flows: An Open Topic That Requires Further Exploration)
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16 pages, 3595 KB  
Article
Evolutionary Algorithm-Based Design and Performance Evaluation of Wood–Plastic Composite Roof Panels for Low-Cost Housing
by Bassel Abdelshahid, Khaled Nassar, Passant Youssef, Ezzeldin Sayed-Ahmed and Mohamed Darwish
Polymers 2025, 17(6), 795; https://doi.org/10.3390/polym17060795 - 17 Mar 2025
Cited by 2 | Viewed by 1020
Abstract
Wood–plastic composites (WPCs) have emerged as a sustainable and cost-effective material for construction, particularly in low-cost housing solutions. However, designing WPC panels that meet structural, serviceability, and manufacturing constraints remains a challenge. This study focused on optimizing the cross-sectional shape of WPC roof [...] Read more.
Wood–plastic composites (WPCs) have emerged as a sustainable and cost-effective material for construction, particularly in low-cost housing solutions. However, designing WPC panels that meet structural, serviceability, and manufacturing constraints remains a challenge. This study focused on optimizing the cross-sectional shape of WPC roof panels using evolutionary algorithms to minimize material usage while ensuring compliance with deflection and stress constraints. Two evolutionary algorithms—the genetic algorithm (GA) and particle swarm optimization (PSO)—were employed to optimize sinusoidal and trapezoidal panel profiles. The optimization framework integrated finite element analysis (FEA) to evaluate structural performance under uniformly distributed loads and self-weight. The modulus of elasticity of the WPC material was determined experimentally through three-point bending tests, ensuring accurate material representation in the simulations. The trapezoidal profile proved to be the most optimal, exhibiting superior deflection performance compared with the sinusoidal profile. A comparative analysis of GA and PSO revealed that PSO outperformed GA in both solution optimality and convergence speed, demonstrating its superior efficiency in navigating the design space and identifying high-performance solutions. The findings highlight the potential of WPCs in low-cost housing applications and offer insights into the selection of optimization algorithms for similar engineering design problems. Full article
(This article belongs to the Special Issue Polymers in Civil Engineering)
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12 pages, 689 KB  
Article
Modeling Diffusion of Elongated Particles Through a Narrowing Channel
by Anna Strzelewicz, Michał Cieśla, Bartłomiej Dybiec and Monika Krasowska
Entropy 2025, 27(3), 293; https://doi.org/10.3390/e27030293 - 12 Mar 2025
Cited by 1 | Viewed by 902
Abstract
Simulations of the Brownian dynamics of diffusing particles in complex environments provide important information about the characteristics of the medium and the properties of biological processes. Notable examples include the diffusion of ions and macromolecular solutes through channels of varying cross-section, such as [...] Read more.
Simulations of the Brownian dynamics of diffusing particles in complex environments provide important information about the characteristics of the medium and the properties of biological processes. Notable examples include the diffusion of ions and macromolecular solutes through channels of varying cross-section, such as pores in biological membranes, living tissues, zeolites, carbon nanotubes, and synthetic porous materials. In these systems, the observed diffusion can exhibit anomalous behavior characterized by a nonlinear increase in the mean squared displacement. In this article, we present a toy model of the diffusion of rod-shaped particles through a narrowing, conical pore with a trapezoidal longitudinal cross-section. Particles of different sizes undergo a random walk due to interactions with the environment (modeled as noise). We study how the diffusion properties change with particle size as a function of pore width. The numerical analysis of diffusion-driven transport through narrowing conical channels reveals its effective subdiffusive, i.e., anomalous, character. Full article
(This article belongs to the Collection Disorder and Biological Physics)
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16 pages, 5936 KB  
Article
Effect of Topographic Condition of Drainage Channel on the Interaction Between Granular Flow and Slit Dams
by Jiajia Feng, Chengye Yang, Chongyang Bu, Yangyang Xia and Gen Zhang
Sustainability 2025, 17(4), 1649; https://doi.org/10.3390/su17041649 - 17 Feb 2025
Cited by 2 | Viewed by 728
Abstract
One of the most dangerous geological disaster risks in mountainous areas is granular flow. Slit dams, which might partially block the granular flow and let downstream flow at a slower speed, have been crucial in reducing the geohazards associated with granular flow. In [...] Read more.
One of the most dangerous geological disaster risks in mountainous areas is granular flow. Slit dams, which might partially block the granular flow and let downstream flow at a slower speed, have been crucial in reducing the geohazards associated with granular flow. In this work, the discrete element method (DEM) was used to explore the effect of the topographic condition of drainage channels, including slope angle and cross-section types, on the interaction between granular flows and slit dams. The interactions dynamic process between the dry granular flows and slit dams with different drainage channel cross-section types has been investigated. And the simulation results demonstrate the significance of taking drainage channel cross-section types into account when designing barriers, particularly slit dams. The flow process, particularly in channels with V-shaped and trapezoidal sections, is characterized by a more rapid movement and larger final accumulation length, potentially resulting in increased impact force on the downstream slit dams. Moreover, the cross-section types and slope angles jointly influence the regulation function and impact force. The dry granular flow in the drainage channel with a V-shaped cross-section leads to a smaller normal impact force and retention efficiency. Taking into account the complexity of construction, retention efficiency, and impact force, it can be concluded that a trapezoid shape is the most appropriate option from an engineering perspective. This research may add to the understanding of the relationship between granular flow and slit dams and help the engineering design of slit dams with scientific evidence. Full article
(This article belongs to the Section Hazards and Sustainability)
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19 pages, 8676 KB  
Article
Experimental Study on the Uplift Bearing Capacity of Pre-Drilled Planted Piles in Isolated Stone Strata Based on Transparent Soil Technology
by Wenli Liao, Qipeng Cai, Xiangyu Guo, Hao Lin, Jiajin Zhou and Shizhuo Su
Appl. Sci. 2025, 15(1), 304; https://doi.org/10.3390/app15010304 - 31 Dec 2024
Cited by 1 | Viewed by 1102
Abstract
The presence of isolated stones in the soil layers of engineering sites has significantly increased. Currently, the existing methods for dealing with isolated stones are inadequate to meet engineering needs. This paper combines pile-planting technology with isolated stones to incorporate them into the [...] Read more.
The presence of isolated stones in the soil layers of engineering sites has significantly increased. Currently, the existing methods for dealing with isolated stones are inadequate to meet engineering needs. This paper combines pile-planting technology with isolated stones to incorporate them into the load-bearing system, resulting in a new type of pre-drilled composite pile suitable for isolated stone sites. A visualization testing system for pile-soil deformation is developed using Particle Image Velocimetry (PIV) technology and transparent soil, conducting non-intrusive model tests on pile-planting and boulder-capped piles under different uplift load conditions, and comparing the results with a discrete-continuous coupled three-dimensional numerical model analysis. The results indicate that when an isolated stone with a cross-sectional area four times that of the pile exists at the pile tip, the ultimate pullout bearing capacity of the pile increases by a factor of two. Regarding the distribution of internal and external side friction resistances of the core and outer concrete of the piles, the internal friction resistance of piles without isolated stones is approximately 1.47 times that of the external friction resistance and about 0.8 times the ratio of the diameters of the pile and core. For piles with isolated stones at the tip, the internal friction resistance is approximately 1.37 times that of the external friction resistance. Under the ultimate load, the displacement field around the pile without an isolated stone exhibits an “inverted triangular” distribution; the displacement field around the pile with an isolated stone at the tip exhibits a “trapezoidal” distribution. This study investigates the bearing capacity and load transfer mechanisms of the new pre-drilled composite piles in isolated stone engineering sites, and the research findings may provide new solutions for similar construction projects involving rubble reclamation. Full article
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14 pages, 5473 KB  
Article
A Novel Design Method for Chip Flute of Indexable Insert Drill Used at Large Drilling Depth
by Aisheng Jiang, Zhanqiang Liu and Jinfu Zhao
Metals 2024, 14(12), 1351; https://doi.org/10.3390/met14121351 - 27 Nov 2024
Viewed by 1213
Abstract
The design of the chip flute in indexable insert drills significantly influences chip removal efficiency, drill diameter deflection, and drill deformation in the metal drilling process, which are crucial for maintaining drill stability and minimizing deviations in the diameter of the drilled hole. [...] Read more.
The design of the chip flute in indexable insert drills significantly influences chip removal efficiency, drill diameter deflection, and drill deformation in the metal drilling process, which are crucial for maintaining drill stability and minimizing deviations in the diameter of the drilled hole. However, traditional chip flute designs fail to meet production standards when drilling deep holes in 42CrMo, particularly at depths reaching up to seven times the hole diameter. This study introduces an innovative optimization method for the chip flute design of indexable insert drills specifically intended for metal deep-cutting applications, which involves refining both the cross-sectional and circumferential profiles of the chip flute. A novel combined cross-section for the chip flute was developed and tested against the conventional double U-profile in drilling experiments on 42CrMo. Based on the chip shape of the inner and outer inserts, the inner insert flute section is designed into a U-shaped section and the outer insert flute section is designed into trapezoidal section, respectively, so as to increase the proportion of the effective chip removal area in the chip flute, which reduces the chip flute section area and increases the core thickness of the tool holder. Additionally, the circumferential profile was enhanced through orthogonal simulation experiments. The findings revealed that the drill diameter deflection using the newly designed combined cross-section was reduced by 21.76% compared to the traditional double U-profile in the metal drilling process. The indexable insert drill featuring this optimized chip flute configuration exhibited significant improvements in the drill diameter deflection, drill deformation, and drilled hole diameter accuracy, outperforming the standard drill design. Full article
(This article belongs to the Special Issue Advances in Metal Cutting and Machining Processes)
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15 pages, 4530 KB  
Article
Numerical Assessment of the Thermal Performance of Microchannels with Slip and Viscous Dissipation Effects
by Pamela Vocale and Gian Luca Morini
Micromachines 2024, 15(11), 1359; https://doi.org/10.3390/mi15111359 - 8 Nov 2024
Cited by 1 | Viewed by 1048
Abstract
Microchannels are widely used across various industries, including pharmaceuticals and biochemistry, automotive and aerospace, energy production, and many others, although they were originally developed for the computing and electronics sectors. The performance of microchannels is strongly affected by factors such as rarefaction and [...] Read more.
Microchannels are widely used across various industries, including pharmaceuticals and biochemistry, automotive and aerospace, energy production, and many others, although they were originally developed for the computing and electronics sectors. The performance of microchannels is strongly affected by factors such as rarefaction and viscous dissipation. In the present paper, a numerical analysis of the performance of microchannels featuring rectangular, trapezoidal and double-trapezoidal cross-sections in the slip flow regime is presented. The fully developed laminar forced convection of a Newtonian fluid with constant properties is considered. The non-dimensional forms of governing equations are solved by setting slip velocity and uniform heat flux as boundary conditions. Model accuracy was established using the available scientific literature. The numerical results indicated that viscous dissipation effects led to a decrease in the average Nusselt number across all the microchannels examined in this study. The degree of reduction is influenced by the cross-section, aspect ratio and Knudsen number. The highest reductions in the average Nusselt number values were observed under continuum flow conditions for all the microchannels investigated. Full article
(This article belongs to the Section A:Physics)
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14 pages, 7171 KB  
Article
Quantitative Analysis of Magnetic Force of Axial Symmetry Permanent Magnet Structure Using Hybrid Boundary Element Method
by Ana Vučković, Dušan Vučković, Mirjana Perić and Branislav M. Ranđelović
Symmetry 2024, 16(11), 1495; https://doi.org/10.3390/sym16111495 - 8 Nov 2024
Cited by 1 | Viewed by 1467
Abstract
This paper investigates the forces generated by axially magnetized ring permanent magnets with trapezoidal cross-sections when placed near a soft magnetic cylinder. Utilizing the Hybrid Boundary Element Method (HBEM), this study models interactions in magnetic configurations, aiming to improve force calculation efficiency and [...] Read more.
This paper investigates the forces generated by axially magnetized ring permanent magnets with trapezoidal cross-sections when placed near a soft magnetic cylinder. Utilizing the Hybrid Boundary Element Method (HBEM), this study models interactions in magnetic configurations, aiming to improve force calculation efficiency and accuracy compared to traditional finite element methods (FEMM 4.2 software program). The influence of the permanent magnet and the soft magnetic cylinder is approximated with a system of thin toroidal sources on the surfaces of the magnet and the cylinder, which significantly reduces the computation time for the force calculation. The approach is validated by comparing results with FEM solutions, revealing high precision with a much faster computation. Additionally, this study explores the influence of various parameters, including magnet size, separation distance, and magnetic permeability of the cylinder, on the magnetic force. The results demonstrate that the HBEM approach is effective for analyzing complex magnetic configurations, particularly in applications requiring efficient parametric studies. This approach can be adapted for other geometries, such as truncated cones or rectangular cross-section ring magnets. The findings contribute valuable insights into designing efficient magnetic systems and optimizing force calculations for varied magnet geometries and configurations, including the atypical ones. Full article
(This article belongs to the Section Engineering and Materials)
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18 pages, 10630 KB  
Article
Influence of Volute Casing Design Methods and Changes in Geometric Parameters on Pump Operation
by Anna Chernobrova, Oleksandr Moloshnyi and Piotr Szulc
Energies 2024, 17(18), 4590; https://doi.org/10.3390/en17184590 - 13 Sep 2024
Cited by 1 | Viewed by 2625
Abstract
This article presents results from research whose purpose is to determine the impact of two main factors on the operational efficiency of a double-entry centrifugal pump. The first factor is the design methods, and the second is changes in the geometric parameters for [...] Read more.
This article presents results from research whose purpose is to determine the impact of two main factors on the operational efficiency of a double-entry centrifugal pump. The first factor is the design methods, and the second is changes in the geometric parameters for the volute casing. The results of the numerical simulation were experimentally validated on a test stand. Within this study, volute casings were designed according to the constant velocity method and method of conservation of angular momentum of the flow. The geometric parameters were selected according to the recommendation of A. Stepanoff and A. Lomakin. Next, the following geometric parameters were changed: inlet diameter, inlet width, cross-sectional area, shape of the volute casing’s cross-section (trapezoidal vs. round) and the opening angle of the volute casing’s walls. A comparison of the two methods showed that the biggest difference between them is the influence on the shape of the pump characteristic curve. Altering the geometric parameters in trapezoidal or round volute casing cross-sections had minimal impact on the pump head and efficiency. Full article
(This article belongs to the Section I: Energy Fundamentals and Conversion)
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35 pages, 48192 KB  
Review
Lab-on-Chip Systems for Cell Sorting: Main Features and Advantages of Inertial Focusing in Spiral Microchannels
by Isabella Petruzzellis, Rebeca Martínez Vázquez, Stefania Caragnano, Caterina Gaudiuso, Roberto Osellame, Antonio Ancona and Annalisa Volpe
Micromachines 2024, 15(9), 1135; https://doi.org/10.3390/mi15091135 - 6 Sep 2024
Cited by 7 | Viewed by 7832
Abstract
Inertial focusing-based Lab-on-Chip systems represent a promising technology for cell sorting in various applications, thanks to their alignment with the ASSURED criteria recommended by the World Health Organization: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Delivered. Inertial focusing techniques using spiral [...] Read more.
Inertial focusing-based Lab-on-Chip systems represent a promising technology for cell sorting in various applications, thanks to their alignment with the ASSURED criteria recommended by the World Health Organization: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Delivered. Inertial focusing techniques using spiral microchannels offer a rapid, portable, and easy-to-prototype solution for cell sorting. Various microfluidic devices have been investigated in the literature to understand how hydrodynamic forces influence particle focusing in spiral microchannels. This is crucial for the effective prototyping of devices that allow for high-throughput and efficient filtration of particles of different sizes. However, a clear, comprehensive, and organized overview of current research in this area is lacking. This review aims to fill this gap by offering a thorough summary of the existing literature, thereby guiding future experimentation and facilitating the selection of spiral geometries and materials for cell sorting in microchannels. To this end, we begin with a detailed theoretical introduction to the physical mechanisms underlying particle separation in spiral microfluidic channels. We also dedicate a section to the materials and prototyping techniques most commonly used for spiral microchannels, highlighting and discussing their respective advantages and disadvantages. Subsequently, we provide a critical examination of the key details of inertial focusing across various cross-sections (rectangular, trapezoidal, triangular, hybrid) in spiral devices as reported in the literature. Full article
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15 pages, 3372 KB  
Article
A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section
by Shijie Lu, Ding Ma and Xianqiang Mi
Sensors 2024, 24(11), 3552; https://doi.org/10.3390/s24113552 - 31 May 2024
Cited by 4 | Viewed by 2109
Abstract
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a [...] Read more.
Circulating tumor cells are typically found in the peripheral blood of patients, offering a crucial pathway for the early diagnosis and prediction of cancer. Traditional methods for early cancer diagnosis are inefficient and inaccurate, making it difficult to isolate tumor cells from a large number of cells. In this paper, a new spiral microfluidic chip with asymmetric cross-section is proposed for rapid, high-throughput, label-free enrichment of CTCs in peripheral blood. A mold of the desired flow channel structure was prepared and inverted to make a trapezoidal cross-section using a micro-nanotechnology process of 3D printing. After a systematic study of how flow rate, channel width, and particle concentration affect the performance of the device, we utilized the device to simulate cell sorting of 6 μm, 15 μm, and 25 μm PS (Polystyrene) particles, and the separation efficiency and separation purity of 25 μm PS particles reached 98.3% and 96.4%. On this basis, we realize the enrichment of a large number of CTCs in diluted whole blood (5 mL). The results show that the separation efficiency of A549 was 88.9% and the separation purity was 96.4% at a high throughput of 1400 μL/min. In conclusion, we believe that the developed method is relevant for efficient recovery from whole blood and beneficial for future automated clinical analysis. Full article
(This article belongs to the Special Issue Advancements in Microfluidic Technologies and BioMEMS)
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