Search Results (28)

In their evolution from conservation places of isolated resources to social spaces in service of communities, museums are increasingly called to express their representative character towards their originating territories. Furthermore, the museum’s mission has been gradually enriched with new, more complex functions towards local communities, through a call to actively confront with their contexts, a trend the recent pandemic events have only accelerated. Cultural heritage, with museums at the forefront, as an acknowledged driver of socioeconomic development, has manifold impacts on territories, which have been identified and investigated in the literature, often from a potential perspective. Given the strong territorial component of the museum heritage connection with its reference context, this study aims to investigate the contribution that mapping and GIS technologies, traditionally employed at the scale of single museum buildings, can offer in assessing the actual “living” presence of museums in the local socioeconomic and productive fabric, through the relationships with other reference entities in the territories and their outreach. Taking a sample with a marked nature of spatially ‘distributed’ heritage (archaeologic museums of the Puglia region, South Italy) as a case study, the article presents a mapped representation of a questionnaire-based survey of museums’ recent territorial relationships. The twofold outcomes of the study show, on the one hand, that the investigated sample still experiences criticalities in fully expressing and communicating its potentialities and values in the current scenario and, on the other hand, that mapping technologies can concretely contribute to the museum sector’s innovation by examining its territorial relationships, in line with the current conceptual evolution, also with possible implications on museums’ quality assessment. Full article

The COVID-19 pandemic highlighted the role of urban parks as green spaces in mitigating social isolation and supporting public mental health. Research in this area is limited due to the lack of large-scale datasets. Moreover, timely studies are indeed necessary under pandemic conditions. This study employs quantitative methods to analyze the temporal and spatial changes in social interaction in 160 urban parks before, during, and after the COVID-19 pandemic, and assesses their correlation with the built environment. Social media data from the Dianping platform were collected for this purpose. A two-step analytical approach was employed: first, machine learning-based keyword analysis identified review data related to social interaction, leading to the construction of two indicators: social interaction intensity and social interaction recovery rate. Second, we applied regression models to explore the correlation between the two indicators in urban parks and 18 characteristics of the built environment. The built environment characteristics associated with social interaction intensity varied across different periods, with seven factors, including natural landscapes, perceptual experience, building density, and road intersections, showing significant correlations with the recovery of social interaction capabilities in the post-pandemic era. Based on these findings, it is recommended that urban planners consider integrating more flexible design element, such as adding greenery and enriching the audio-visual experience for visitors. Furthermore, enhancing the quality and accessibility of park amenities can foster social interaction, thereby contributing to public health resilience in future crises. This research recommends that urban park design should not only support communities’ immediate needs but also prepare for unforeseen challenges. Full article

This article addresses the inherently relational nature of musical agency, drawing upon interdisciplinary research. It argues that music does not exist in isolation but within social and emotional contexts shaped by a network of relationships among musicians. These interactions create a collaborative space that transcends mere technical execution, fostering a collective experience enriched by shared sensitivity and emotional engagement. Consequently, musical practice, whether compositional or performative, entails a moral responsibility, particularly challenging the perspectives of Levinas; Bauman; and Wilde, who traditionally separated art from ethics. As outlined in Nielsen and Cobussen’s work “music contributes to a better understanding of one’s place within the world, and thus, to an ethical sensibility”, emphasizing how musical practice cultivates ethical awareness through its relational nature. Music is thus conceived as a moral endeavor, where care extends not only to the music itself but also to the individuals involved in its creation and performance. Moreover, this moral responsibility extends to future generations, as musical tradition is conceived as a temporal bridge linking the past, the present, and the future. The tradition is composed of individuals actively engaged in the practices that shape the tradition or traditions. Musicians bear an intergenerational responsibility toward those who will inherit and reinterpret current practices—a responsibility not grounded in direct reciprocity, but in what Randall describes as “conceptual ties”. The continuity of musical tradition and its aesthetic value depend on the care and responsibility each generation shows toward both the participants and the evolving cultural products of this process. Thus, the discussion elucidates the ethical dimensions of musical agency and practice, particularly in Western classical music, and highlights how our obligations to future generations are intrinsic to the practice itself, thereby contributing to broader debates on intergenerational care ethics. Full article

Joseph Ratzinger points to the dialogical nature of the human being. Indeed, the human is by nature called to live in relationships, and for him/her social life is a natural environment of existence. This need, which humans discover within themselves, has its source in Communio Trinitatis, the profound communion of the three Divine Persons. In essence, God is not a loner but an eternal dialogue of love. As evidence of this, He created the human being in His image and likeness. The human’s role model lives in a relationship of love. Hence, the individual also discovers a deep need within him/herself for interpersonal communication. In this respect, it is healing for a person to live in a relationship. Firstly, because the dialogue of faith with God is true healing and salvation for the human being. Secondly, relationships with other humans also have an enriching impact on their personality. However, J. Ratzinger stresses that isolation alienates people and even leads to illness or death. Meanwhile, a living relationship with God and other people transforms the human person and ensures personal growth. Full article

The global health emergency generated by the COVID-19 pandemic (caused by the SARS-CoV-2 virus) led to the implementation of extraordinary measures such as confinement and isolation in many countries to mitigate the spread of the virus. (1) This study analyzes the lifestyles and academic and perceived stresses of university students of health sciences during the period of online learning due to the COVID-19 pandemic. The relationship between lifestyles and academic stress was examined. (2) A parallel mixed-method convergent study was conducted, with a correlational non-experimental design. Quantitative and qualitative data were collected and analyzed in parallel, with parametric and nonparametric testing for quantitative data and Miles and Huberman’s approach to qualitative analysis. The qualitative findings complemented the quantitative results. The number of students who participated in this study was 2734, from six programs in health, nursing, medicine, clinical laboratory, physiotherapy, dentistry, and clinical psychology at the University of Chimborazo, Ecuador. (3) Overall, the health science students had “Unhealthy or health-compromising lifestyles”, medical students being the ones who have healthier lifestyles. However, more than 80% experienced and perceived stress during the period of online learning and social isolation due to the pandemic, women being the ones who experienced it at a higher level. (4) The online learning modality during the COVID-19 pandemic modified lifestyles and generated stress in health science students, due to changes in daily routines, sedentary lifestyle, and stress, as a result of social isolation. Therefore, the students prefer face-to-face teaching, perceived as enabling more enriching interactions with their teachers and peers and the opportunity to develop essential practical skills in their health practice. Full article

International development organisations have improved billions of human lives in the Global South. However, in both their projects and advice to governments, most of these organisations neglect animal welfare. This blindspot matters. Poor welfare standards risk the organisation’s reputation, particularly with donors; they reduce livestock lifespans and productivity, harming recipients; and they cause animals unnecessary pain and suffering. Here, we set out animal welfare guidelines for international development organisations. They were developed through extensive stakeholder engagement with organisations, donors, and recipients, especially in Africa. To comprehensively cover animal welfare, the guidelines encompass governance structure within the organisation, staff training, standard operating procedures, water, food, housing, social isolation, enrichment, drainage and waste disposal, disease, invasive procedures, transport, slaughter, breeds, record-keeping, and monitoring and evaluation of success. We urge international development organisations to adopt and institutionalise these guidelines, so they promote good animal welfare. Full article

The development of sustainable smart cities (SSCs) is pivotal for contemporary urban expansion, as highlighted by numerous international frameworks and scholarly studies. This study focused on Saudi Arabia to identify and assess the key challenges impeding the evolution of intelligent and sustainable urban environments. By categorizing and hierarchically analyzing these impediments, the research isolates the most significant barriers to SSC advancement. A total of 18 obstacles were identified, organized into four categories, and reviewed using existing scholarly literature. Semi-structured interviews were conducted with stakeholders engaged in executing SSC initiatives, enriching the research from a practical perspective. Additionally, a survey ranked these barriers, revealing that social and economic factors pose the most significant challenges, followed by governance and legal, technology, and environment. The findings of this study offer critical insights for policymakers and governments to mitigate the barriers to SSC development efforts. Full article

Isolated water and energy microgrids (IWEMGs) serve as vital solutions for enhancing the well-being of remote and rural communities, particularly in areas where water and energy resources are scarce. This has spurred research into the interdependence between the water and energy sectors (water–energy nexus), a field that has grown in response to technological advancements. Through a systematic optimization framework, this review critically evaluates the integration of various technologies within IWEMGs, encompassing infrastructure, management, and strategic planning, while considering economic and social impacts. IWEMGs incorporate diverse technologies for the infrastructure, management, and strategic planning of water and energy resources, integrating economic and social considerations to inform decisions that affect both immediate and long-term sustainability and reliability. This article presents an exhaustive review of the literature on IWEMG management, employing an approach that synthesizes existing studies to enhance the understanding of strategic IWEMG management and planning. It introduces a structured taxonomy for organizing research trends and tackling unresolved challenges within the field. Notably, the review identifies critical gaps, such as the lack of comprehensive data on water demand in isolated locations, and underscores the emerging role of game theory and machine learning in enriching IWEMG management frameworks. Ultimately, this review outlines essential indicators for forthcoming research, focusing on the optimization, management, and strategic planning of IWEMG resources and infrastructure, thereby setting a direction for future technological and methodological advancements in the field. Full article

Individuals with psychosocial stress often experience an exaggerated response to air pollutants. Ozone (O₃) exposure has been associated with the activation of the neuroendocrine stress-response system. We hypothesized that preexistent mild chronic stress plus social isolation (CS), or social isolation (SI) alone, would exacerbate the acute effects of O₃ exposure on the circulating adrenal-derived stress hormones, and the expression of the genes regulating glucocorticoid stress signaling via an altered stress adaptation in a brain-region-specific manner. Male Wistar–Kyoto rats (5 weeks old) were socially isolated, plus were subjected to either CS (noise, confinement, fear, uncomfortable living, hectic activity, and single housing), SI (single housing only, restricted handling and no enrichment) or no stress (NS; double housing, frequent handling and enrichment provided) for 8 weeks. The rats were then exposed to either air or O₃ (0.8 ppm for 4 h), and the samples were collected immediately after. The indicators of sympathetic and hypothalamic–pituitary axis (HPA) activation (i.e., epinephrine, corticosterone, and lymphopenia) increased with O₃ exposure, but there were no effects from CS or SI, except for the depletion of serum BDNF. CS and SI revealed small changes in brain-region-specific glucocorticoid-signaling-associated markers of gene expression in the air-exposed rats (hypothalamic Nr3c1, Nr3c2 Hsp90aa1, Hspa4 and Cnr1 inhibition in SI; hippocampal HSP90aa1 increase in SI; and inhibition of the bed nucleus of the stria terminalis (BNST) Cnr1 in CS). Gene expression across all brain regions was altered by O₃, reflective of glucocorticoid signaling effects, such as Fkbp5 in NS, CS and SI. The SI effects on Fkbp5 were greatest for SI in BNST. O₃ increased Cnr2 expression in the hypothalamus and olfactory bulbs of the NS and SI groups. O_3, in all stress conditions, generally inhibited the expression of Nr3c1 in all brain regions, Nr3c2 in the hippocampus and hypothalamus and Bdnf in the hippocampus. SI, in general, showed slightly greater O₃-induced changes when compared to NS and CS. Serum metabolomics revealed increased sphingomyelins in the air-exposed SI and O₃-exposed NS, with underlying SI dampening some of the O₃-induced changes. These results suggest a potential link between preexistent SI and acute O₃-induced increases in the circulating adrenal-derived stress hormones and brain-region-specific gene expression changes in glucocorticoid signaling, which may partly underlie the stress dynamic in those with long-term SI. Full article

Alzheimer’s disease (AD)—the most common cause of dementia in the elderly—is characterized by progressive memory loss and β-amyloid protein (Aβ) accumulation in the brain. Recently, loneliness was found to be a high risk factor for AD, and social isolation has become a major cause of AD. AD. Oxytocin (OXT), the main hormone involved in social bonding, has been implicated in social interactions, notably in building trust and relationships. Moreover, social isolation or social enrichment modulates the activation of neurons related to OXT. Recently, we reported that OXT reverses learning and memory impairment in AD animal models. Based on the limited number of studies currently available, OXT might be a therapeutic target for AD. Further studies are necessary in order to better understand the role of oxytocin in AD. In this review, we described the relationships between OXT, AD, and social interaction. Full article

Loneliness and social isolation are detrimental to mental health and may lead to cognitive impairment and neurodegeneration. Although several molecular signatures of loneliness have been identified, the molecular mechanisms by which loneliness impacts the brain remain elusive. Here, we performed a bioinformatics approach to untangle the molecular underpinnings associated with loneliness. Co-expression network analysis identified molecular ‘switches’ responsible for dramatic transcriptional changes in the nucleus accumbens of individuals with known loneliness. Loneliness-related switch genes were enriched in cell cycle, cancer, TGF-β, FOXO, and PI3K-AKT signaling pathways. Analysis stratified by sex identified switch genes in males with chronic loneliness. Male-specific switch genes were enriched in infection, innate immunity, and cancer-related pathways. Correlation analysis revealed that loneliness-related switch genes significantly overlapped with 82% and 68% of human studies on Alzheimer’s (AD) and Parkinson’s diseases (PD), respectively, in gene expression databases. Loneliness-related switch genes, BCAM, NECTIN2, NPAS3, RBM38, PELI1, DPP10, and ASGR2, have been identified as genetic risk factors for AD. Likewise, switch genes HLA-DRB5, ALDOA, and GPNMB are known genetic loci in PD. Similarly, loneliness-related switch genes overlapped in 70% and 64% of human studies on major depressive disorder and schizophrenia, respectively. Nine switch genes, HLA-DRB5, ARHGAP15, COL4A1, RBM38, DMD, LGALS3BP, WSCD2, CYTH4, and CNTRL, overlapped with known genetic variants in depression. Seven switch genes, NPAS3, ARHGAP15, LGALS3BP, DPP10, SMYD3, CPXCR1, and HLA-DRB5 were associated with known risk factors for schizophrenia. Collectively, we identified molecular determinants of loneliness and dysregulated pathways in the brain of non-demented adults. The association of switch genes with known risk factors for neuropsychiatric and neurodegenerative diseases provides a molecular explanation for the observed prevalence of these diseases among lonely individuals. Full article

While advanced reproductive technologies have attained remarkable increases in sophistication, success, and availability since the 1980s, clinicians always meet a therapeutic impasse when the ovarian reserve reaches exhaustion. Irrespective of fertility aspirations, the decline in and eventual collapse of ovarian estrogen output means that menopause arrives with tremendous physiologic changes and reduced overall productivity. Because more women are gaining in longevity or delaying the age at pregnancy, the number of affected patients has never been larger. As concerns regarding standard hormone replacement therapy and the limitations of IVF are confronted, a workable path to enable primordial germ cell recruitment and de novo oocyte development would be welcome. Proof-of-concept case reports and clinical studies on autologous activated platelet-rich plasma (PRP) or its condensed cytokine derivatives suggest a way to facilitate these goals. However, ovarian PRP faces vexing challenges that place ‘ovarian rejuvenation’ under caution as it enters this therapeutic space. Here, we review key features of experimental human ovarian stem cell isolation/handling and reaffirm the need to harmonize laboratory protocols. Recognizing the regenerative science borrowed from other disciplines, specimen centrifugation, platelet processing, and condensed plasma cytokine enrichment are highlighted here. As the refinement of this rejuvenation approach would promise to reprogram adult ovarian physiology, the disruption of established treatment paradigms for infertility, menopause, and perhaps overall women’s health seems likely. Emerging roles in reproductive biology and clinical practice are thus placed in a broader social and demographic context. Full article

Prenatal maternal stress is linked to adverse pregnancy and infant outcomes, including shortened gestation lengths, low birth weights, cardio-metabolic dysfunction, and cognitive and behavioural problems. Stress disrupts the homeostatic milieu of pregnancy by altering inflammatory and neuroendocrine mediators. These stress-induced phenotypic changes can be passed on to the offspring epigenetically. We investigated the effects of gestational chronic variable stress (CVS) in rats using restraint and social isolation stress in the parental F0 generation and its transgenerational transmission across three generations of female offspring (F1–F3). A subset of F1 rats was housed in an enriched environment (EE) to mitigate the adverse effects of CVS. We found that CVS is transmitted across generations and induces inflammatory changes in the uterus. CVS did not alter any gestational lengths or birth weights. However, inflammatory and endocrine markers changed in the uterine tissues of stressed mothers and their offspring, suggesting that stress is transgenerationally transmitted. The F2 offspring reared in EE had increased birth weights, but their uterine gene expression patterns remained comparable to those of stressed animals. Thus, ancestral CVS induced changes transgenerationally in fetal programming of uterine stress markers over three generations of offspring, and EE housing did not mitigate these effects. Full article

Dogs may experience negative emotional states when isolated from human caregivers and conspecifics. This study aimed to evaluate how dogs interact with different enrichments during a short period of social isolation, as a first step towards identifying methods for improving their emotional wellbeing. Using a cross-over design, dogs (n = 20) at the Waltham Petcare Science Institute were exposed to four different food-based enrichments while left alone in a familiar room for 20 min: long-lasting chew (Chew), kibble in a treat-dispensing toy (Toy), and kibble dispensed through a smart treat-dispensing device with (Device + Voice) and without (Device) a person talking to the dog. Time spent engaging with each enrichment item and emotional valence and arousal (7-point scale collected every 5-min) were scored from videos. The results of linear mixed models indicated Chew was the most successful enrichment, with dogs having lower arousal scores (p < 0.05 vs. Device and Toy) during the first five minutes of isolation, higher positive valence scores (p < 0.05 vs. all) during the second five minutes of isolation, and spending the most total time engaged (p < 0.01 vs. all). Based on these findings, long-lasting chews should be further explored to assess their impact on dog emotional wellbeing. Full article

In cases where social animals must be temporarily housed alone, environmental enrichment is particularly important. Providing animals with manipulable objects (“toys”) is a common form of environmental enrichment, but its effectiveness can be limited by animal disinterest or habituation. The current study examined whether caregiver interaction could increase the effectiveness of object-based enrichment for a quarantined bottlenose dolphin (Tursiops truncatus). Behavioral observations were conducted after a training session, after a trainer toy play session, and between interactive sessions. The results showed that the dolphin floated in place less and played with toys more after interacting with a caregiver than he did at times further removed from caregiver interaction. He was also more likely to play with the same toys that the trainer had played with, showing effects of stimulus enhancement and/or social referencing. Although this study is, of necessity, based on a single animal of a single species, these findings suggest that interacting with a caregiver can enhance the efficacy of object-based environmental enrichment for isolated animals. Full article