Search Results (12,273)

Limited by the computational performance limits of the CPU(Central Processing Unit), the traditional Spark architecture struggles to achieve high throughput and low latency under the dual pressure of a large data scale and real-time requirements in centralized control systems. This work uses a publicly available CNC(Computer Numerical Control) milling dataset as a functional validation proxy for time-series data processing, then extends validation to a large-scale synthetic power transmission grid dataset. Furthermore, Spark-GPU(Graphics Processing Unit) collaboration suffers from load balancing failure due to heterogeneous resource scheduling and communication overhead, thus failing to unleash its performance potential. This paper proposes a Spark-GPU fusion acceleration technology path. The path consists of three key components: first, it integrates the RAPIDS accelerator; second, it designs a GPU-aware partitioning and task co-scheduling strategy; and third, it optimizes the zero-copy data path. Together, these components realize an integrated collaboration of heterogeneous resources. Validation on real-world datasets yields the following results. In real-time aggregation scenarios, the proposed solution improves throughput by a factor of 3.7 over the pure CPU baseline and reduces end-to-end latency by 62%. Compared with the basic GPU solution, GPU utilization rises from 51.7% to 72.3%, representing a relative improvement of 39.8%. Furthermore, the solution meets industrial-grade high availability requirements. This research significantly improves the processing throughput and reduces end-to-end latency in typical centralized control scenarios, thus providing a feasible technical route for demanding concurrent centralized control scenarios such as electric power industry manufacturing with high real-time demands. Full article

Melatonin occupies a paradoxical position in contemporary sleep medicine: despite its physiological role as a regulator of circadian timing, it is frequently used and perceived as a nonspecific “natural” hypnotic. Although melatonin demonstrates modest benefits for sleep initiation and clearer efficacy in circadian rhythm sleep–wake disorders, its clinical use is often undermined by diagnostic imprecision, inappropriate dosing, mistimed administration, inconsistent formulations, and inadequate patient counseling. Circadian disorders can be misclassified as primary insomnia, leading to symptomatic treatment approaches that fail to address the underlying phase misalignment. At the same time, supraphysiological doses and reflexive bedtime administration have become normalized despite evidence that melatonin acts primarily as a chronobiotic whose effects depend more on timing than dose. Regulatory inconsistencies and substantial variability in over-the-counter preparations further complicate safe and reproducible use. These factors contribute to avoidable treatment failure, inaccurate labeling of nonresponse, and persistent misconceptions regarding melatonin’s mechanism of action. Therefore, melatonin should be approached as a pharmacological intervention requiring the same diagnostic rigor, individualized dosing, and longitudinal assessment expected of other sleep therapeutics, particularly when integrated with behavioral and circadian interventions. Full article

Power cycling reliability is one of the most widely used frameworks to evaluate the lifetimes of power semiconductor switching devices from a thermal stress perspective. Experimental tests can be used to predict their lifetimes under operating conditions. An estimation of the number of cycles to failure $N_f$ can also be given by several lifetime models, which express the number of cycles to end of life as a function of empirical coefficients. In the existing literature, these empirical coefficients are generally estimated using the classical least squares method (to find the best-fitting line through data points), where outliers are removed using the Random Sample Consensus algorithm. The aim of this paper is to present a general strategy for the calculation of empirical coefficients for different lifetime models, such as Coffin–Manson, Coffin–Manson–Arrhenius, Norris–Landzberg, and simplified Bayerer, aiming at minimizing the number of required experimental tests. The results show that the number of experimental trials required varies between two and four, depending on the number of empirical coefficients to be determined, which is specific to the lifetime model used. Furthermore, a limited number of experimental data points are selected to avoid any degradation in accuracy. The accuracy of coefficient estimation is significantly improved by excluding outliers: some relative errors decrease by 25%. Additionally, each empirical coefficient is determined under specific thermal stress conditions, such as a constant junction temperature swing $\mathsf{\Delta }{T}_j$, constant current per bond wire I, constant cycling frequency f, or constant mean junction temperature $T_{jm}$. Furthermore, a limited number of experimental data are selected to avoid any degradation in accuracy due to outliers. Moreover, this general method can be applied to all power devices, such as IGBTs or MOSFETs. Finally, the limitations of the analytical solution for the Scheuermann lifetime model are discussed. Full article

Suspended ceiling systems are among the most seismically vulnerable non-structural components in buildings, posing significant life-safety risks and economic losses, yet understanding their full-field kinematic behavior under seismic loading remains a major experimental challenge. Conventional contact sensors offer limited spatial coverage and can alter the dynamic properties of lightweight panels due to mass loading. In contrast, non-contact optical alternatives are rarely feasible in shake-table environments due to restricted viewing angles, extensive areal coverage requirements, and the risk of equipment damage from falling panels. This study proposes an end-to-end three-dimensional displacement measurement framework for large-scale shake-table testing of suspended ceiling systems, employing consumer-grade cameras with purpose-built tools that cover the complete experimental workflow, including motion-based video trimming, semi-automated calibration, a robust multi-stage image-tracking pipeline that maintains trajectory continuity under extreme inter-frame displacements, and a ceiling system motion visualization and analysis tool. The framework was validated through a full-scale shake-table experiment continuously tracking 324 spatial nodes across 81 ceiling panels, achieving an RMSE below 3 mm in all spatial directions and exact peak-frequency agreement in 9 out of 10 test cases. A parallel processing architecture reduced total processing time from over 27 h to under 10 min without GPU acceleration, and six-degree-of-freedom rigid-body analysis resolved the complete panel failure sequence from constrained oscillation through multi-axis rotation to gravitational free fall, a level of kinematic detail unattainable with conventional instrumentation. This framework establishes a practical, scalable foundation for full-field seismic performance assessment of non-structural systems where conventional instrumentation is physically or logistically infeasible. Full article

To mitigate driving risks from brake failure on long and steep downhill sections, this study designs three deployment schemes for radar–video fusion devices: a baseline scenario with no coverage, a scenario with partial coverage in high-risk areas, and a scenario with full coverage. Corresponding information service strategies are delivered via Human–Machine Interfaces (HMIs), forming an integrated active prevention and control framework from risk perception to preventive action. Driving simulation experiments focusing on the car-following process were conducted to collect vehicle operational data and extract characteristic indicators based on the Wiedemann model. A Generalized Linear Mixed Model was employed to comprehensively examine the effects of HMIs on car-following behavior to identify the optimal active prevention strategy. Results show that drivers exhibit greater caution under the partial coverage scheme, with time headway increasing by 47.63% compared to the scheme with no radar–video fusion devices to ensure safety. Under full coverage conditions, drivers can obtain real-time information about the leading vehicle’s status and the distance between the two vehicles in key risk sections. Drivers choose to follow the leading vehicle, balancing both safety in car-following and efficiency on long and steep downhill sections. As the level of accompanying services improves, drivers engage in self-regulation to avoid rear-end collisions. Particularly under the scheme with full coverage of radar–video fusion devices, the standing distance significantly increases by 219.37% compared to the partial coverage condition. Drivers demonstrate optimal vehicle control capabilities. Furthermore, there is an interaction effect between the accompanying service strategy and drivers’ attributes on car-following behaviors. Under different schemes, more experienced drivers exhibit a certain degree of aggressiveness, providing a basis for the targeted design of information services for different types of drivers. The findings support the deployment and application of risk perception and prevention devices on long and steep downhill sections, which can effectively enhance the comprehensive safety of such special roads in the connected vehicle environment. Full article

Rolling bearings, as core components of rotating machinery, are prone to failure under harsh working conditions, and their fault diagnosis is crucial for the safe operation of industrial systems. Aiming at resolving the problems of weak fault feature representation, poor model generalization ability and high dependence on manual preprocessing in traditional bearing fault diagnosis methods, an end-to-end fault diagnosis model named KanMSConv is proposed for one-dimensional raw vibration signals. The model abandons complex time–frequency transformation and manual feature engineering, and constructs a multi-scale feature extraction module based on depthwise separable convolution to capture local impulsive components and global modulation characteristics of fault signals simultaneously. The SE channel attention mechanism is integrated to adaptively enhance fault-related critical features and reduce redundant channel responses. Residual connection is introduced to alleviate the gradient degradation problem of deep networks and improve feature reuse capability. On this basis, the Kolmogorov–Arnold Network (KAN) is used to replace the traditional fully connected layer, which enhances the model’s ability to fit complex nonlinear mapping relationships and distinguish fault classification boundaries. Experimental verification is carried out on three representative rolling bearing datasets (CWRU, PU, SDUST) under multi-load, multi-class and cross-platform conditions. The results show that the KanMSConv model achieves 100% accuracy on the CWRU dataset, 99.93% on the PU dataset and 99.80% on the SDUST dataset, which is significantly superior to the existing mainstream fault diagnosis models in terms of Accuracy, Precision, Recall and F1-Score. And the ablation and computational cost analyses further support this conclusion. Full article

Background: Early and accurate risk stratification of patients suspected of serious infection is essential for improving outcomes, but existing diagnostic and predictive tools have limited accuracy. The objective was to compare the performance of an FDA-authorized AI diagnostic test, the Sepsis ImmunoScore, against widely available biomarkers and clinical tools for diagnosis of sepsis and prediction of in-hospital mortality and intensive care unit (ICU) admission. Methods: This multicenter observational study included 6027 adult patients suspected of infection across 7 U.S. hospital sites. The Sepsis ImmunoScore’s predictive performance was compared to the sequential organ failure assessment (SOFA) score, procalcitonin (PCT), C-reactive protein (CRP), Systemic Inflammatory Response Syndrome (SIRS) score, National Early Warning Score (NEWS), and quick SOFA (qSOFA). Primary outcomes included sepsis as defined by Sepsis-3 criteria, in-hospital mortality, and ICU admission. Predictive accuracy was assessed using area under the receiver operating characteristic curve (AUC), and 95% confidence intervals were generated and hypothesis testing conducted using the bootstrap method. Results: The Sepsis ImmunoScore demonstrated statistically significant superior performance across all outcomes. For sepsis prediction, the Sepsis ImmunoScore achieved an AUC of 0.82, compared to SOFA (0.72), procalcitonin (PCT) (0.70), C-reactive protein (CRP) (0.61), SIRS (0.59), NEWS (0.69), and qSOFA (0.67). For in-hospital mortality prediction, the Sepsis ImmunoScore achieved an AUC of 0.80, outperforming SOFA (0.72), PCT (0.67), CRP (0.58), SIRS (0.60), NEWS (0.72), and qSOFA (0.69). For ICU admission, the Sepsis ImmunoScore reached an AUC of 0.74, superior to SOFA (0.63), PCT (0.64), CRP (0.54), SIRS (0.60), NEWS (0.70), and qSOFA (0.65). All differences between the Sepsis ImmunoScore and comparators were statistically significant. Conclusions: The Sepsis ImmunoScore significantly improved predictive accuracy for sepsis, in-hospital mortality, and ICU admission compared to six conventional clinical scores and biomarkers. This AI-based tool may enhance risk stratification and clinical decision-making, potentially leading to more timely sepsis interventions and improved outcomes. Full article

Objective: Pediatric intestinal pseudo-obstruction (PIPO) is a rare, severe, and heterogeneous gastrointestinal motility disorder associated with intestinal failure, recurrent hospitalizations, and significant morbidity and mortality. This study aimed to evaluate the clinical features, management strategies, and long-term outcomes of children diagnosed with PIPO at a tertiary referral center. Methods: This retrospective single-center study included pediatric patients diagnosed with PIPO between 2011 and 2025. Diagnosis was established according to ESPGHAN consensus criteria. Demographic characteristics, clinical presentation, genetic findings, nutritional support, surgical interventions, intestinal transplantation, and long-term outcomes were retrospectively reviewed. Results: A total of 32 patients with PIPO were included, of whom 56.2% were female and 43.7% had early-onset disease. Genetic testing was performed in 22 of 32 patients; clinically significant variants were identified in 16 (50% of the total cohort), most commonly ACTG2 mutations. Prior abdominal surgery before referral was present in 84.3% of patients. During follow-up, 56% remained parenteral nutrition dependent, five patients underwent intestinal transplantation, and the overall mortality rate was 21.8%. Conclusions: PIPO is a highly heterogeneous disorder associated with substantial morbidity, prolonged nutritional support requirements, repeated surgical interventions, and significant mortality. Early diagnosis, genetic evaluation, multidisciplinary management, and timely referral to specialized intestinal failure and transplantation centres are likely to support more individualised management and may help prevent avoidable complications in affected children. Full article

Water loss and significant problems in the operation of water distribution networks caused by pipe failures are a global problem that needs immediate attention. This study is based on the experience-based assumption that the probability of water main breaks occurring is highest within a short time and a short distance from a previous (considered initial or base) break. The dataset used includes the historical pipe breaks recorded from 2007 to 2020 in the city of Larisa, Greece. A Geographic Information System (GIS) application is used for better data visualization, but also for effective operation and management of the developed water network database. Cluster analysis and Near and Spatial Join geoprocessing tools are the main tools used to detect and analyze trends in data related to space and time. In addition, the study attempts to identify relations between pipe attributes (material, age), environmental stressors (traffic load, soil type), and spatiotemporal clustering patterns. Finally, a machine learning-based water pipe failure Prediction Model is developed to serve as the computational engine of a Decision Support System (DSS) designed to optimize pipe replacement prioritization. Full article

Indoor air quality has a significant impact on occupant health, comfort, and productivity in residential and commercial indoor environments. This paper proposes an IoT-edge enabled deep–fuzzy hybrid framework for real-time IAQ prediction and adaptive control. The proposed system integrates IoT-based environmental sensing, Temporal Fusion Transformer-based multivariate forecasting, knowledge distillation, edge-deployed Bi-LSTM inference, and Mamdani fuzzy logic control within a unified IAQ management architecture. A composite Comfort Risk Index is introduced to combine environmental parameters and occupant discomfort feedback into a single adaptive control indicator. Experimental evaluation under varying indoor conditions demonstrated strong forecasting performance, with prediction accuracies reaching 96.3% for CO₂ and 95.7% for PM_2.5 prediction, while reducing inference latency from 575 ms to 295 ms. Comparative analysis against baseline threshold-based control strategies further indicated improved comfort stability, smoother actuator behavior, and reduced estimated actuator operating intensity during deployment. The proposed framework also demonstrated resilient operation under simulated sensor-failure conditions while maintaining low computational overhead suitable for resource-constrained IoT-edge environments. Overall, the results indicate that combining lightweight deep learning models with interpretable fuzzy control can provide an effective, scalable, and energy-aware solution for intelligent real-time IAQ optimization in smart indoor environments. Full article

To address the problems of closed-loop task organization, strong corridor constraints, and path failure after local disturbances in unmanned aerial vehicle (UAV) inspection of gas-insulated switchgear (GIS) rooms, this paper proposes a topology-and-corridor-guided bias-suppressed D* (TCG-BS-D*) method for closed-loop three-dimensional (3D) path planning and local replanning. The proposed method constructs a structured guidance model based on the inspection-corridor topology, generates local 3D path segments according to a predetermined inspection sequence, and forms a nominal closed-loop inspection path through bias suppression and path regularization. Meanwhile, for local maintenance blockage and dynamic disturbance scenarios, an alternative local replanning strategy is applied to the affected path segments. Simulation results show that, under the static closed-loop inspection condition, the proposed method achieves a total path length of 700.22 m, a total inspection time of 269.32 s, an average safety clearance of 8.18 m, 37 large-angle turns, a corridor adherence rate of 80.73%, and a task completion rate of 100%, showing superior performance in inspection efficiency, safety margin, trajectory regularity, and corridor consistency. Under the local blockage condition, the replanned path introduces path-length and time increments of 71.29 m and 25.88 s, respectively, while maintaining the minimum safety clearance at 1.52 m and increasing the corridor adherence rate to 83.91%. Under dynamic disturbance conditions, the minimum dynamic safety clearance is improved from −2.71 m to 17.84 m, effectively eliminating the local dynamic collision risk. The results demonstrate that the proposed method can balance closed-loop path-generation efficiency, corridor-structure consistency, safety margin, and adaptability to local disturbances, providing an effective solution for UAV inspection path planning in GIS rooms. Full article

Loess slopes are prone to rapid infiltration, surface erosion, and shallow instability under intense rainfall, highlighting the need for eco-friendly shallow protection methods with enhanced anti-seepage and erosion resistance. To improve the applicability of microbially induced calcite precipitation (MICP) in loess slope protection, this study proposes a combined MICP–sesbania gum (SG) modification method. Permeability tests, surface hardness tests, and indoor artificial rainfall model tests were conducted to systematically evaluate its effects on seepage control and the erosion resistance of loess slopes. The results show that calcium chloride provides a stronger permeability-reducing effect than calcium acetate. Compared with the MICP-only treatment, the combined MICP-SG treatment significantly reduces the permeability coefficient and increases surface hardness. Based on the overall modification performance, a cementation solution concentration of 1.0 mol/L and a curing time of 7 d were selected as suitable treatment parameters. Rainfall model tests further demonstrate that the combined treatment delays erosion failure, reduces infiltration rate and soil loss, and suppresses wetting front migration and internal water content response. These findings indicate that MICP combined with SG can effectively improve the anti-seepage, erosion resistance and surface stability of shallow loess slopes, providing experimental support for eco-friendly shallow slope protection in loess regions. Full article

Background: Precise intraoperative localisation of small colorectal tumours during laparoscopic surgery remains challenging due to absent tactile feedback and subserosal tumour location. Current standard methods, particularly India ink tattooing, demonstrate 15–30% failure rates for lesions less than 10 mm, leading to prolonged operative times, incomplete resections, and re-operations. Multiple emerging technologies promise improved localisation, yet comparative evidence remains fragmented. Objective: To map and characterise the current landscape of intraoperative marking and identification technologies for small colorectal tumour localisation during laparoscopic surgery, with emphasis on radiofrequency-based methods and alternative approaches, and to identify evidence gaps guiding future research. Methods: Following PRISMA-ScR guidelines, we systematically searched PubMed, Web of Science, and Scopus databases from January 2000 through December 2025 for studies evaluating tumour localisation technologies in colorectal cancer surgery, including primary tumour localisation during laparoscopic colectomy and localisation of colorectal liver metastases during hepatic surgery, or transferable anatomical applications with documented translational potential to colorectal surgery. Two independent reviewers screened all records, with discrepancies resolved through discussion and a third senior reviewer consulted for unresolved disagreements; data were extracted on technical performance, safety, feasibility, cost-effectiveness, usability, innovation potential, and evidence quality. Results: We included 89 studies comprising 18 colorectal-specific articles and 71 transferable/GI-adjacent studies. Detection success rates ranged from 71% to 100% across modalities. Near-infrared fluorescence with indocyanine green demonstrated the strongest clinical evidence with 75–100% detection across eight colorectal studies encompassing 2134 procedures and seamless workflow integration. Radiofrequency identification systems achieved 91.9–99% detection in feasibility studies with promising tissue penetration of 15–35 mm but limited colorectal validation. Electromagnetic navigation excelled in rigid organs with 85–98% success but showed degraded performance in mobile bowel at 71–75%. Critical evidence gaps included absent head-to-head comparative trials, non-standardised outcome metrics limiting cross-study comparability, and limited long-term safety data with only 14 studies providing follow-up exceeding six months. Conclusions: ICG fluorescence represents the most clinically mature technology identified, representing a priority candidate for colorectal-specific validation in challenging localisation scenarios. RFID systems demonstrate promising characteristics justifying prioritised research investment through adequately powered comparative trials. Future research must emphasise consortium-based comparative effectiveness studies, standardised outcome metrics, and integration with robotic and AI-assisted surgical platforms to accelerate clinical translation. Full article

This study presents a comprehensive symmetry-breaking analysis framework for a twelve-legged Jansen walking robot, integrating finite element analysis (FEA) with adaptive neuro-fuzzy inference system (ANFIS) surrogate modeling. A systematic dataset of 210 cases was generated by combining 21 single- and multi-leg failure scenarios across 10 load levels (20–200 N) on the PLA-based 3D-printed prototype. Two novel dimensionless metrics are introduced: the Resilience Index (RI), quantifying the proportional stress increase relative to the baseline, and the Asymmetry Index (AI), measuring leg-reaction force distribution imbalance. Results identify a clear fault-tolerance threshold between two- and four-leg failures: single-leg failures remain at LOW risk (RI < 0.20), while three-leg asymmetric failures (S18) reach CRITICAL level (RI = 1.13, ~97% of PLA yield strength). A hybrid machine learning framework is proposed, applying ANFIS to maximum stress (R² = 0.817) and safety factor (R² = 0.936) predictions, while reserving FEA tables for bimodal outputs. The ANFIS surrogate achieves approximately 10⁶× speedup over FEA (262.6 μs vs. 5–8 min), enabling real-time fault diagnosis and digital twin applications. The framework is generalizable to other multi-legged robotic systems requiring fault-tolerance evaluation. Full article

Three-dimensional (3D) endothelium–stromal co-cultures were established using human endometrial cells from biopsy of healthy women (n = 13) and serum samples from both healthy and endometriotic women (n = 5). For 3D construction, stromal cells were mixed with extracellular matrix components, followed by endothelial cell seeding. Morphological analysis confirmed the organization of tissue-like structures. Immunofluorescence and flow cytometry verified the expression of specific stromal and endothelial markers (Cytokeratin, Vimentin, Insulin-like growth factor-binding protein 1, and von Willebrand factor). Cell viability and proliferation increased over time, with minimal cell death. To test functional responsiveness, these co-cultures were exposed to inflammatory serum from endometriotic patients. After 48 h, cytometric bead array showed elevated levels of IL-1β, IL-6, and IL-8 in cultures treated with inflammatory serum, indicating preserved functional activity and responsiveness. By allowing detailed investigation of functional endometrial states within a physiologically relevant cellular network, this approach provides a valuable organoid-like tool to explore conditions such as implantation failure and infertility and to study the cellular interactions underlying reproductive pathologies. Full article