Search Results (13)

Stellar radiation simulation is critical in the space industry; however, with the current simulation methods, only a single color temperature and magnitude can be modulated at a time. Furthermore, star sensors rely on star observation tests for accurate calibration; this seriously restricts their development. This paper presents a novel star spectral information multi-partition mapping simulation method to closely simulate real sky star map information, thus replacing non-scenario-specific field stargazing experiments. First, using the stellar spectral simulation principle, a multi-partition mapping principle based on a digital micro-mirror device is proposed, and the theoretical basis of sub-region division is provided. Second, multi-component mapping simulation of stellar spectral information is expounded, and a general architecture for the same based on a double-prism symmetry structure is presented. Next, the influence of peak spectral half-peak width and peak interval on spectral simulation accuracy is analyzed, and a pre-collimated beam expansion system, multi-dimensional slit, and spectral splitting system are designed accordingly. Finally, a test platform is set up, and single-region simulation results and multi-region consistency experiments are conducted to verify the feasibility of the proposed method. Our method can realize high-precision simulation and independently control the output of various color temperatures and magnitudes. It provides a theoretical and technical basis for the development of star sensor ground calibration tests and space target detection light environment simulation. Full article

This study aimed to address the unexplored relaxing effects of stargazing with different night sky darknesses in a planetarium by conducting an experiment to investigate the physiological effects of the relaxation/stress state on brain and autonomic nervous system activity, as well as the psychological healing effects. Five healthy young women participated in our experiment. We conducted physiological measurements of oxygenated hemoglobin (OxyHb) concentration in the left and right prefrontal cortices by near-infrared spectroscopy, heart rate variability as a measure of the relaxation/stress state, and a psychological assessment of healing on an 11-point Likert scale. We used 9 types of stimuli: 6-star image stimuli that imitated dark star fields (low light pollution) to bright night sky (high light pollution), and movie stimuli that were viewed daily. The results showed that (1) visual stimulation with images of dark night sky significantly reduced the concentration of OxyHb in the right prefrontal cortex and (2) the psychological rating of healing was significantly higher compared to bright night sky. The results of this study will help solve the problems of the mental and physical effects of light pollution on astronomical observations and the reproduction of star images in planetariums. Full article

A neural network was developed using the Multilayer Perceptron (MLP) model to predict the darkness value of the night sky in rural areas. For data collection, a photometer was placed in three different rural locations in the province of Cáceres, Spain, recording darkness values over a period of 23 months. The recorded data were processed, debugged, and used as a training set (75%) and validation set (25%) in the development of an MLP capable of predicting the darkness level for a given date. The network had a single hidden layer of 10 neurons and hyperbolic activation function, obtaining a coefficient of determination (R²) of 0.85 and a mean absolute percentage error (MAPE) of 6.8%. The developed model could be employed in unpopulated rural areas for the promotion of sustainable astronomical tourism. Full article

Pollen grains, with their resilient sporopollenin exine and defined morphologies, have been explored as bio-templates for the synthesis of calcium phosphate minerals, particularly hydroxyapatite (HAp) and β-tricalcium phosphate (TCP). Various pollen morphologies from different plant species (black alder, dandelion, lamb’s quarters, ragweed, and stargazer lily) were evaluated. Pollen grains underwent acid washing to remove allergenic material and facilitate subsequent calcification. Ragweed and lamb’s quarter pollen grains were chosen as templates for calcium phosphate salts deposition due to their distinct morphologies. The calcification process yielded well-defined spherical hollow particles. The washing step, intended to reduce the protein content, did not significantly affect the final product; thus, justifying the removal of this low-yield step from the synthesis process. Characterisation techniques, including X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermal gravimetric analysis, confirmed the successful calcification of pollen-derived materials, revealing that calcified grains were principally composed of calcium deficient HAp. After calcination, biphasic calcium phosphate composed of HAp and TPC was obtained. This study demonstrated the feasibility of using pollen grains as green and sustainable bio-templates for synthesizing biomaterials with controlled morphology, showcasing their potential in biomedical applications such as drug delivery and bone regeneration. Full article

Several factors affect the visibility of the night sky, most significantly artificial light at night (ALAN), meteorological conditions and Moon illumination. There are few studies that analyse the effect of meteorological conditions and Moon illumination, especially in rural areas (where the ALAN level is lower). An analysis of these variables could be relevant for sky observation, especially for astronomical observatories, usually located in rural areas with low ALAN. Knowledge of the relevant variables in the observation allows for the correct planning of the observation. The observer can consult meteorological agencies for forecasts of these variables, allowing him to know in advance whether the observation will be carried out under optimal conditions. In this study, a photometer and a weather station were installed in various municipalities located in rural areas of south-western Spain. This equipment was also installed in the city of Badajoz (urban area with high ALAN). These devices carried out simultaneous measurements of night sky darkness (NSB) and meteorological conditions for a period of approximately 6 months. A statistical analysis of the recorded data was carried out. Only the Moon illumination was slightly correlated with NSB in both cases (−0.3 in rural areas and −0.35 in urban areas). Sky temperature only proved a correlation with NSB in the urban area (−0.41). The correlations indicated are significant at the 0.01 level. The results obtained in the urban area were confirmed by a second analysis using meteorological data provided by a meteorological agency, obtaining similar results. A web application was developed that allows for real-time consultation of NSB and meteorological data for each area, which can help observe the starry sky. Globally, the results obtained in this study could help in the planning of stargazing in both urban and rural areas, allowing one to know in advance if weather conditions would affect the perception capacity. Full article

Currently, there are concerns about the significant increase in the level of night-time light pollution, which has become more dramatic in recent years. This causes several environmental problems and makes it impossible to observe the starry night sky, especially in rural areas where observatories are often located. Incorrect orientation and arrangement of lighting are often responsible for this pollution. This study quantified the level of interference of lighting parameters in the night sky. The influence of other environmental factors which may interfere with observation was also evaluated. A predictive model was developed to determine the level of darkness in rural areas. It was concluded that the distance from the emission point to the observation site is critical for sky observation. A series of guidelines were proposed for designing the lighting around observatories, which could help reduce light pollution and increase the stars’ perception. The conclusions and guidelines obtained could also be applied to designing the lighting in other areas, such as protected natural areas, historical monuments, urban lighting, and computer tools used for lighting. Globally, the results obtained in this study could help to reduce the level of night-time light pollution in rural areas, leading to improvements in the environment and in the observation of the night sky. This finding is of great relevance for astronomical observatories, which are spread around the world in strategic positions for sky observation, usually in rural areas. Full article

Childhood absence epilepsy seizures arise in the cortico-thalamocortical network due to multiple cellular and molecular mechanisms, which are still under investigation. Understanding the precise mechanisms is imperative given that treatment fails in ~30% of patients while adverse neurological sequelae remain common. Impaired GABAergic neurotransmission is commonly reported in research models investigating these mechanisms. Recently, we reported a region-specific reduction in the whole-tissue and synaptic GABA_A receptor (GABA_AR) α1 subunit and an increase in whole-tissue GAD65 in the primary somatosensory cortex (SoCx) of the adult epileptic stargazer mouse compared with its non-epileptic (NE) littermate. The current study investigated whether these changes occurred prior to the onset of seizures on postnatal days (PN) 17–18, suggesting a causative role. Synaptic and cytosolic fractions were biochemically isolated from primary SoCx lysates followed by semiquantitative Western blot analyses for GABA_AR α1 and GAD65. We found no significant changes in synaptic GABA_AR α1 and cytosolic GAD65 in the primary SoCx of the stargazer mice at the critical developmental stages of PN 7–9, 13–15, and 17–18. This indicates that altered levels of GABA_AR α1 and GAD65 in adult mice do not directly contribute to the initial onset of absence seizures but are a later consequence of seizure activity. Full article

Absence seizures are hyperexcitations within the cortico-thalamocortical (CTC) network, however the underlying causative mechanisms at the cellular and molecular level are still being elucidated and appear to be multifactorial. Dysfunctional feed-forward inhibition (FFI) is implicated as one cause of absence seizures. Previously, we reported altered excitation onto parvalbumin-positive (PV⁺) interneurons in the CTC network of the stargazer mouse model of absence epilepsy. In addition, downstream changes in GABAergic neurotransmission have also been identified in this model. Our current study assessed whether dysfunctional FFI affects GABA_A receptor (GABA_AR) subunit expression in the stargazer primary somatosensory cortex (SoCx). Global tissue expression of GABA_AR subunits α1, α3, α4, α5, β2, β3, γ2 and δ were assessed using Western blotting (WB), while biochemically isolated subcellular fractions were assessed for the α and δ subunits. We found significant reductions in tissue and synaptic expression of GABA_AR α1, 18% and 12.2%, respectively. However, immunogold-cytochemistry electron microscopy (ICC-EM), conducted to assess GABA_AR α1 specifically at synapses between PV⁺ interneurons and their targets, showed no significant difference. These data demonstrate a loss of phasic GABA_AR α1, indicating altered GABAergic inhibition which, coupled with dysfunctional FFI, could be one mechanism contributing to the generation or maintenance of absence seizures. Full article

Before the COVID-19 pandemic, the World Tourism Organization (UNWTO) stated that “sun and beach” tourist destinations needed to direct more resources towards innovation, sustainability and accessibility. This is related to the crisis that many sun and beach tourist destinations are experiencing. In the Canary Islands, changes to legislation together with urban and tourist products have been made in accordance with UNWTO proposals. For many years the island of La Palma has been offering tourists hiking, stargazing and volcano tourism besides “sun and beach holidays”. However, the 2021 eruption of Tajogaite, Cumbre Vieja aggravated the island’s tourism crisis and caused very negative effects on the economy. This work identifies, selects and characterizes places of interest for geotourism development in the two largest population centers (Santa Cruz de La Palma and Los Llanos de Aridane). Santa Cruz de La Palma has 20 points of interest; Los Llanos de Aridane has 14. All sites contribute to showcasing the diversity of the natural and cultural volcanic and non-volcanic heritage of the regions. The geotourism product in La Palma is relatively new and exploits the topography present, including natural outcrops (cinder cones, lava fields, ravines, cliffs, sedimentary deposits or beaches), and also the cultural heritage (religious and civil architecture, streets or town planning, planes). These proposals for urban geotourism take advantage of the volcanic geoheritage of La Palma and increase the breadth and quality of tourism on offer. Full article

Stargazing tourism is an expanding market niche that requires the development of territorial resources for its implementation and attraction. This paper’s objective is to investigate the preferences and willingness to pay of tourists for the development of strategic land resources for stargazing tourism activities. The field work was conducted on the island of La Palma (Canary Islands), which is promoting the territorial development of infrastructures for stargazing tourism. A random sample of 734 tourists were interviewed in person on-site in December 2019 following the methodology discrete choice experiments that enabled an estimation of tourists’ preferences and willingness to pay for the implementation of key land resources for stargazing. The data are modeled using a latent class model that allows for the consideration of heterogeneous preferences. The results show that there are three groups of tourists with different preferences for land resources of stargazing observation. These segments are respectively related to the interests in culture, active, and astronomic tourism. Those tourists in the active stargazing segment share the largest proportion of the market and favor the implementation of facilities that allow the combination of active tourism with stargazing. The results are useful for land product development and territorial strategies aimed at positioning destinations in the identified demand niches of stargazing tourism. Full article

Absence seizures are associated with generalised synchronous 2.5–4 Hz spike-wave discharges causing brief and sudden alteration of awareness during childhood, which is known as childhood absence epilepsy (CAE). CAE is also associated with impaired learning, psychosocial challenges, and physical danger. Absence seizures arise from disturbances within the cortico-thalamocortical (CTC) network, including dysfunctional feed-forward inhibition (FFI); however, the precise mechanisms remain unclear. In epileptic stargazers, a genetic mouse model of CAE with chronic seizures, levels of γ-aminobutyric acid (GABA), and expression of GABA receptors are altered within the CTC network, implicating altered GABAergic transmission in absence seizures. However, the expression of GABA synthesising enzymes (GAD65 and GAD67) and GABA transporters (GAT-1 and 3) have not yet been characterised within absence seizure models. We found a specific upregulation of GAD65 in the somatosensory cortex but not the thalamus of epileptic stargazer mice. No differences were detected in GAD67 and GAT-3 levels in the thalamus or somatosensory cortex. Then, we assessed if GAD65 upregulation also occurred in Gi-DREADD mice exhibiting acute absence seizures, but we found no change in the expression profiles of GAD65/67 or GAT-3. Thus, the upregulation of GAD65 in stargazers may be a compensatory mechanism in response to long-term dysfunctional FFI and chronic absence seizures. Full article

With the tremendous advancements in genome sequencing technology in the field of pharmacogenomics, data have to be made accessible to be more efficiently utilized by broader clinical disciplines. Physicians who require the drug–genome interactome information, have been challenged by the complicated pharmacogenomic star-based classification system. We present here an end-to-end web-based pharmacogenomics tool, PharmaKU, which has a comprehensive easy-to-use interface. PharmaKU can help to overcome several hurdles posed by previous pharmacogenomics tools, including input in hg38 format only, while hg19/GRCh37 is now the most popular reference genome assembly among clinicians and geneticists, as well as the lack of clinical recommendations and other pertinent dosage-related information. This tool extracts genetic variants from nine well-annotated pharmacogenes (for which diplotype to phenotype information is available) from whole genome variant files and uses Stargazer software to assign diplotypes and apply prescribing recommendations from pharmacogenomic resources. The tool is wrapped with a user-friendly web interface, which allows for choosing hg19 or hg38 as the reference genome version and reports results as a comprehensive PDF document. PharmaKU is anticipated to enable bench to bedside implementation of pharmacogenomics knowledge by bringing precision medicine closer to a clinical reality. Full article

This autumn, 95 scientists and students from the Rocky Mountain area, along with invited speakers from Colorado, California, Montana, Florida, Louisiana, New York, Maryland, and India, attended the 19th annual meeting of the Rocky Mountain Virology Association that was held at the Colorado State University Mountain Campus located in the Rocky Mountains. The two-day gathering featured 30 talks and 13 posters—all of which focused on specific areas of current virology and prion protein research. The keynote presentation reviewed new tools for microbial discovery and diagnostics. This timely discussion described the opportunities new investigators have to expand the field of microbiology into chronic and acute diseases, the pitfalls of sensitive molecular methods for pathogen discovery, and ways in which microbiology help us understand disruptions in the social fabric that pose pandemic threats at least as real as Ebola or influenza. Other areas of interest included host factors that influence virus replication, in-depth analysis of virus transcription and its effect on host gene expression, and multiple discussions of virus pathology, epidemiology as well as new avenues of diagnosis and treatment. The meeting was held at the peak of fall Aspen colors, surrounded by five mountains >11,000 ft (3.3 km), where the secluded campus provided the ideal setting for extended discussions, outdoor exercise and stargazing. On behalf of the Rocky Mountain Virology Association, this report summarizes 43 selected presentations. Full article